Skip to content

Study · Animal study (in vivo) · rat · 2000

2 results

Melanocortin signaling is decreased during neurotoxin-induced transient hyperphagia and increased body-weight gain.

Dube MG, Pu S, Kalra SP, Kalra PS

Peptides1 Jun 2000Cited by 12 (Europe PMC)

PMID10958999 (opens in a new tab)DOI10.1016/s0196-9781(00)00210-2 (opens in a new tab)PepBankPUB-10958999
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats given colchicine in the ventromedial nucleus, intracerebroventricular MTII prevented the hyperphagia.

    In plain wordsIn rats with induced overeating, melanotan II prevented the overeating.

    Peptide
    Melanotan II
    Outcome
    DecreaseHyperphagia after colchicine
    Study

    ratn: not reported in source

    colchicine-induced transient hyperphagia
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    intracerebroventricular injection of the MC3/MC4 melanocortin receptor agonist, MTII, prevented the hyperphagia and BW gain.
    1 context sentence
    Summary · context
    COL (4 microg/0.5 microl saline) or saline was microinjected bilaterally into the ventromedial nucleus of adult male rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats given colchicine in the ventromedial nucleus, intracerebroventricular MTII prevented the body weight gain.

    In plain wordsIn rats with induced overeating, melanotan II prevented the weight gain.

    Peptide
    Melanotan II
    Outcome
    DecreaseBody weight gain after colchicine
    Study

    ratn: not reported in source

    colchicine-induced transient hyperphagia
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    intracerebroventricular injection of the MC3/MC4 melanocortin receptor agonist, MTII, prevented the hyperphagia and BW gain.
    1 context sentence
    Summary · context
    COL (4 microg/0.5 microl saline) or saline was microinjected bilaterally into the ventromedial nucleus of adult male rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.