Skip to content

Study · Animal study (in vivo) · rat · 2000

4 results

Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats.

Hewson AK, Dickson SL

Journal of neuroendocrinology1 Nov 2000Cited by 242 (Europe PMC)

PMID11069119 (opens in a new tab)DOI10.1046/j.1365-2826.2000.00584.x (opens in a new tab)PepBankPUB-11069119
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In normally fed rats, GHRP‑6 significantly increased arcuate cells expressing Fos.

    In plain wordsIn normally fed rats, GHRP‑6 increased the number of arcuate cells expressing Fos.

    Peptide
    GHRP-6
    Outcome
    IncreaseArcuate Fos-positive cells
    Study

    ratn: not reported in source

    fed and fasted rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In normally fed rats, both ghrelin and GHRP-6 (a synthetic GHS) significantly increased the number of cells expressing Fos and Egr-1 in the arcuate nucleus.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In normally fed rats, GHRP‑6 significantly increased arcuate cells expressing Egr-1.

    In plain wordsIn normally fed rats, GHRP‑6 increased the number of arcuate cells expressing Egr-1.

    Peptide
    GHRP-6
    Outcome
    IncreaseArcuate Egr-1-positive cells
    Study

    ratn: not reported in source

    fed and fasted rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In normally fed rats, both ghrelin and GHRP-6 (a synthetic GHS) significantly increased the number of cells expressing Fos and Egr-1 in the arcuate nucleus.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, GHRP‑6 induced greater Fos expression during fasting than during feeding.

    In plain wordsIn rats, GHRP‑6 induced more Fos expression in fasted rats than in fed rats.

    Peptide
    GHRP-6
    Outcome
    IncreaseFasting enhancement of Fos induction
    Study

    ratn: not reported in source

    fed and fasted rats
    Comparator
    Fed rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The effects of ghrelin and GHRP-6 to induce Fos or Egr-1 protein expression was significantly greater in fasted than in fed rats.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, GHRP‑6 induced greater Egr-1 expression during fasting than during feeding.

    In plain wordsIn rats, GHRP‑6 induced more Egr-1 expression in fasted rats than in fed rats.

    Peptide
    GHRP-6
    Outcome
    IncreaseFasting enhancement of Egr-1 induction
    Study

    ratn: not reported in source

    fed and fasted rats
    Comparator
    Fed rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The effects of ghrelin and GHRP-6 to induce Fos or Egr-1 protein expression was significantly greater in fasted than in fed rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.