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Study · Animal study (in vivo) · rat · 2000

3 results

Six-month daily administration of parathyroid hormone and parathyroid hormone-related protein peptides to adult ovariectomized rats markedly enhances bone mass and biomechanical properties: a comparison of human parathyroid hormone 1-34, parathyroid hormone-related protein 1-36, and SDZ-parathyroid hormone 893.

Stewart AF, Cain RL, Burr DB, Jacob D, Turner CH, Hock JM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research1 Aug 2000Cited by 96 (Europe PMC)

PMID10934650 (opens in a new tab)DOI10.1359/jbmr.2000.15.8.1517 (opens in a new tab)PepBankPUB-10934650
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, PTH improved the reported composite of bone mass, histomorphometry, biomechanics, and formation indices versus controls.

    In plain wordsIn rats, PTH improved reported bone measures compared with controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSkeletal anabolic response
    Study

    ratn: not reported in source

    Adult ovariectomized rats
    Comparator
    Vehicle-treated OVX and sham OVX controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 micrograms/kg per day · 6 monthsAs given in this study (rat).

    Source sentences

    Summary
    Bone mass, as assessed by ash weight and densitometry, bone histomorphometry, biomechanical properties at trabecular and cortical sites, and indices of bone formation markedly increased in all three PTH/PTHrP peptide-treated groups as compared with controls.
    1 context sentence
    Summary · context
    A 6-month study was performed in which adult (6-month-old) vehicle-treated ovariectomized (OVX) and sham OVX rats were compared with OVX rats receiving 40 micrograms/kg per day of either PTH(1-34), PTHrP(1-36), or PTH-SDZ-893.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, the general skeletal improvement with PTH ranked below SDZ-PTH-893.

    In plain wordsIn rats, PTH produced less general skeletal improvement than SDZ-PTH-893.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseRelative skeletal anabolic response
    Study

    ratn: not reported in source

    Adult ovariectomized rats
    Comparator
    SDZ-PTH-893
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 micrograms/kg per day · 6 monthsAs given in this study (rat).

    Source sentences

    Summary
    In general, this improvement followed a rank order of SDZ-PTH-893 > PTH > PTHrP.
    2 context sentences
    Summary · context
    Bone mass, as assessed by ash weight and densitometry, bone histomorphometry, biomechanical properties at trabecular and cortical sites, and indices of bone formation markedly increased in all three PTH/PTHrP peptide-treated groups as compared with controls.
    Summary · context
    A 6-month study was performed in which adult (6-month-old) vehicle-treated ovariectomized (OVX) and sham OVX rats were compared with OVX rats receiving 40 micrograms/kg per day of either PTH(1-34), PTHrP(1-36), or PTH-SDZ-893.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, the general skeletal improvement with PTH ranked above PTHrP.

    In plain wordsIn rats, PTH produced greater general skeletal improvement than PTHrP.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseRelative skeletal anabolic response
    Study

    ratn: not reported in source

    Adult ovariectomized rats
    Comparator
    PTHrP(1-36)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 micrograms/kg per day · 6 monthsAs given in this study (rat).

    Source sentences

    Summary
    In general, this improvement followed a rank order of SDZ-PTH-893 > PTH > PTHrP.
    2 context sentences
    Summary · context
    Bone mass, as assessed by ash weight and densitometry, bone histomorphometry, biomechanical properties at trabecular and cortical sites, and indices of bone formation markedly increased in all three PTH/PTHrP peptide-treated groups as compared with controls.
    Summary · context
    A 6-month study was performed in which adult (6-month-old) vehicle-treated ovariectomized (OVX) and sham OVX rats were compared with OVX rats receiving 40 micrograms/kg per day of either PTH(1-34), PTHrP(1-36), or PTH-SDZ-893.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials2

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

2 trials · 2 completed · 2 with posted results · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 2Results postedNCT00853723

Comparison Study of PTHrP and PTH to Treat Osteoporosis

University of Pittsburghn = 105May 2009 to Jun 2012

Osteoporosis

Trial pageClinicalTrials.govUpdated 24 Mar 2016
CompletedEarly phase 1Results postedNCT00377312

7 Day Continuous Parathyroid Hormone IV Infusion

University of Pittsburghn = 11Sept 2006 to Dec 2007

Osteoporosis · Bone Diseases, Endocrine · Hyperparathyroidism

Trial pageClinicalTrials.govUpdated 22 Mar 2016

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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