Cortisol response to two different doses of intravenous synthetic ACTH (tetracosactrin) in overweight cats.

Schoeman JP, Evans HJ, Childs D, Herrtage ME

The Journal of small animal practice1 Dec 2000Cited by 15 (Europe PMC)

PMID11138854DOI10.1111/j.1748-5827.2000.tb03152.xPepBankPUB-11138854

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cosyntropin.

01AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement
In overweight cats, mean cortisol was highest 60 minutes after 125 microg tetracosactrin.
In plain wordsIn cats, mean cortisol was highest 60 minutes after 125 microg tetracosactrin.
Peptide
Cosyntropin
Outcome
Not applicableTime to highest mean cortisol after 125 microg
Study
catn = 15
Overweight middle-aged to older cats
Outcome group
Adrenal Function · Endocrine and hormones
Source sentences
Summary
The highest mean serum cortisol concentration occurred at 60 minutes following the 125 microg dose and at 120 minutes following the 250 microg dose.
2 context sentences(design, population, supporting numbers)
Summary · context
Fifteen middle-aged to older, overweight cats attending a first-opinion clinic were investigated to rule out hyperadrenocorticism as a cause of their weight problem, using two different protocols for the adrenocorticotropic hormone (ACTH) stimulation test.
Summary · context
The cats received intravenous synthetic ACTH (tetracosactrin) at an initial dose of 125 microg; a second test was performed between two and three weeks later, using a dose of 250 microg intravenously.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1113885401
02AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement
In overweight cats, mean cortisol was highest 120 minutes after 250 microg tetracosactrin.
In plain wordsIn cats, mean cortisol was highest 120 minutes after 250 microg tetracosactrin.
Peptide
Cosyntropin
Outcome
Not applicableTime to highest mean cortisol after 250 microg
Study
catn = 15
Overweight middle-aged to older cats
Outcome group
Adrenal Function · Endocrine and hormones
Source sentences
Summary
The highest mean serum cortisol concentration occurred at 60 minutes following the 125 microg dose and at 120 minutes following the 250 microg dose.
2 context sentences(design, population, supporting numbers)
Summary · context
Fifteen middle-aged to older, overweight cats attending a first-opinion clinic were investigated to rule out hyperadrenocorticism as a cause of their weight problem, using two different protocols for the adrenocorticotropic hormone (ACTH) stimulation test.
Summary · context
The cats received intravenous synthetic ACTH (tetracosactrin) at an initial dose of 125 microg; a second test was performed between two and three weeks later, using a dose of 250 microg intravenously.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1113885402
03AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement
In overweight cats, peak cortisol did not differ significantly between the two tetracosactrin doses.
In plain wordsIn cats, peak cortisol did not differ significantly between the two tetracosactrin doses.
Peptide
Cosyntropin
Outcome
No significant changePeak cortisol comparison
Study
catn = 15
Overweight middle-aged to older cats
Comparator
125 microg tetracosactrin
Outcome group
Adrenal Function · Endocrine and hormones
Source sentences
Summary
There was, however, no statistically significant difference between these peak cortisol concentrations attained using either dose of tetracosactrin.
2 context sentences(design, population, supporting numbers)
Summary · context
Fifteen middle-aged to older, overweight cats attending a first-opinion clinic were investigated to rule out hyperadrenocorticism as a cause of their weight problem, using two different protocols for the adrenocorticotropic hormone (ACTH) stimulation test.
Summary · context
The cats received intravenous synthetic ACTH (tetracosactrin) at an initial dose of 125 microg; a second test was performed between two and three weeks later, using a dose of 250 microg intravenously.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1113885403
04AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement
In overweight cats, 250 microg tetracosactrin produced significantly higher mean cortisol at 180 minutes than 125 microg.
In plain wordsIn cats, 250 microg tetracosactrin produced higher cortisol at 180 minutes than 125 microg.
Peptide
Cosyntropin
Outcome
IncreaseCortisol at 180 minutes
Study
catn = 15
Overweight middle-aged to older cats
Comparator
125 microg tetracosactrin
Outcome group
Adrenal Function · Endocrine and hormones
Source sentences
Summary
A significantly higher mean serum cortisol concentration was attained after the higher dose at the 180 minutes time point, indicating a more prolonged response when compared with the lower dose.
2 context sentences(design, population, supporting numbers)
Summary · context
Fifteen middle-aged to older, overweight cats attending a first-opinion clinic were investigated to rule out hyperadrenocorticism as a cause of their weight problem, using two different protocols for the adrenocorticotropic hormone (ACTH) stimulation test.
Summary · context
The cats received intravenous synthetic ACTH (tetracosactrin) at an initial dose of 125 microg; a second test was performed between two and three weeks later, using a dose of 250 microg intravenously.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1113885404
05AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Other
In overweight cats tested with tetracosactrin, none developed hyperadrenocorticism during one year of follow-up.
In plain wordsIn cats tested with tetracosactrin, none developed hyperadrenocorticism during one year of follow-up.
Peptide
Cosyntropin
Outcome
Not applicableHyperadrenocorticism during follow-up
Study
catn = 15
Overweight middle-aged to older cats
Outcome group
Adrenal Function · Endocrine and hormones
Source sentences
Summary
The cats were followed up for one year after the initial investigations and none were found to develop hyperadrenocorticism during this time.
2 context sentences(design, population, supporting numbers)
Summary · context
Fifteen middle-aged to older, overweight cats attending a first-opinion clinic were investigated to rule out hyperadrenocorticism as a cause of their weight problem, using two different protocols for the adrenocorticotropic hormone (ACTH) stimulation test.
Summary · context
The cats received intravenous synthetic ACTH (tetracosactrin) at an initial dose of 125 microg; a second test was performed between two and three weeks later, using a dose of 250 microg intravenously.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1113885405

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

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