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Study · Animal study (in vivo) · rat · 2000

3 results

Pharmacokinetics of new nootropic acylprolyldipeptide and its penetration across the blood-brain barrier after oral administration.

Boiko SS, Ostrovskaya RU, Zherdev VP, Korotkov SA, Gudasheva TA, Voronina TA, Seredenin SB

Bulletin of experimental biology and medicine1 Apr 2000Cited by 4 (Europe PMC)

PMID10977920 (opens in a new tab)DOI10.1007/bf02439270 (opens in a new tab)PepBankPUB-10977920
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, orally administered GVS-111 was absorbed in the gastrointestinal tract.

    In plain wordsIn rats, oral GVS-111 was absorbed through the digestive tract.

    Peptide
    Noopept (omberacetam)
    Outcome
    Not applicableGastrointestinal absorption
    Study

    ratn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · oralAs given in this study (rat).

    Source sentences

    Summary
    It was found that the dipeptide is absorbed in the gastrointestinal tract, enters the circulation, and penetrates through the blood-brain barrier in an unmodified state.
    1 context sentence
    Summary · context
    Pharmacokinetics of GVS-111, a new acylprolyldipeptide with nootropic properties and its penetration across the blood-brain barrier were studied in rats using HPLC.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, orally administered GVS-111 entered the circulation.

    In plain wordsIn rats, oral GVS-111 entered the bloodstream.

    Peptide
    Noopept (omberacetam)
    Outcome
    Not applicableEntry into circulation
    Study

    ratn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · oralAs given in this study (rat).

    Source sentences

    Summary
    It was found that the dipeptide is absorbed in the gastrointestinal tract, enters the circulation, and penetrates through the blood-brain barrier in an unmodified state.
    1 context sentence
    Summary · context
    Pharmacokinetics of GVS-111, a new acylprolyldipeptide with nootropic properties and its penetration across the blood-brain barrier were studied in rats using HPLC.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, orally administered GVS-111 crossed the blood-brain barrier in an unmodified state.

    In plain wordsIn rats, oral GVS-111 crossed the blood-brain barrier without modification.

    Peptide
    Noopept (omberacetam)
    Outcome
    Not applicableBlood-brain barrier penetration
    Study

    ratn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · oralAs given in this study (rat).

    Source sentences

    Summary
    It was found that the dipeptide is absorbed in the gastrointestinal tract, enters the circulation, and penetrates through the blood-brain barrier in an unmodified state.
    1 context sentence
    Summary · context
    Pharmacokinetics of GVS-111, a new acylprolyldipeptide with nootropic properties and its penetration across the blood-brain barrier were studied in rats using HPLC.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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