Vasoactive intestinal peptide-stimulated adenosine 3',5'-cyclic monophosphate formation in cerebral cortex and hypothalamus of chick and rat: comparison of the chicken and mammalian peptide.

Nowak JZ, Kuba K

Neuroscience letters1 Jan 2001Cited by 13 (Europe PMC)

PMID11121878DOI10.1016/s0304-3940(00)01676-1PepBankPUB-11121878

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
In chick and rat hypothalamus and cerebral cortex, chicken VIP was significantly more potent than mammalian VIP in evoking a cyclic AMP response.
In plain wordsIn lab tests on chick and rat brain tissue, chicken VIP raised the cell signal cAMP more strongly than mammalian VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasecAMP formation with chicken VIP versus mammalian VIP
Study
chick, ratn: not reported in source
Hypothalamus and cerebral cortex of chick and rat
Comparator
Mammalian (human/porcine/rat) VIP
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
0.01-3 microMAs given in this study (chick, rat).
Source sentences
Summary
In four tested biological systems, the chicken VIP appeared to be significantly more potent in evoking cyclic AMP response than its mammalian counterpart, the differences were more pronounced in the chick tissues, particularly in the hypothalamus, where the mammalian peptide produced only weak (but…
1 context sentence(design, population, supporting numbers)
Summary · context
Chicken and mammalian (human/porcine/rat) vasoactive intestinal peptides (VIP; 0.01-3 microM), whose structures differ by four amino acid residues in 11, 13, 26 and 28 positions, were compared with respect to their ability to stimulate adenosine 3',5'-cyclic monophosphate (cyclic AMP) formation in t…
Report a problemFND-1112187801
02LabEx vivo tissueActivity measurement
In chick hypothalamus, mammalian VIP produced only a weak but significant cyclic AMP response at the highest dose of 3 µM.
In plain wordsIn lab tests on chick brain tissue, mammalian VIP raised the cell signal cAMP only weakly, at the highest dose.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasecAMP formation with mammalian VIP in chick hypothalamus
Study
chick, ratn: not reported in source
Hypothalamus and cerebral cortex of chick and rat
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
3 microMAs given in this study (chick, rat).
Source sentences
Summary
where the mammalian peptide produced only weak (but significant) effect at the highest used dose, i.e. 3 microM
1 context sentence(design, population, supporting numbers)
Summary · context
Chicken and mammalian (human/porcine/rat) vasoactive intestinal peptides (VIP; 0.01-3 microM), whose structures differ by four amino acid residues in 11, 13, 26 and 28 positions, were compared with respect to their ability to stimulate adenosine 3',5'-cyclic monophosphate (cyclic AMP) formation in t…
Report a problemFND-1112187802

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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