Skip to content

Study · Animal study (in vivo) · chicken · 2000

8 results

The effect of thymulin on avian IL-2 receptor expression.

Chandratilleke D, Marsh JA

International journal of immunopharmacology1 Nov 2000Cited by 10 (Europe PMC)

PMID11090697 (opens in a new tab)DOI10.1016/s0192-0561(00)00051-5 (opens in a new tab)PepBankPUB-11090697
Publisher pagePubMedAsk about this study
Jump to 8 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In SLD chickens, thymulin increased the number of IL-2R-positive splenocytes.

    In plain wordsIn SLD chickens, thymulin increased the number of spleen cells with IL-2 receptors.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseIL-2R-positive cells in SLD
    Study

    chickenn: not reported in source

    K and SLD chickens
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.05 and 5.0 ng/100 g body weight daily · from hatching until 4 weeks of ageAs given in this study (chicken).

    Source sentences

    Summary
    Thymulin treatment increased the number of IL-2R+ cells in the SLD but had the opposite effect in K strain chickens.
    1 context sentence
    Summary · context
    Daily thymulin injections of 0, 0.05 and 5.0 ng/100 g body weight were given from hatching until 4 weeks of age.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In K strain chickens, thymulin decreased the number of IL-2R-positive splenocytes.

    In plain wordsIn K strain chickens, thymulin decreased the number of spleen cells with IL-2 receptors.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseIL-2R-positive cells in K strain
    Study

    chickenn: not reported in source

    K and SLD chickens
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.05 and 5.0 ng/100 g body weight daily · from hatching until 4 weeks of ageAs given in this study (chicken).

    Source sentences

    Summary
    Thymulin treatment increased the number of IL-2R+ cells in the SLD but had the opposite effect in K strain chickens.
    1 context sentence
    Summary · context
    Daily thymulin injections of 0, 0.05 and 5.0 ng/100 g body weight were given from hatching until 4 weeks of age.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In chickens, thymulin had little effect on IL-2R density within small splenocyte populations.

    In plain wordsIn chickens, thymulin had little effect on IL-2 receptor density in small spleen cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Direction not reportedIL-2R density in small cells
    Study

    chickenn: not reported in source

    K and SLD chickens
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.05 and 5.0 ng/100 g body weight daily · from hatching until 4 weeks of ageAs given in this study (chicken).

    Source sentences

    Summary
    Mitogen activation or thymulin treatment had little effect on the IL-2R density within small cell populations.
    1 context sentence
    Summary · context
    Daily thymulin injections of 0, 0.05 and 5.0 ng/100 g body weight were given from hatching until 4 weeks of age.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In SLD chickens, thymulin decreased IL-2R density on large unstimulated splenocytes.

    In plain wordsIn SLD chickens, thymulin decreased IL-2 receptor density on large unstimulated spleen cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseIL-2R density in large unstimulated SLD cells
    Study

    chickenn: not reported in source

    K and SLD chickens
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.05 and 5.0 ng/100 g body weight daily · from hatching until 4 weeks of ageAs given in this study (chicken).

    Source sentences

    Summary
    IL-2R densities on non-stimulated larger cells decreased in the SLD after thymulin exposure.
    1 context sentence
    Summary · context
    Daily thymulin injections of 0, 0.05 and 5.0 ng/100 g body weight were given from hatching until 4 weeks of age.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In chickens, thymulin did not affect mean IL-2R density on large activated splenocytes.

    In plain wordsIn chickens, thymulin did not affect IL-2 receptor density on large activated spleen cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeIL-2R density in large activated cells
    Study

    chickenn: not reported in source

    K and SLD chickens
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.05 and 5.0 ng/100 g body weight daily · from hatching until 4 weeks of ageAs given in this study (chicken).

    Source sentences

    Summary
    Thymulin treatment produced no effect on the mean IL-2R densities for large activated cells.
    1 context sentence
    Summary · context
    Daily thymulin injections of 0, 0.05 and 5.0 ng/100 g body weight were given from hatching until 4 weeks of age.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In chickens, thymulin modulated CD4 expression density without a stated direction.

    In plain wordsIn chickens, thymulin changed CD4 expression density, but the abstract does not state the direction.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Direction not reportedCD4 expression density
    Study

    chickenn: not reported in source

    K and SLD chickens
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.05 and 5.0 ng/100 g body weight daily · from hatching until 4 weeks of ageAs given in this study (chicken).

    Source sentences

    Summary
    The density of CD4 expression was modulated by both mitogen activation and thymulin treatment.
    1 context sentence
    Summary · context
    Daily thymulin injections of 0, 0.05 and 5.0 ng/100 g body weight were given from hatching until 4 weeks of age.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In K and SLD chickens, thymulin had little effect on the CD8-positive splenocyte population.

    In plain wordsIn chickens, thymulin had little effect on the number of CD8-positive spleen cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Direction not reportedCD8-positive cell numbers
    Study

    chickenn: not reported in source

    K and SLD chickens
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.05 and 5.0 ng/100 g body weight daily · from hatching until 4 weeks of ageAs given in this study (chicken).

    Source sentences

    Summary
    The SLD had fewer CD8+ cells than did the K strain and thymulin treatment had little effect on this population in either strain.
    1 context sentence
    Summary · context
    Daily thymulin injections of 0, 0.05 and 5.0 ng/100 g body weight were given from hatching until 4 weeks of age.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In chickens, thymulin had little effect on CD8 density on CD8-positive splenocytes.

    In plain wordsIn chickens, thymulin had little effect on CD8 density on CD8-positive spleen cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Direction not reportedCD8 density
    Study

    chickenn: not reported in source

    K and SLD chickens
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.05 and 5.0 ng/100 g body weight daily · from hatching until 4 weeks of ageAs given in this study (chicken).

    Source sentences

    Summary
    Mitogen stimulation increased the density of CD8 on CD8+ cells but again thymulin treatment had little effect.
    1 context sentence
    Summary · context
    Daily thymulin injections of 0, 0.05 and 5.0 ng/100 g body weight were given from hatching until 4 weeks of age.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.