Significant reduction of the incidence of ovarian hyperstimulation syndrome (OHSS) by using the LHRH antagonist Cetrorelix (Cetrotide) in controlled ovarian stimulation for assisted reproduction.

Ludwig M, Felberbaum RE, Devroey P, Albano C, Riethmüller-Winzen H, Schüler A, Engel W, Diedrich K

Archives of gynecology and obstetrics1 Jul 2000Cited by 60 (Europe PMC)

PMID10985616DOI10.1007/pl00007479PepBankPUB-10985616

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanRandomized controlled trialSafety outcome
In IVF patients, grade II and III OHSS occurred less often with the cetrorelix protocol than with buserelin (1.1% versus 6.5%, p=0.03).
In plain wordsIn IVF patients, serious ovarian overstimulation occurred less often with the cetrorelix protocol than with buserelin.
Peptide
Cetrorelix
Outcome
DecreaseWHO grade II and III OHSS
Study
n = 273
Comparator
Buserelin protocol
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
OHSS grade II and III incidence
1.1%
Cetrorelix group
OHSS grade II and III incidence
6.5%
Buserelin group
Source sentences
Summary
The incidence of WHO degrees II and degrees III OHSS was significantly lower in the Cetrorelix than in the Buserelin group (1.1% vs. 6.5%, p=0.03).
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective, randomized study was performed to compare the efficiency of hormonal stimulation for IVF (in vitro fertilization) in either the long luteal protocol, using the LHRH agonist Buserelin, or the multiple dose LHRH antagonist protocol, using the LHRH antagonist Cetrorelix.
Summary · context
85 and 188 patients were recruited for the stimulation in the LHRH agonist and in the LHRH antagonist protocol, respectively.
Report a problemFND-1098561601
02HumanRandomized controlled trialSafety outcome
In IVF patients, hCG was withheld for threatening OHSS in 3 cetrorelix patients (1.6%) versus 5 buserelin patients (5.9%).
In plain wordsIn IVF patients, doctors withheld hCG for threatened ovarian overstimulation less often with cetrorelix than with buserelin.
Peptide
Cetrorelix
Outcome
DecreasehCG withheld for threatening OHSS
Study
n = 273
Comparator
Buserelin protocol
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
Patients not given hCG for threatening OHSS
3 patients
Cetrorelix group
Patients not given hCG for threatening OHSS
1.6%
Cetrorelix group
Patients not given hCG for threatening OHSS
5 patients
Buserelin group
Patients not given hCG for threatening OHSS
5.9%
Buserelin group
Source sentences
Summary
Additionally 3 patients in the Cetrorelix group (1.6%) and 5 patients in the Buserelin group (5.9%) did not receive hCG because of a threatening OHSS.
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective, randomized study was performed to compare the efficiency of hormonal stimulation for IVF (in vitro fertilization) in either the long luteal protocol, using the LHRH agonist Buserelin, or the multiple dose LHRH antagonist protocol, using the LHRH antagonist Cetrorelix.
Summary · context
85 and 188 patients were recruited for the stimulation in the LHRH agonist and in the LHRH antagonist protocol, respectively.
Report a problemFND-1098561602
03HumanRandomized controlled trialEfficacy outcome
In IVF patients, follicle maturation was more homogeneous with the cetrorelix protocol than with buserelin.
In plain wordsIn IVF patients, follicles matured more evenly with the cetrorelix protocol than with buserelin.
Peptide
Cetrorelix
Outcome
IncreaseFollicle maturation homogeneity
Study
n = 273
Comparator
Buserelin protocol
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The follicle maturation was more homogeneous in the Cetrorelix protocol, with less small follicles on the day of hCG administration but a similar number of oocyte cumulus complexes retrieved.
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective, randomized study was performed to compare the efficiency of hormonal stimulation for IVF (in vitro fertilization) in either the long luteal protocol, using the LHRH agonist Buserelin, or the multiple dose LHRH antagonist protocol, using the LHRH antagonist Cetrorelix.
Summary · context
85 and 188 patients were recruited for the stimulation in the LHRH agonist and in the LHRH antagonist protocol, respectively.
Report a problemFND-1098561603
04HumanRandomized controlled trialEfficacy outcome
In IVF patients, the cetrorelix protocol produced fewer small follicles on the hCG day than buserelin.
In plain wordsIn IVF patients, fewer small follicles remained on the hCG day with cetrorelix than with buserelin.
Peptide
Cetrorelix
Outcome
DecreaseSmall follicle number
Study
n = 273
Comparator
Buserelin protocol
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The follicle maturation was more homogeneous in the Cetrorelix protocol, with less small follicles on the day of hCG administration but a similar number of oocyte cumulus complexes retrieved.
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective, randomized study was performed to compare the efficiency of hormonal stimulation for IVF (in vitro fertilization) in either the long luteal protocol, using the LHRH agonist Buserelin, or the multiple dose LHRH antagonist protocol, using the LHRH antagonist Cetrorelix.
Summary · context
85 and 188 patients were recruited for the stimulation in the LHRH agonist and in the LHRH antagonist protocol, respectively.
Report a problemFND-1098561604
05HumanRandomized controlled trialEfficacy outcome
In IVF patients, the number of retrieved oocyte cumulus complexes was similar with cetrorelix and buserelin protocols.
In plain wordsIn IVF patients, the number of retrieved egg complexes was similar with cetrorelix and buserelin protocols.
Peptide
Cetrorelix
Outcome
Direction not reportedOocyte cumulus complexes retrieved
Study
n = 273
Comparator
Buserelin protocol
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The follicle maturation was more homogeneous in the Cetrorelix protocol, with less small follicles on the day of hCG administration but a similar number of oocyte cumulus complexes retrieved.
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective, randomized study was performed to compare the efficiency of hormonal stimulation for IVF (in vitro fertilization) in either the long luteal protocol, using the LHRH agonist Buserelin, or the multiple dose LHRH antagonist protocol, using the LHRH antagonist Cetrorelix.
Summary · context
85 and 188 patients were recruited for the stimulation in the LHRH agonist and in the LHRH antagonist protocol, respectively.
Report a problemFND-1098561605
06HumanRandomized controlled trialEfficacy outcome
In IVF patients, pregnancy rates did not differ significantly between cetrorelix and buserelin protocols (22% versus 26%).
In plain wordsIn IVF patients, pregnancy rates did not differ significantly between cetrorelix and buserelin protocols.
Peptide
Cetrorelix
Outcome
No significant changePregnancy rate per cycle
Study
n: not reported in source
Comparator
Buserelin protocol
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
Pregnancy rate per cycle
22%
Cetrorelix protocol
Pregnancy rate per cycle
26%
Buserelin protocol
Source sentences
Summary
The pregnancy rates per cycle were not significantly different in the Cetrorelix and Buserelin protocol (22% vs. 26%).
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective, randomized study was performed to compare the efficiency of hormonal stimulation for IVF (in vitro fertilization) in either the long luteal protocol, using the LHRH agonist Buserelin, or the multiple dose LHRH antagonist protocol, using the LHRH antagonist Cetrorelix.
Summary · context
85 and 188 patients were recruited for the stimulation in the LHRH agonist and in the LHRH antagonist protocol, respectively.
Report a problemFND-1098561606

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Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedNot applicableNCT01669291

Effect of GnRH Antagonist vs Agonist Long on IVF Outcome, Peak Estradiol Level,and Duration of Stimulation

Main Line Fertility Centern = 43Jul 2012 to May 2014

Fertility

Trial page ClinicalTrials.govUpdated 4 Jun 2014

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

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