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Study · Randomized controlled trial · n = 18 · 2000

4 results

Synergy of L-arginine and GHRP-2 stimulation of growth hormone in men and women: modulation by exercise.

Wideman L, Weltman JY, Patrie JT, Bowers CY, Shah N, Story S, Veldhuis JD, Weltman A

American journal of physiology. Regulatory, integrative and comparative physiology1 Oct 2000Cited by 20 (Europe PMC)

PMID11004017 (opens in a new tab)DOI10.1152/ajpregu.2000.279.4.r1467 (opens in a new tab)PepBankPUB-11004017
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In men and women during exercise, GHRP‑2 stimulated GH release more than saline.

    In plain wordsIn men and women who were exercising, GHRP‑2 raised GH release more than saline did.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH release with GHRP-2 versus saline during exercise
    Study

    n = 18

    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microg/kg bolus · intravenousAs given in this study (human).

    Source sentences

    Summary
    Similar to rest, exercise maintained the rank order (AG > G > A > S) of effective stimulation of GH release for the key response measures in men or women
    1 context sentence
    Summary · context
    Subjects (9 men and 9 early follicular phase women) completed 30 min of constant load aerobic exercise in combination with intravenous infusions of saline (S), A (30 g over 30 min), G (1 microg/kg bolus), or both (AG) in separate study sessions in randomly assigned order.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In men and women during exercise, L-arginine plus GHRP‑2 stimulated GH release more than L-arginine alone.

    In plain wordsIn men and women who were exercising, adding GHRP‑2 to L-arginine raised GH release more than L-arginine alone.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH release with L-arginine plus GHRP-2 versus L-arginine alone during exercise
    Study

    n = 18

    Comparator
    L-arginine alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microg/kg bolus · intravenousAs given in this study (human).

    Source sentences

    Summary
    Similar to rest, exercise maintained the rank order (AG > G > A > S) of effective stimulation of GH release for the key response measures in men or women
    1 context sentence
    Summary · context
    Subjects (9 men and 9 early follicular phase women) completed 30 min of constant load aerobic exercise in combination with intravenous infusions of saline (S), A (30 g over 30 min), G (1 microg/kg bolus), or both (AG) in separate study sessions in randomly assigned order.

Studies that did not test the peptide alone2

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

  1. 03HumanNot a test of GHRP-2 aloneRandomized controlled trialMechanism

    In men and women, exercise potentiated the individual stimulatory actions of L-arginine and GHRP‑2 on GH release.

    In plain wordsIn men and women, exercise made the GH-raising effect of GHRP‑2 and of L-arginine stronger.

    Peptide
    GHRP-2
    Outcome
    IncreaseEffect of exercise on the GH response to GHRP-2
    Study

    n = 18

    Comparator
    Rest
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Exercise potentiated the individual stimulatory actions of A and G
    1 context sentence
    Summary · context
    Subjects (9 men and 9 early follicular phase women) completed 30 min of constant load aerobic exercise in combination with intravenous infusions of saline (S), A (30 g over 30 min), G (1 microg/kg bolus), or both (AG) in separate study sessions in randomly assigned order.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  2. 04HumanNot a test of GHRP-2 aloneRandomized controlled trialMechanism

    In men and women, exercise blunted the relative magnitude of the supra-additive interaction of L-arginine and GHRP‑2 seen at rest.

    In plain wordsIn men and women, exercise reduced the extra GH release seen at rest when L-arginine and GHRP‑2 were given together.

    Peptide
    GHRP-2
    Outcome
    DecreaseSynergy of L-arginine and GHRP-2 during exercise
    Study

    n = 18

    Comparator
    Rest
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    while blunting the relative magnitude of the synergistic (supra-additive) interaction observed at rest.
    1 context sentence
    Summary · context
    Subjects (9 men and 9 early follicular phase women) completed 30 min of constant load aerobic exercise in combination with intravenous infusions of saline (S), A (30 g over 30 min), G (1 microg/kg bolus), or both (AG) in separate study sessions in randomly assigned order.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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