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Study · Animal study (in vivo) · cow · 2000

4 results

Intramammary infusion of insulin or long R3 insulin-like growth factor-I did not increase milk protein yield in dairy cows.

Mackle TR, Dwyer DA, Bauman DE

Journal of dairy science1 Aug 2000Cited by 9 (Europe PMC)

PMID10984150 (opens in a new tab)DOI10.3168/jds.s0022-0302(00)75044-2 (opens in a new tab)PepBankPUB-10984150
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In well-fed dairy cows, intramammary long R3 IGF-I did not enhance milk protein yield, and protein yield was slightly lower.

    In plain wordsIn dairy cows, infusing an IGF-I analogue into the udder did not raise milk protein yield. Yield was slightly lower.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseMilk protein yield
    Study

    cown = 4

    Lactating dairy cows
    Outcome group
    Lactation and milk synthesis · Metabolic and weight
    Studied dose
    Dose not stated · intramammary infusionAs given in this study (cow).

    Source sentences

    Summary
    yields of milk, protein, and fat were slightly lower following long R3 insulin-like growth factor-I treatment.
    2 context sentences
    Summary · context
    However, in experiment 2 neither hormone enhanced milk protein yield when administered using an intramammary technique.
    Summary · context
    Two experiments investigated the regulation of milk protein synthesis in well-fed cows (n = 4) using 1) a hyperinsulinemic-euglycemic clamp and 2) intramammary infusion of insulin or long R3 insulin-like growth factor-I plus supplementary amino acids.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In well-fed dairy cows, milk yield was slightly lower after intramammary long R3 IGF-I.

    In plain wordsIn dairy cows, milk yield was slightly lower after an IGF-I analogue was infused into the udder.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseMilk yield
    Study

    cown = 4

    Lactating dairy cows
    Outcome group
    Lactation and milk synthesis · Metabolic and weight
    Studied dose
    Dose not stated · intramammary infusionAs given in this study (cow).

    Source sentences

    Summary
    yields of milk, protein, and fat were slightly lower following long R3 insulin-like growth factor-I treatment.
    1 context sentence
    Summary · context
    Two experiments investigated the regulation of milk protein synthesis in well-fed cows (n = 4) using 1) a hyperinsulinemic-euglycemic clamp and 2) intramammary infusion of insulin or long R3 insulin-like growth factor-I plus supplementary amino acids.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In well-fed dairy cows, milk fat yield was slightly lower after intramammary long R3 IGF-I.

    In plain wordsIn dairy cows, milk fat yield was slightly lower after an IGF-I analogue was infused into the udder.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseMilk fat yield
    Study

    cown = 4

    Lactating dairy cows
    Outcome group
    Lactation and milk synthesis · Metabolic and weight
    Studied dose
    Dose not stated · intramammary infusionAs given in this study (cow).

    Source sentences

    Summary
    yields of milk, protein, and fat were slightly lower following long R3 insulin-like growth factor-I treatment.
    1 context sentence
    Summary · context
    Two experiments investigated the regulation of milk protein synthesis in well-fed cows (n = 4) using 1) a hyperinsulinemic-euglycemic clamp and 2) intramammary infusion of insulin or long R3 insulin-like growth factor-I plus supplementary amino acids.
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In well-fed dairy cows, somatic cell count increased after intramammary long R3 IGF-I.

    In plain wordsIn dairy cows, the milk cell count rose after an IGF-I analogue was infused into the udder.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseSomatic cell count
    Study

    cown = 4

    Lactating dairy cows
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intramammary infusionAs given in this study (cow).

    Source sentences

    Summary
    This could be associated with an increase in somatic cell count, which occurred following long R3 insulin-like growth factor-I treatment.
    1 context sentence
    Summary · context
    Two experiments investigated the regulation of milk protein synthesis in well-fed cows (n = 4) using 1) a hyperinsulinemic-euglycemic clamp and 2) intramammary infusion of insulin or long R3 insulin-like growth factor-I plus supplementary amino acids.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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