[Effect of "vilon" on cirrhotically changed rat liver. Liver regeneration, and status of glycogen-forming function of hepatocytes].

Kudriavtseva MV, Bezborodkina NN, Sek EN, Shapiro IIa, Baranovskiĭ AIu, Kudriavtsev BN

Tsitologiia1 Jan 2000

PMID11033862PepBankPUB-11033862

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Activity measurement
In cirrhotic rats, Vilon increased hepatic glucose-6-phosphatase activity after treatment, while activity remained at cirrhotic levels in untreated rats.
In plain wordsIn rats with cirrhosis, Vilon increased liver glucose-6-phosphatase activity, while untreated rats retained cirrhotic levels.
Peptide
Vilon (KE)
Outcome
IncreaseHepatic glucose-6-phosphatase activity
Study
ratn: not reported in source
Carbon tetrachloride-induced liver cirrhosis
Comparator
Untreated cirrhotic rats
Outcome group
Liver fat and liver function · Liver
Studied dose
1.7 micrograms/kg daily · injection · 5 daysAs given in this study (rat).
Source sentences
Summary
In 2 weeks after the drug application, G6P activity being reduced in cirrhosis 1.2 times, elevated under effect of "Vilon".
2 context sentences(design, population, supporting numbers)
Summary · context
In non-treated rats the contents of TG and its fractions and of G6P activity remained at the level characteristic of the cirrhotic liver prior to "Vilon" administration.
Summary · context
The liver cirrhosis was produced by poisoning of rats for 4 months with carbon tetrachloride (CCl4). On the end of the poisoning with CCl4, one group of animals was not submitted to any further actions, whereas animals of the other group were injected "Vilon" (1.7 micrograms/kg) daily for 5 days.
Report a problemFND-1103386201
02AnimalAnimal study (in vivo)Efficacy outcome
In cirrhotic rats, hepatocyte total protein content was 4.7% higher with Vilon than without treatment.
In plain wordsIn rats with cirrhosis, liver cells contained 4.7% more total protein after Vilon treatment than in untreated rats.
Peptide
Vilon (KE)
Outcome
IncreaseHepatocyte total protein content
Study
ratn: not reported in source
Carbon tetrachloride-induced liver cirrhosis
Comparator
Untreated cirrhotic rats
Outcome group
Liver fat and liver function · Liver
Studied dose
1.7 micrograms/kg daily · injection · 5 daysAs given in this study (rat).
Measurements
Total protein content increase
4.7%
Vilon-treated versus untreated rats
Source sentences
Summary
"Vilon" has been shown to exert a weak stimulating effect on regeneration of the cirrotically altered rat liver: in hepatocytes of the second group of rats the total protein content and ploidy levels were higher than those in the first group by 4.7 and 11.5%, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
The liver cirrhosis was produced by poisoning of rats for 4 months with carbon tetrachloride (CCl4). On the end of the poisoning with CCl4, one group of animals was not submitted to any further actions, whereas animals of the other group were injected "Vilon" (1.7 micrograms/kg) daily for 5 days.
Report a problemFND-1103386204
03AnimalAnimal study (in vivo)Efficacy outcome
In cirrhotic rats, hepatocyte ploidy levels were 11.5% higher with Vilon than without treatment.
In plain wordsIn rats with cirrhosis, Vilon-treated liver cells had 11.5% higher ploidy levels than untreated cells.
Peptide
Vilon (KE)
Outcome
IncreaseHepatocyte ploidy levels
Study
ratn: not reported in source
Carbon tetrachloride-induced liver cirrhosis
Comparator
Untreated cirrhotic rats
Outcome group
Liver fat and liver function · Liver
Studied dose
1.7 micrograms/kg daily · injection · 5 daysAs given in this study (rat).
Measurements
Ploidy level increase
11.5%
Vilon-treated versus untreated rats
Source sentences
Summary
"Vilon" has been shown to exert a weak stimulating effect on regeneration of the cirrotically altered rat liver: in hepatocytes of the second group of rats the total protein content and ploidy levels were higher than those in the first group by 4.7 and 11.5%, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
The liver cirrhosis was produced by poisoning of rats for 4 months with carbon tetrachloride (CCl4). On the end of the poisoning with CCl4, one group of animals was not submitted to any further actions, whereas animals of the other group were injected "Vilon" (1.7 micrograms/kg) daily for 5 days.
Report a problemFND-1103386205

Studies that did not test the peptide alone2

In this study, Vilon (KE) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vilon (KE).

04AnimalNot a test of Vilon (KE) aloneAnimal study (in vivo)Activity measurement
In cirrhotic rats, hepatic glycogen phosphorylase activity did not differ from control values in either the Vilon-treated or untreated group.
In plain wordsIn rats with cirrhosis, liver glycogen phosphorylase activity stayed at control values in both Vilon-treated and untreated groups.
Peptide
Vilon (KE)
Outcome
No significant changeHepatic glycogen phosphorylase activity
Study
ratn: not reported in source
Carbon tetrachloride-induced liver cirrhosis
Comparator
Control values
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
In both groups of rats, GP and GS activities in the cirrhotically altered liver did not differ from their control values throughout the entire experiment.
1 context sentence(design, population, supporting numbers)
Summary · context
The liver cirrhosis was produced by poisoning of rats for 4 months with carbon tetrachloride (CCl4). On the end of the poisoning with CCl4, one group of animals was not submitted to any further actions, whereas animals of the other group were injected "Vilon" (1.7 micrograms/kg) daily for 5 days.
In this study, Vilon (KE) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vilon (KE).
Report a problemFND-1103386202
05AnimalNot a test of Vilon (KE) aloneAnimal study (in vivo)Activity measurement
In cirrhotic rats, hepatic glycogen synthase activity did not differ from control values in either the Vilon-treated or untreated group.
In plain wordsIn rats with cirrhosis, liver glycogen synthase activity stayed at control values in both Vilon-treated and untreated groups.
Peptide
Vilon (KE)
Outcome
No significant changeHepatic glycogen synthase activity
Study
ratn: not reported in source
Carbon tetrachloride-induced liver cirrhosis
Comparator
Control values
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
In both groups of rats, GP and GS activities in the cirrhotically altered liver did not differ from their control values throughout the entire experiment.
1 context sentence(design, population, supporting numbers)
Summary · context
The liver cirrhosis was produced by poisoning of rats for 4 months with carbon tetrachloride (CCl4). On the end of the poisoning with CCl4, one group of animals was not submitted to any further actions, whereas animals of the other group were injected "Vilon" (1.7 micrograms/kg) daily for 5 days.
In this study, Vilon (KE) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vilon (KE).
Report a problemFND-1103386203

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 17:05 UTC
Study results updated
Version 1
21 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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