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Study · Animal study (in vivo) · rabbit · 2000

6 results

Pretreatment with growth hormone-releasing peptide-2 directly protects against the diastolic dysfunction of myocardial stunning in an isolated, blood-perfused rabbit heart model.

Weekers F, Van Herck E, Isgaard J, Van den Berghe G

Endocrinology1 Nov 2000Cited by 24 (Europe PMC)

PMID11089529 (opens in a new tab)DOI10.1210/endo.141.11.7768 (opens in a new tab)PepBankPUB-11089529
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rabbits, 14 days of GHRP‑2 raised serum IGF-I by 8 +/- 15%, far less than the 142 +/- 116% rise with rhGH.

    In plain wordsIn rabbits, GHRP‑2 raised IGF-I much less than growth hormone itself did.

    Peptide
    GHRP-2
    Outcome
    DecreaseSerum IGF-I rise after 14 days
    Study

    rabbitn = 8

    isolated blood-perfused heart
    Comparator
    rhGH 3.5 mg/kg x day
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    160 microg/kg x day in two divided doses · subcutaneous · 14 daysAs given in this study (rabbit).

    Measurements

    Serum IGF-I rise
    8%
    GHRP-2

    Source sentences

    Summary
    Pretreatment with rhGH for 14 days induced a 142 +/- 116% rise of serum IGF-I vs. 8 +/- 15% with GHRP-2 (P < 0.001) and increased body weight with 6.8 +/- 2.5% vs. 3.4 +/- 3.3% with GHRP-2 (P = 0.01).
    2 context sentences
    Summary · context
    In a second set, animals were pretreated for 14 days with SC rhGH 3.5 mg/kg x day (n = 9) or 160 microg/kg x day GHRP-2 (n = 8) in two divided doses.
    Summary · context
    Hearts were excised and submitted to 15 min ischemia followed by 80 min reperfusion, after which postischemic recovery was compared with nonischemic hearts mounted into the same system.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rabbits, GHRP‑2 pretreatment increased body weight by 3.4 +/- 3.3%, less than the 6.8 +/- 2.5% with rhGH.

    In plain wordsIn rabbits, GHRP‑2 led to less weight gain than growth hormone itself.

    Peptide
    GHRP-2
    Outcome
    DecreaseBody weight gain after 14 days
    Study

    rabbitn = 8

    isolated blood-perfused heart
    Comparator
    rhGH 3.5 mg/kg x day
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    160 microg/kg x day in two divided doses · subcutaneous · 14 daysAs given in this study (rabbit).

    Measurements

    Body weight increase
    3.4%
    GHRP-2

    Source sentences

    Summary
    Pretreatment with rhGH for 14 days induced a 142 +/- 116% rise of serum IGF-I vs. 8 +/- 15% with GHRP-2 (P < 0.001) and increased body weight with 6.8 +/- 2.5% vs. 3.4 +/- 3.3% with GHRP-2 (P = 0.01).
    2 context sentences
    Summary · context
    In a second set, animals were pretreated for 14 days with SC rhGH 3.5 mg/kg x day (n = 9) or 160 microg/kg x day GHRP-2 (n = 8) in two divided doses.
    Summary · context
    Hearts were excised and submitted to 15 min ischemia followed by 80 min reperfusion, after which postischemic recovery was compared with nonischemic hearts mounted into the same system.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rabbits, circulating rabbit GH remained identical in all animals, including those pretreated with GHRP‑2.

    In plain wordsIn rabbits, the animals' own growth hormone levels stayed the same in every group.

    Peptide
    GHRP-2
    Outcome
    No significant changeCirculating rabbit GH
    Study

    rabbitn = 8

    isolated blood-perfused heart
    Comparator
    Other groups
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    160 microg/kg x day in two divided doses · subcutaneous · 14 daysAs given in this study (rabbit).

    Source sentences

    Summary
    Circulating levels of rabbit GH (rGH) remained identical in all animals.
    2 context sentences
    Summary · context
    In a second set, animals were pretreated for 14 days with SC rhGH 3.5 mg/kg x day (n = 9) or 160 microg/kg x day GHRP-2 (n = 8) in two divided doses.
    Summary · context
    Hearts were excised and submitted to 15 min ischemia followed by 80 min reperfusion, after which postischemic recovery was compared with nonischemic hearts mounted into the same system.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In isolated rabbit hearts, GHRP‑2 pretreatment did not change postischemic recovery of left ventricular systolic function.

    In plain wordsIn isolated rabbit hearts, GHRP‑2 did not change how well the pumping function recovered after blocked blood flow.

    Peptide
    GHRP-2
    Outcome
    No significant changePostischemic recovery of left ventricular systolic function
    Study

    rabbitn = 8

    isolated blood-perfused heart
    Comparator
    Unpretreated and rhGH pretreated hearts
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    160 microg/kg x day in two divided doses · subcutaneous · 14 daysAs given in this study (rabbit).

    Source sentences

    Summary
    No difference in postischemic recovery of left ventricular systolic function among the unpretreated, rhGH pretreated and GHRP-2 pretreated hearts was apparent.
    2 context sentences
    Summary · context
    In a second set, animals were pretreated for 14 days with SC rhGH 3.5 mg/kg x day (n = 9) or 160 microg/kg x day GHRP-2 (n = 8) in two divided doses.
    Summary · context
    Hearts were excised and submitted to 15 min ischemia followed by 80 min reperfusion, after which postischemic recovery was compared with nonischemic hearts mounted into the same system.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In isolated rabbit hearts, GHRP‑2 pretreatment lowered end-diastolic pressure to half the level in unpretreated and rhGH pretreated hearts, matching non-ischemic hearts.

    In plain wordsIn isolated rabbit hearts, GHRP‑2 pretreatment kept relaxation pressure about half as high as in untreated hearts after blocked blood flow.

    Peptide
    GHRP-2
    Outcome
    DecreaseEnd-diastolic pressure after reperfusion (diastolic function)
    Study

    rabbitn = 8

    isolated blood-perfused heart
    Comparator
    Unpretreated and rhGH pretreated hearts
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    160 microg/kg x day in two divided doses · subcutaneous · 14 daysAs given in this study (rabbit).

    Source sentences

    Summary
    In the GHRP-2 pretreated hearts, EDP decreased to half the pressure observed in unpretreated and rhGH pretreated hearts (all P < or = 0.02), a level which was indistinguishable from that in the non-ischemic hearts, suggesting full postischemic recovery of diastolic function.
    2 context sentences
    Summary · context
    In a second set, animals were pretreated for 14 days with SC rhGH 3.5 mg/kg x day (n = 9) or 160 microg/kg x day GHRP-2 (n = 8) in two divided doses.
    Summary · context
    Hearts were excised and submitted to 15 min ischemia followed by 80 min reperfusion, after which postischemic recovery was compared with nonischemic hearts mounted into the same system.
  6. 06AnimalAnimal study (in vivo)Safety outcome

    In isolated rabbit hearts, there were no signs of increased apoptosis in the experimental groups, GHRP‑2 pretreatment included.

    In plain wordsIn rabbit hearts, no signs of more cell death were seen in any group.

    Peptide
    GHRP-2
    Outcome
    No significant changeMarkers of apoptosis in heart tissue
    Study

    rabbitn = 8

    isolated blood-perfused heart
    Comparator
    Other experimental groups
    Outcome group
    Cell viability and death · Cardiovascular
    Studied dose
    160 microg/kg x day in two divided doses · subcutaneous · 14 daysAs given in this study (rabbit).

    Source sentences

    Summary
    There were no signs of increased apoptosis in the experimental groups.
    2 context sentences
    Summary · context
    In a second set, animals were pretreated for 14 days with SC rhGH 3.5 mg/kg x day (n = 9) or 160 microg/kg x day GHRP-2 (n = 8) in two divided doses.
    Summary · context
    Hearts were excised and submitted to 15 min ischemia followed by 80 min reperfusion, after which postischemic recovery was compared with nonischemic hearts mounted into the same system.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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