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Study · In vitro (cells) · rat · 2000

4 results

A novel peptide prevents death in enriched neuronal cultures.

Zemlyak I, Furman S, Brenneman DE, Gozes I

Regulatory peptides1 Dec 2000Cited by 58 (Europe PMC)

PMID11102650 (opens in a new tab)DOI10.1016/s0167-0115(00)00198-1 (opens in a new tab)PepBankPUB-11102650
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In newborn rat cortical cultures, NAP prevented the neuronal survival reduction induced by beta-amyloid.

    In plain wordsIn cells from newborn rats, NAP prevented the loss of neurons caused by beta-amyloid.

    Peptide
    Davunetide
    Outcome
    IncreaseSurvival after beta-amyloid exposure
    Study

    ratn: not reported in source

    Cerebral cortical cultures derived from newborn rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10(-13)-10(-11) M · 24 hAs given in this study (rat).

    Source sentences

    Summary
    In these cultures, a 24-h treatment with the beta-amyloid peptide (the Alzheimer's disease associated toxin) induced a 30-40% reduction in neuronal survival that was prevented by NAP (10(-13)-10(-11) M).
    1 context sentence
    Summary · context
    The number of surviving neurons was assessed in cerebral cortical cultures derived from newborn rats.
  2. 02LabIn vitro (cells)Efficacy outcome

    In newborn rat cortical cultures, NAP achieved maximal neuronal survival at 10(-12) M.

    In plain wordsIn cells from newborn rats, NAP produced the greatest neuron survival at 10(-12) M.

    Peptide
    Davunetide
    Outcome
    Not applicableConcentration for maximal neuronal survival
    Study

    ratn: not reported in source

    Cerebral cortical cultures derived from newborn rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10(-12) MAs given in this study (rat).

    Source sentences

    Summary
    Maximal survival was achieved at NAP concentrations of 10(-12) M.
    1 context sentence
    Summary · context
    The number of surviving neurons was assessed in cerebral cortical cultures derived from newborn rats.
  3. 03LabIn vitro (cells)Efficacy outcome

    In newborn rat cortical cultures, a single initial NAP addition produced maximal protection at 10(-10) M during a 5-day incubation.

    In plain wordsIn cells from newborn rats, one initial NAP treatment gave maximal protection at 10(-10) M during a 5-day incubation.

    Peptide
    Davunetide
    Outcome
    IncreaseProtection during prolonged incubation
    Study

    ratn: not reported in source

    Cerebral cortical cultures derived from newborn rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10(-10) M · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    In a second set of experiments, a 5-day incubation period, with NAP added once (at the beginning of the incubation period) exhibited maximal protection at 10(-10) M NAP.
    1 context sentence
    Summary · context
    The number of surviving neurons was assessed in cerebral cortical cultures derived from newborn rats.
  4. 04LabIn vitro (cells)Efficacy outcome

    In newborn rat cortical cultures, NAP prevented neuronal death after glucose deprivation.

    In plain wordsIn cells from newborn rats, NAP prevented neuron death after glucose deprivation.

    Peptide
    Davunetide
    Outcome
    DecreaseNeuronal death after glucose deprivation
    Study

    ratn: not reported in source

    Cerebral cortical cultures derived from newborn rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 24 hAs given in this study (rat).

    Source sentences

    Summary
    In a third set of experiments, a 10-min period of glucose deprivation resulted in a 30-40% neuronal death that was prevented by a 24-h incubation with NAP.
    1 context sentence
    Summary · context
    The number of surviving neurons was assessed in cerebral cortical cultures derived from newborn rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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