Skip to content

Study · Animal study (in vivo) · drosophila melanogaster · 2000

4 results

Effect of epitalon on the lifespan increase in Drosophila melanogaster.

Khavinson VK, Izmaylov DM, Obukhova LK, Malinin VV

Mechanisms of ageing and development1 Dec 2000Cited by 28 (Europe PMC)

PMID11087911 (opens in a new tab)DOI10.1016/s0047-6374(00)00217-7 (opens in a new tab)PepBankPUB-11087911
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male Drosophila melanogaster, Epitalon applied at the developmental stage significantly increased imago lifespan across a range of very low concentrations.

    In plain wordsIn male fruit flies, epitalon given at the larval stage lengthened adult lifespan.

    Peptide
    Epitalon
    Outcome
    IncreaseLifespan of male imagoes
    Study

    Drosophila melanogastern: not reported in source

    Canton-S wild strain
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    0.001 x 10(-6) to 5 x 10(-6) wt.% of culture medium · added to culture medium · developmental stage only (egg to larva)As given in this study (Drosophila melanogaster).

    Measurements

    Lifespan increase
    11 to 16%
    males and females combined

    Source sentences

    Summary
    Epitalon significantly increased the lifespan (LS) of imagoes by 11-16% when applied at unprecedented low concentrations-from 0.001 x 10(-6) to 5 x 10(-6) wt.% of culture medium for males and from 0.01 x 10(-6) to 0.1 x 10(-6) wt.% of culture medium for females.
    2 context sentences
    Summary · context
    The geroprotector activity of epitalon, a synthetic tetrapeptide Ala-Glu-Asp-Gly, was studied on the Drosophila melanogaster wild strain Canton-S.
    Summary · context
    The substance was added to the culture medium only at the developmental stage (from egg to larva).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In female Drosophila melanogaster, Epitalon applied at the developmental stage significantly increased imago lifespan across a range of very low concentrations.

    In plain wordsIn female fruit flies, epitalon given at the larval stage lengthened adult lifespan.

    Peptide
    Epitalon
    Outcome
    IncreaseLifespan of female imagoes
    Study

    Drosophila melanogastern: not reported in source

    Canton-S wild strain
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    0.01 x 10(-6) to 0.1 x 10(-6) wt.% of culture medium · added to culture medium · developmental stage only (egg to larva)As given in this study (Drosophila melanogaster).

    Measurements

    Lifespan increase
    11 to 16%
    males and females combined

    Source sentences

    Summary
    Epitalon significantly increased the lifespan (LS) of imagoes by 11-16% when applied at unprecedented low concentrations-from 0.001 x 10(-6) to 5 x 10(-6) wt.% of culture medium for males and from 0.01 x 10(-6) to 0.1 x 10(-6) wt.% of culture medium for females.
    2 context sentences
    Summary · context
    The geroprotector activity of epitalon, a synthetic tetrapeptide Ala-Glu-Asp-Gly, was studied on the Drosophila melanogaster wild strain Canton-S.
    Summary · context
    The substance was added to the culture medium only at the developmental stage (from egg to larva).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In Drosophila melanogaster, the increase in lifespan with Epitalon did not depend on the dose.

    In plain wordsIn fruit flies, the lifespan gain from epitalon did not depend on the dose.

    Peptide
    Epitalon
    Outcome
    No significant changeDose dependence of lifespan increase
    Study

    Drosophila melanogastern: not reported in source

    Canton-S wild strain
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated · added to culture medium · developmental stage only (egg to larva)As given in this study (Drosophila melanogaster).

    Source sentences

    Summary
    The increase in LS did not depend on the substance dose.
    2 context sentences
    Summary · context
    The geroprotector activity of epitalon, a synthetic tetrapeptide Ala-Glu-Asp-Gly, was studied on the Drosophila melanogaster wild strain Canton-S.
    Summary · context
    The substance was added to the culture medium only at the developmental stage (from egg to larva).
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In Drosophila melanogaster, effective concentrations of Epitalon were 16,000-80,000,000 times lower than those of melatonin.

    In plain wordsIn fruit flies, epitalon worked at far lower concentrations than melatonin.

    Peptide
    Epitalon
    Outcome
    Not applicableEffective concentration compared with melatonin
    Study

    Drosophila melanogastern: not reported in source

    Canton-S wild strain
    Comparator
    Melatonin
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated · added to culture medium · developmental stage only (egg to larva)As given in this study (Drosophila melanogaster).

    Source sentences

    Summary
    Effective concentrations of epitalon were 16,000-80,000,000 times lower than those of melatonin.
    2 context sentences
    Summary · context
    The geroprotector activity of epitalon, a synthetic tetrapeptide Ala-Glu-Asp-Gly, was studied on the Drosophila melanogaster wild strain Canton-S.
    Summary · context
    The substance was added to the culture medium only at the developmental stage (from egg to larva).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.