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Study · Animal study (in vivo) · mouse · 2000

3 results

Role of the melanocortin-4 receptor in metabolic rate and food intake in mice.

Chen AS, Metzger JM, Trumbauer ME, Guan XM, Yu H, Frazier EG, Marsh DJ, Forrest MJ, Gopal-Truter S, Fisher J, Camacho RE, Strack AM and 4 more

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Mellin TN, MacIntyre DE, Chen HY, Van der Ploeg LH

Transgenic research1 Apr 2000Cited by 202 (Europe PMC)

PMID10951699 (opens in a new tab)DOI10.1023/a:1008983615045 (opens in a new tab)PepBankPUB-10951699
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In wildtype mice, intraperitoneal melanotan II increased metabolic rate.

    In plain wordsIn mice, melanotan II raised metabolic rate.

    Peptide
    Melanotan II
    Outcome
    IncreaseMetabolic rate in wildtype mice
    Study

    mousen: not reported in source

    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Intraperitoneal administration of the non-selective MC-R agonist melanotan II (MT-II; a cyclic heptapeptide) increases metabolic rate in wildtype mice
    1 context sentence
    Summary · context
    We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In MC-4R knockout mice, melanotan II did not change metabolic rate.

    In plain wordsIn mice lacking the MC-4R receptor, melanotan II did not change metabolic rate.

    Peptide
    Melanotan II
    Outcome
    No significant changeMetabolic rate in MC-4R knockout mice
    Study

    mousen: not reported in source

    MC-4R knockout mice
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    MC-4R knockout mice are insensitive to the effects of MT-II on metabolic rate.
    1 context sentence
    Summary · context
    We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In MC-4R knockout mice, melanotan II did not reduce food intake.

    In plain wordsIn mice lacking the MC-4R receptor, melanotan II did not reduce food intake.

    Peptide
    Melanotan II
    Outcome
    No significant changeFood intake in MC-4R knockout mice
    Study

    mousen: not reported in source

    MC-4R knockout mice
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    MC-4R knockout mice are also insensitive to the effects of MT-II on reducing food intake.
    1 context sentence
    Summary · context
    We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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