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Study · In vitro (cells) · mouse · 2000

5 results

Thymosin alpha1 is a time and dose-dependent antagonist of dexamethasone-induced apoptosis of murine thymocytes in vitro.

Baumann CA, Badamchian M, Goldstein AL

International journal of immunopharmacology1 Dec 2000Cited by 22 (Europe PMC)

PMID11137612 (opens in a new tab)DOI10.1016/s0192-0561(00)00065-5 (opens in a new tab)PepBankPUB-11137612
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In murine thymocytes in vitro, thymosin alpha‑1 antagonized dexamethasone-induced apoptosis at 2 to 100 microg per 10(6) thymocytes.

    In plain wordsIn lab tests on mouse thymus cells, thymosin alpha‑1 reduced steroid-induced cell death across a range of doses.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseDexamethasone-induced thymocyte apoptosis by concentration
    Study

    mousen: not reported in source

    murine thymocytes treated with dexamethasone
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    2 to 100 microg/10(6) thymocytesAs given in this study (mouse).

    Source sentences

    Summary
    Talpha1 is effective at concentrations ranging from 2 to 100 microg/10(6) thymocytes.
    1 context sentence
    Summary · context
    In the present study, we further characterize the dose and time dependence of Talpha1's antagonism of dexamethasone-induced thymocyte apoptosis.
  2. 02LabIn vitro (cells)Mechanism

    In murine thymocytes in vitro, pre-treatment with thymosin alpha‑1 was necessary for its anti-apoptotic activity.

    In plain wordsIn lab tests on mouse thymus cells, thymosin alpha‑1 only protected against cell death when given before the steroid.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableNeed for pre-treatment
    Study

    mousen: not reported in source

    murine thymocytes treated with dexamethasone
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Talpha1 pre-treatment is necessary to achieve its anti-apoptotic activity.
    1 context sentence
    Summary · context
    In the present study, we further characterize the dose and time dependence of Talpha1's antagonism of dexamethasone-induced thymocyte apoptosis.
  3. 03LabIn vitro (cells)Mechanism

    In murine thymocytes in vitro, thymosin alpha‑1 gave temporary protection by slowing dexamethasone's apoptotic activity up to 12 h after dexamethasone treatment.

    In plain wordsIn lab tests on mouse thymus cells, thymosin alpha‑1 gave only temporary protection from steroid-induced cell death.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseDuration of protection against dexamethasone
    Study

    mousen: not reported in source

    murine thymocytes treated with dexamethasone
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Talpha1 provides temporary protection to thymocytes by slowing dexamethasone's apoptotic activity up to 12 h post dexamethasone treatment.
    1 context sentence
    Summary · context
    In the present study, we further characterize the dose and time dependence of Talpha1's antagonism of dexamethasone-induced thymocyte apoptosis.
  4. 04LabIn vitro (cells)Mechanism

    In murine thymocytes in vitro, the activity of thymosin alpha‑1 was not sensitive to cycloheximide, suggesting independence from protein synthesis.

    In plain wordsIn lab tests on mouse thymus cells, blocking protein synthesis did not stop the protective effect of thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableSensitivity to cycloheximide
    Study

    mousen: not reported in source

    murine thymocytes treated with dexamethasone
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, Talpha1's activity is not sensitive to cycloheximide treatment, suggesting Talpha1's activity is independent of protein synthesis.
    1 context sentence
    Summary · context
    In the present study, we further characterize the dose and time dependence of Talpha1's antagonism of dexamethasone-induced thymocyte apoptosis.
  5. 05LabIn vitro (cells)Mechanism

    In murine thymocytes in vitro, thymosin alpha‑1 was unable to antagonize apoptosis induced by H2O2.

    In plain wordsIn lab tests on mouse thymus cells, thymosin alpha‑1 did not protect against cell death caused by hydrogen peroxide.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeHydrogen peroxide-induced apoptosis
    Study

    mousen: not reported in source

    murine thymocytes treated with dexamethasone
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, Talpha1 is unable to antagonize apoptosis induced by the reactive oxygen species, H2O2, suggesting Talpha1's antagonism of dexamethasone occurs at the early stages of dexamethasone-induced apoptosis, prior to the production of reactive oxygen species.
    1 context sentence
    Summary · context
    In the present study, we further characterize the dose and time dependence of Talpha1's antagonism of dexamethasone-induced thymocyte apoptosis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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