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Study · Animal study (in vivo) · drosophila melanogaster · 2000

2 results

Effect of pineal tetrapeptide on antioxidant defense in Drosophila melanogaster.

Khavinson VK, Myl'nikov SV

Bulletin of experimental biology and medicine1 Apr 2000Cited by 8 (Europe PMC)

PMID10977918 (opens in a new tab)DOI10.1007/bf02439268 (opens in a new tab)PepBankPUB-10977918
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In Drosophila melanogaster, Epithalon was shown to be a potent modulator of antioxidant defense, assessed by catalase activity and conjugated hydroperoxides.

    In plain wordsIn fruit flies, epithalon changed the antioxidant defense system strongly; the abstract gives no direction.

    Peptide
    Epitalon
    Outcome
    Direction not reportedModulation of antioxidant defense
    Study

    Drosophila melanogastern: not reported in source

    Highly inbred lines differing in reproductive functions
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was shown that Epithalon is a potent modulator of the antioxidant defense
    1 context sentence
    Summary · context
    Effects of synthetic pineal tetrapeptide L-Ala-L-Glu-L-Asp-L-Glu (Epithalon) on specific catalase activity and the content of conjugated hydroperoxides in highly inbred Drosophila melanogaster lines differing in reproductive functions were studied.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In Drosophila melanogaster, the biological activity of Epithalon was 1000-fold higher than that of the complex pineal peptide preparation Epithalamin.

    In plain wordsIn fruit flies, epithalon was far more active than the complex pineal peptide preparation epithalamin.

    Peptide
    Epitalon
    Outcome
    Not applicablePotency relative to Epithalamin
    Study

    Drosophila melanogastern: not reported in source

    Highly inbred lines differing in reproductive functions
    Comparator
    Epithalamin
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Measurements

    Relative biological activity vs Epithalamin
    1000 fold
    Epithalon

    Source sentences

    Summary
    whose biological activity 1000-fold surpasses that of the complex pineal peptide preparation Epithalamin.
    1 context sentence
    Summary · context
    Effects of synthetic pineal tetrapeptide L-Ala-L-Glu-L-Asp-L-Glu (Epithalon) on specific catalase activity and the content of conjugated hydroperoxides in highly inbred Drosophila melanogaster lines differing in reproductive functions were studied.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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