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Study · Animal study (in vivo) · rat · 2000

2 results

Antagonism of the melanocortin system reduces cold and mechanical allodynia in mononeuropathic rats.

Vrinten DH, Gispen WH, Groen GJ, Adan RA

The Journal of neuroscience : the official journal of the Society for Neuroscience1 Nov 2000Cited by 67 (Europe PMC)

PMID11050135 (opens in a new tab)PMCIDPMC6772745 (opens in a new tab)DOI10.1523/jneurosci.20-21-08131.2000 (opens in a new tab)PepBankPUB-11050135
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Summary

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Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with chronic constriction injury, intrathecal MTII increased sensitivity to mechanical stimulation.

    In plain wordsIn rats with nerve injury, melanotan II made them more sensitive to touch, not less.

    Peptide
    Melanotan II
    Outcome
    IncreaseMechanical sensitivity (allodynia) after MTII
    Study

    ratn: not reported in source

    chronic constriction injury of the sciatic nerve
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecal (cisterna magna)As given in this study (rat).

    Source sentences

    Summary
    administration of the MC4 receptor agonists MTII and d-Tyr-MTII primarily increases the sensitivity to mechanical and cold stimulation.
    1 context sentence
    Summary · context
    Furthermore, we investigated whether intrathecal administration (in the cisterna magna) of selective MC receptor ligands can affect the mechanical and cold allodynia associated with the CCI. Mechanical and cold allodynia were assessed by measuring withdrawal responses of the affected limb to von Fre…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with chronic constriction injury, intrathecal MTII increased sensitivity to cold stimulation.

    In plain wordsIn rats with nerve injury, melanotan II made them more sensitive to cold, not less.

    Peptide
    Melanotan II
    Outcome
    IncreaseCold sensitivity (allodynia) after MTII
    Study

    ratn: not reported in source

    chronic constriction injury of the sciatic nerve
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecal (cisterna magna)As given in this study (rat).

    Source sentences

    Summary
    administration of the MC4 receptor agonists MTII and d-Tyr-MTII primarily increases the sensitivity to mechanical and cold stimulation.
    1 context sentence
    Summary · context
    Furthermore, we investigated whether intrathecal administration (in the cisterna magna) of selective MC receptor ligands can affect the mechanical and cold allodynia associated with the CCI. Mechanical and cold allodynia were assessed by measuring withdrawal responses of the affected limb to von Fre…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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