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Study · In vitro (cells) · 2000

3 results

Alpha-melanocyte-stimulating hormone peptides inhibit HIV-1 expression in chronically infected promonocytic U1 cells and in acutely infected monocytes.

Barcellini W, Colombo G, La Maestra L, Clerici G, Garofalo L, Brini AT, Lipton JM, Catania A

Journal of leukocyte biology1 Nov 2000Cited by 12 (Europe PMC)

PMID11073109 (opens in a new tab)PepBankPUB-11073109
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In chronically HIV-1-infected U1 cells, KPV reduced HIV expression (p24 antigen release).

    In plain wordsIn cells, KPV reduced HIV production in chronically infected immune cells.

    Peptide
    KPV
    Outcome
    DecreaseHIV p24 antigen release by TNF-alpha-stimulated U1 cells
    Study

    humann: not reported in source

    chronically HIV-1-infected U1 promonocytic cells
    Outcome group
    Antiviral activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    To determine effects of pharmacological concentrations of alpha-MSH peptides on HIV expression, we measured p24 antigen release by TNF-alpha-stimulated U1 cells exposed to a wide range of concentrations of synthetic alpha-MSH and KPV. Viral expression was reduced by both peptides.
  2. 02LabIn vitro (cells)Activity measurement

    In acutely HIV-infected monocyte-derived macrophages, KPV effectively reduced HIV replication.

    In plain wordsIn cells, KPV reduced HIV replication in newly infected immune cells.

    Peptide
    KPV
    Outcome
    DecreaseHIV replication in acutely infected monocyte-derived macrophages
    Study

    humann: not reported in source

    acutely infected monocyte-derived macrophages
    Outcome group
    Antiviral activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KPV also effectively reduced HIV replication in acutely infected monocyte-derived macrophages (MDM).
  3. 03LabIn vitro (cells)Mechanism

    In HIV-infected cells, KPV inhibited activation of NF-kappaB, which enhances viral expression.

    In plain wordsIn cells, KPV blocked NF-kappaB activation, a signal that helps HIV spread.

    Peptide
    KPV
    Outcome
    DecreaseNF-kappaB activation
    Study

    humann: not reported in source

    HIV-1-infected cells
    Outcome group
    Receptor activity and mechanism · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The basis of the peptide influence on viral replication is at the transcriptional level; KPV inhibited activation of NF-kappaB that is known to enhance viral expression.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

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