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Study · In vitro (cells) · 2000

5 results

The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures.

Siméon A, Emonard H, Hornebeck W, Maquart FX

Life sciences1 Sept 2000Cited by 70 (Europe PMC)

PMID11045606 (opens in a new tab)DOI10.1016/s0024-3205(00)00803-1 (opens in a new tab)PepBankPUB-11045606
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In cultured dermal fibroblasts, GHK‑Cu increased MMP-2 levels in the conditioned media.

    In plain wordsIn cells, GHK‑Cu raised the amount of MMP-2 that fibroblasts released into the culture medium.

    Peptide
    GHK-Cu
    Outcome
    IncreaseMMP-2 levels in conditioned media
    Study

    n: not reported in source

    Dermal fibroblast cultures
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We showed that GHK-Cu increased MMP-2 levels in conditioned media of cultured fibroblasts.
    1 context sentence
    Summary · context
    The aim of this study was to determine the effects of GHK-Cu on MMP-2 synthesis by dermal fibroblasts in culture.
  2. 02LabIn vitro (cells)Mechanism

    In cultured dermal fibroblasts, the MMP-2 increase was reproduced by copper ions but not by the tripeptide GHK alone.

    In plain wordsIn cells, copper ions alone also raised MMP-2, but the GHK peptide alone did not.

    Peptide
    GHK-Cu
    Outcome
    Not applicableMMP-2 stimulation by copper ions or GHK alone
    Study

    n: not reported in source

    Dermal fibroblast cultures
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This effect was reproduced by copper ions but not by the tripeptide GHK alone.
    1 context sentence
    Summary · context
    The aim of this study was to determine the effects of GHK-Cu on MMP-2 synthesis by dermal fibroblasts in culture.
  3. 03LabIn vitro (cells)Efficacy outcome

    In cultured dermal fibroblasts, GHK‑Cu increased MMP-2 mRNA level.

    In plain wordsIn cells, GHK‑Cu raised MMP-2 gene message levels in fibroblasts.

    Peptide
    GHK-Cu
    Outcome
    IncreaseMMP-2 mRNA level
    Study

    n: not reported in source

    Dermal fibroblast cultures
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This stimulation was accompanied by an increase of MMP-2 mRNA level.
    1 context sentence
    Summary · context
    The aim of this study was to determine the effects of GHK-Cu on MMP-2 synthesis by dermal fibroblasts in culture.
  4. 04LabIn vitro (cells)Efficacy outcome

    In cultured dermal fibroblasts, GHK‑Cu increased secretion of TIMP-1.

    In plain wordsIn cells, GHK‑Cu raised the release of TIMP-1 by fibroblasts.

    Peptide
    GHK-Cu
    Outcome
    IncreaseTIMP-1 secretion
    Study

    n: not reported in source

    Dermal fibroblast cultures
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We also showed that GHK-Cu increased the secretion of the tissue inhibitors of metalloproteinases, TIMP-1 and TIMP-2.
    1 context sentence
    Summary · context
    The aim of this study was to determine the effects of GHK-Cu on MMP-2 synthesis by dermal fibroblasts in culture.
  5. 05LabIn vitro (cells)Efficacy outcome

    In cultured dermal fibroblasts, GHK‑Cu increased secretion of TIMP-2.

    In plain wordsIn cells, GHK‑Cu raised the release of TIMP-2 by fibroblasts.

    Peptide
    GHK-Cu
    Outcome
    IncreaseTIMP-2 secretion
    Study

    n: not reported in source

    Dermal fibroblast cultures
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We also showed that GHK-Cu increased the secretion of the tissue inhibitors of metalloproteinases, TIMP-1 and TIMP-2.
    1 context sentence
    Summary · context
    The aim of this study was to determine the effects of GHK-Cu on MMP-2 synthesis by dermal fibroblasts in culture.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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