In chicken neuronal cultures with protein synthesis blocked, Cerebrolysin preserved more MAP2 than untreated controls.
In plain wordsIn cells from chickens, Cerebrolysin preserved more MAP2 than untreated controls when protein synthesis was blocked.
- Peptide
- Cerebrolysin
- Outcome
- IncreaseMAP2 content after protein synthesis blockade
- Study
chickenn: not reported in source
Primary cultured chicken neurons- Comparator
- Untreated controls
- Outcome group
- Neuroprotection · Nervous system and cognition
- Studied dose
- Dose not stated
Source sentences
Cerebrolysin treated cells contained more MAP2 than untreated controls proving that the drug protects MAP2 independently from de novo synthesis
2 context sentences(design, population, supporting numbers)
In other experiments the protein synthesis of Cerebrolysin treated and untreated cells was blocked with cycloheximide at that moment when all cells exhibited the same MAP2 content.
After the following MAP2 degradation phase--i.e. after eight days in vitro--the MAP2 contents were determined by western blotting.