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Study · Animal study (in vivo) · rat · 2000

4 results

Divergence of mucosal and motor effects of insulin-like growth factor (IGF)-I and LR3IGF-I on rat isolated ileum following abdominal irradiation.

Fraser R, Frisby C, Schirmer M, Blackshaw LA, Langman J, Howarth G, Yeoh EK

Journal of gastroenterology and hepatology1 Oct 2000Cited by 5 (Europe PMC)

PMID11106092 (opens in a new tab)DOI10.1046/j.1440-1746.2000.02329.x (opens in a new tab)PepBankPUB-11106092
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated rats, LR3IGF-I did not change the frequency of high-amplitude long-duration ileal pressure waves versus vehicle.

    In plain wordsIn irradiated rats, an IGF-I analogue did not change how often abnormal gut pressure waves occurred, compared with vehicle.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeFrequency of high-amplitude long-duration pressure waves
    Study

    ratn = 7

    Explanted rat ileum after 10 Gy abdominal irradiation
    Comparator
    Vehicle
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    5 mg/kg per day · osmotic mini-pumpAs given in this study (rat).

    Source sentences

    Summary
    Insulin-like growth factor-I and LR3IGF-I had no effect on the frequency, amplitude or migration characteristics of HALD pressure waves compared with vehicle.
    2 context sentences
    Summary · context
    The aim of the present study was to evaluate the effects of IGF-I (5 mg/kg per day) and the more potent analog LR3IGF-I (5 mg/kg per day) on neurally mediated ileal dysmotility following irradiation.
    Summary · context
    At the time of irradiation, all rats underwent implantation of an osmotic mini-pump that contained 100 mmol/L acetic acid vehicle (n = 8), IGF-I (n = 8) or LR3IGF-I (n = 7).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated rats, LR3IGF-I did not change the amplitude of high-amplitude long-duration ileal pressure waves versus vehicle.

    In plain wordsIn irradiated rats, an IGF-I analogue did not change the strength of abnormal gut pressure waves, compared with vehicle.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeAmplitude of high-amplitude long-duration pressure waves
    Study

    ratn = 7

    Explanted rat ileum after 10 Gy abdominal irradiation
    Comparator
    Vehicle
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    5 mg/kg per day · osmotic mini-pumpAs given in this study (rat).

    Source sentences

    Summary
    Insulin-like growth factor-I and LR3IGF-I had no effect on the frequency, amplitude or migration characteristics of HALD pressure waves compared with vehicle.
    2 context sentences
    Summary · context
    The aim of the present study was to evaluate the effects of IGF-I (5 mg/kg per day) and the more potent analog LR3IGF-I (5 mg/kg per day) on neurally mediated ileal dysmotility following irradiation.
    Summary · context
    At the time of irradiation, all rats underwent implantation of an osmotic mini-pump that contained 100 mmol/L acetic acid vehicle (n = 8), IGF-I (n = 8) or LR3IGF-I (n = 7).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated rats, LR3IGF-I did not change the migration characteristics of high-amplitude long-duration ileal pressure waves versus vehicle.

    In plain wordsIn irradiated rats, an IGF-I analogue did not change how abnormal gut pressure waves moved, compared with vehicle.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeMigration of high-amplitude long-duration pressure waves
    Study

    ratn = 7

    Explanted rat ileum after 10 Gy abdominal irradiation
    Comparator
    Vehicle
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    5 mg/kg per day · osmotic mini-pumpAs given in this study (rat).

    Source sentences

    Summary
    Insulin-like growth factor-I and LR3IGF-I had no effect on the frequency, amplitude or migration characteristics of HALD pressure waves compared with vehicle.
    2 context sentences
    Summary · context
    The aim of the present study was to evaluate the effects of IGF-I (5 mg/kg per day) and the more potent analog LR3IGF-I (5 mg/kg per day) on neurally mediated ileal dysmotility following irradiation.
    Summary · context
    At the time of irradiation, all rats underwent implantation of an osmotic mini-pump that contained 100 mmol/L acetic acid vehicle (n = 8), IGF-I (n = 8) or LR3IGF-I (n = 7).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated rats, LR3IGF-I reduced histologic mucosal damage of the ileum versus vehicle.

    In plain wordsIn irradiated rats, an IGF-I analogue reduced gut lining damage compared with vehicle.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseHistologic mucosal damage
    Study

    ratn = 7

    Explanted rat ileum after 10 Gy abdominal irradiation
    Comparator
    Vehicle
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    5 mg/kg per day · osmotic mini-pumpAs given in this study (rat).

    Source sentences

    Summary
    Histologic damage was reduced in animals that received IGF-I and LR3IGF-I compared with vehicle-treated animals.
    3 context sentences
    Summary · context
    In radiotherapy treated animals, the degree of mucosal damage was determined using a standardized histologic scoring system.
    Summary · context
    The aim of the present study was to evaluate the effects of IGF-I (5 mg/kg per day) and the more potent analog LR3IGF-I (5 mg/kg per day) on neurally mediated ileal dysmotility following irradiation.
    Summary · context
    At the time of irradiation, all rats underwent implantation of an osmotic mini-pump that contained 100 mmol/L acetic acid vehicle (n = 8), IGF-I (n = 8) or LR3IGF-I (n = 7).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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