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Study · In vitro (cells) · 2000

5 results

Post-transcription modulation of the blood-brain barrier GLUT1 glucose transporter by brain-derived factors.

Boado RJ

Journal of neural transmission. Supplementum1 Jan 2000Cited by 4 (Europe PMC)

PMID10961437 (opens in a new tab)DOI10.1007/978-3-7091-6781-6_27 (opens in a new tab)PepBankPUB-10961437
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cultured brain endothelial cells, Cerebrolysin increased GLUT1 expression through mRNA stabilization.

    In plain wordsIn cells, Cerebrolysin increased GLUT1 expression through stabilization of its RNA.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseGLUT1 expression via mRNA stabilization
    Study

    n: not reported in source

    Brain endothelial cultured cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Brain-derived peptides or factors in the brain-derived preparation Cerebrolysin (Cl, EBEWE, Austria) increase the expression of the blood-brain barrier (BBB) GLUT1 glucose transporter via mRNA stabilization.
    1 context sentence
    Summary · context
    The p88 TAF was detected in cytosol of brain endothelial cultured cells (ECL) as a duplex of molecular weight of approximately 88 kDa, which were defined A and B (high and low MW, respectively).
  2. 02LabIn vitro (cells)Mechanism

    In brain endothelial cells, Cerebrolysin increased GLUT1-stabilizing p88 complex B abundance.

    In plain wordsIn cells, Cerebrolysin increased the GLUT1-stabilizing p88 complex B.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseP88 complex B abundance
    Study

    n: not reported in source

    Brain endothelial cultured cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cl markedly increased the abundance of the BBB-GLUT1 p88 TAF (complex B) in ECL cells, without changes in the levels of the p88 complex A.
    1 context sentence
    Summary · context
    The p88 TAF was detected in cytosol of brain endothelial cultured cells (ECL) as a duplex of molecular weight of approximately 88 kDa, which were defined A and B (high and low MW, respectively).
  3. 03LabIn vitro (cells)Mechanism

    In brain endothelial cells, Cerebrolysin did not change p88 complex A levels.

    In plain wordsIn cells, Cerebrolysin did not change p88 complex A levels.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeP88 complex A levels
    Study

    n: not reported in source

    Brain endothelial cultured cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cl markedly increased the abundance of the BBB-GLUT1 p88 TAF (complex B) in ECL cells, without changes in the levels of the p88 complex A.
    1 context sentence
    Summary · context
    The p88 TAF was detected in cytosol of brain endothelial cultured cells (ECL) as a duplex of molecular weight of approximately 88 kDa, which were defined A and B (high and low MW, respectively).
  4. 04LabIn vitro (cells)Mechanism

    In brain endothelial cells, Cerebrolysin did not induce destabilizing p44 TAF expression.

    In plain wordsIn cells, Cerebrolysin did not induce the destabilizing p44 factor.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeP44 TAF expression
    Study

    n: not reported in source

    Brain endothelial cultured cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cl per se, did not bind to the GLUT1 mRNA, nor induced the expression of the destabilizing p44 TAF.
    1 context sentence
    Summary · context
    The p88 TAF was detected in cytosol of brain endothelial cultured cells (ECL) as a duplex of molecular weight of approximately 88 kDa, which were defined A and B (high and low MW, respectively).
  5. 05LabIn vitro (cell-free)Mechanism

    In laboratory experiments, Cerebrolysin did not bind GLUT1 mRNA.

    In plain wordsIn lab tests, Cerebrolysin did not bind GLUT1 RNA.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeBinding to GLUT1 mRNA
    Study

    n: not reported in source

    GLUT1 mRNA binding assay
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cl per se, did not bind to the GLUT1 mRNA, nor induced the expression of the destabilizing p44 TAF.
    1 context sentence
    Summary · context
    The p88 TAF was detected in cytosol of brain endothelial cultured cells (ECL) as a duplex of molecular weight of approximately 88 kDa, which were defined A and B (high and low MW, respectively).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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