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Study · Non-randomized trial · n = 7 · 2000

5 results

Effect of systemic oxytocin administration on dexamethasone-induced leptin secretion in normal and obese men.

Chiodera P, Volpi R, Capretti L, Cataldo S, Speroni G, Coiro V

The Journal of clinical endocrinology and metabolism1 Oct 2000Cited by 7 (Europe PMC)

PMID11061523 (opens in a new tab)DOI10.1210/jcem.85.10.6890 (opens in a new tab)PepBankPUB-11061523
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy non-obese men given dexamethasone, oxytocin at 1 mIU/min did not modify the rise in serum leptin.

    In plain wordsIn healthy men given dexamethasone, a low dose of oxytocin did not change the leptin rise.

    Peptide
    Oxytocin
    Outcome
    No significant changeDexamethasone-induced leptin rise with 1 mIU/min OT, normal-weight men
    Study

    n = 7

    Comparator
    Dexamethasone with saline
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    1 mIU/min · intravenous · 10 hAs given in this study (human).

    Source sentences

    Summary
    The leptin response to dex was not modified by the concomitant infusion of 1 mIU/min OT
    1 context sentence
    Summary · context
    To establish whether the regulatory mechanism of leptin secretion is sensitive to oxytocin (OT), seven healthy nonobese men were tested with dexamethasone (dex; 4 mg, iv, at 0730 h) in feeding (2000 Cal given at 3 meals over 7 h) conditions either in the absence (iv normal saline infusion) or in the…
  2. 02HumanNon-randomized trialEfficacy outcome

    In healthy non-obese men given dexamethasone, oxytocin at 2 or 4 mIU/min completely abolished the rise in serum leptin.

    In plain wordsIn healthy men given dexamethasone, higher doses of oxytocin stopped the leptin rise.

    Peptide
    Oxytocin
    Outcome
    DecreaseDexamethasone-induced leptin rise with 2 or 4 mIU/min OT, normal-weight men
    Study

    n = 7

    Comparator
    Dexamethasone with saline
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    2 or 4 mIU/min · intravenous · 10 hAs given in this study (human).

    Source sentences

    Summary
    whereas it was completely abolished by the administration of 2 or 4 mIU/min OT.
    1 context sentence
    Summary · context
    To establish whether the regulatory mechanism of leptin secretion is sensitive to oxytocin (OT), seven healthy nonobese men were tested with dexamethasone (dex; 4 mg, iv, at 0730 h) in feeding (2000 Cal given at 3 meals over 7 h) conditions either in the absence (iv normal saline infusion) or in the…
  3. 03HumanNon-randomized trialEfficacy outcome

    In healthy non-obese men, intravenous oxytocin alone at 1, 2 or 4 mIU/min did not change serum leptin; levels stayed constant as with saline.

    In plain wordsIn healthy men, oxytocin alone did not change blood leptin levels compared with saline.

    Peptide
    Oxytocin
    Outcome
    No significant changeSerum leptin during OT infusion alone, normal-weight men
    Study

    n = 6

    Comparator
    Normal saline
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    1, 2 or 4 mIU/min · intravenous · 10 hAs given in this study (human).

    Source sentences

    Summary
    Leptin levels remained constant during the infusion of normal saline or OT (1, 2, or 4 mIU/min) alone.
    2 context sentences
    Summary · context
    In six additional subjects under similar experimental conditions, normal saline or OT (1, 2, or 4 mIU/min from 0730 h for 10 h) were infused iv without the previous treatment with dexamethasone.
    Summary · context
    To establish whether the regulatory mechanism of leptin secretion is sensitive to oxytocin (OT), seven healthy nonobese men were tested with dexamethasone (dex; 4 mg, iv, at 0730 h) in feeding (2000 Cal given at 3 meals over 7 h) conditions either in the absence (iv normal saline infusion) or in the…
  4. 04HumanNon-randomized trialEfficacy outcome

    In obese subjects, intravenous oxytocin alone at 1, 2 or 4 mIU/min did not change serum leptin.

    In plain wordsIn obese people, oxytocin alone did not change blood leptin levels.

    Peptide
    Oxytocin
    Outcome
    No significant changeSerum leptin during OT infusion alone, obese subjects
    Study

    n = 6

    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    1, 2 or 4 mIU/min · intravenous · 10 hAs given in this study (human).

    Source sentences

    Summary
    In 6 obese subjects, the infusion of OT alone (1, 2, or 4 mIU/min) was unable to change serum leptin levels.
    1 context sentence
    Summary · context
    These findings led us to evaluate the secretory pattern of leptin in 12 obese patients in similar experimental conditions.
  5. 05HumanNon-randomized trialEfficacy outcome

    In obese subjects given dexamethasone, oxytocin at 1, 2 or 4 mIU/min did not modify the rise in serum leptin.

    In plain wordsIn obese people given dexamethasone, oxytocin did not change the leptin rise.

    Peptide
    Oxytocin
    Outcome
    No significant changeDexamethasone-induced leptin rise with OT, obese subjects
    Study

    n = 6

    Comparator
    Dexamethasone with saline
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    1, 2 or 4 mIU/min · intravenous · 10 hAs given in this study (human).

    Source sentences

    Summary
    In the remaining 6 obese subjects, dex administration significantly increased serum leptin levels; however, the leptin response to dex was not modified by the concomitant infusion of 1, 2, or 4 mIU/min OT.
    1 context sentence
    Summary · context
    These findings led us to evaluate the secretory pattern of leptin in 12 obese patients in similar experimental conditions.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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