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Study · Animal study (in vivo) · tilapia (oreochromis mossambicus) · 2000

2 results

The hexapeptide KP-102 (D-ala-D-beta-Nal-ala-trp-D-phe-lys-NH(2)) stimulates growth hormone release in a cichlid fish (Ooreochromis mossambicus).

Shepherd BS, Eckert SM, Parhar IS, Vijayan MM, Wakabayashi I, Hirano T, Grau EG, Chen TT

The Journal of endocrinology1 Dec 2000Cited by 21 (Europe PMC)

PMID11115782 (opens in a new tab)DOI10.1677/joe.0.167r007 (opens in a new tab)PepBankPUB-11115782
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In tilapia, KP-102 (GHRP‑2) at the low dose significantly raised plasma GH at 6 and 12 hours after injection.

    In plain wordsIn tilapia, a low dose of KP-102 raised growth hormone in the blood at 6 and 12 hours.

    Peptide
    GHRP-2
    Outcome
    IncreasePlasma GH after low-dose KP-102
    Study

    tilapia (Oreochromis mossambicus)n: not reported in source

    in vivo
    Comparator
    Vehicle
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 ng/g body weight · intraperitoneal injectionAs given in this study (tilapia (Oreochromis mossambicus)).

    Source sentences

    Summary
    KP-102 also significantly elevated GH levels (at the low dose) at 6 (P<0.05) and 12 (P<0.01) hours post-injection.
    1 context sentence
    Summary · context
    Tilapia (Oreochromis mossambicus) were given a single intraperitoneal injection of KP-102 (D-Ala-D-beta;-Nal-Ala-Trp-D-Phe-Lys-NH(2)) or bovine GHRH(1-29)-amide or vehicle and blood was sampled at 1, 6 and 12 h after injection.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In tilapia, KP-102 had no significant effect on plasma prolactin levels, although mean levels were elevated at 6 hours.

    In plain wordsIn tilapia, KP-102 did not significantly change prolactin levels.

    Peptide
    GHRP-2
    Outcome
    No significant changePlasma prolactin levels
    Study

    tilapia (Oreochromis mossambicus)n: not reported in source

    in vivo
    Comparator
    Vehicle
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 ng/g and 10 ng/g body weight · intraperitoneal injectionAs given in this study (tilapia (Oreochromis mossambicus)).

    Source sentences

    Summary
    There were no significant effects on plasma PRL(s) levels, although mean levels of both PRLs were elevated at 6 h post-injection.
    1 context sentence
    Summary · context
    Tilapia (Oreochromis mossambicus) were given a single intraperitoneal injection of KP-102 (D-Ala-D-beta;-Nal-Ala-Trp-D-Phe-Lys-NH(2)) or bovine GHRH(1-29)-amide or vehicle and blood was sampled at 1, 6 and 12 h after injection.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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