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Study · Animal study (in vivo) · mouse · 2000

7 results

Effects of infantile thymectomy on ovarian functions and gonadotrophin-induced ovulation in prepubertal mice: role of thymulin.

García L, Hinojosa L, Domínguez R, Chavira R, Rosas P

The Journal of endocrinology1 Aug 2000Cited by 16 (Europe PMC)

PMID10927627 (opens in a new tab)DOI10.1677/joe.0.1660381 (opens in a new tab)PepBankPUB-10927627
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized mice, thymulin advanced puberty onset.

    In plain wordsIn mice with the thymus removed, thymulin advanced puberty onset.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreasePuberty onset
    Study

    mousen: not reported in source

    infantile thymectomized prepubertal mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    12 ng/g body weightAs given in this study (mouse).

    Source sentences

    Summary
    Injection of thymulin (12 ng/g body weight) to Tx-10 mice resulted in an earlier onset of puberty, a decrease in the weights of ovaries and uterus, and an increase in serum 17beta-oestradiol concentrations.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized mice, thymulin decreased ovarian weight.

    In plain wordsIn mice with the thymus removed, thymulin decreased ovarian weight.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseOvarian weight
    Study

    mousen: not reported in source

    infantile thymectomized prepubertal mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    12 ng/g body weightAs given in this study (mouse).

    Source sentences

    Summary
    Injection of thymulin (12 ng/g body weight) to Tx-10 mice resulted in an earlier onset of puberty, a decrease in the weights of ovaries and uterus, and an increase in serum 17beta-oestradiol concentrations.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized mice, thymulin decreased uterine weight.

    In plain wordsIn mice with the thymus removed, thymulin decreased uterine weight.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseUterine weight
    Study

    mousen: not reported in source

    infantile thymectomized prepubertal mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    12 ng/g body weightAs given in this study (mouse).

    Source sentences

    Summary
    Injection of thymulin (12 ng/g body weight) to Tx-10 mice resulted in an earlier onset of puberty, a decrease in the weights of ovaries and uterus, and an increase in serum 17beta-oestradiol concentrations.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized mice, thymulin increased serum 17beta-oestradiol concentrations.

    In plain wordsIn mice with the thymus removed, thymulin increased blood oestradiol levels.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseSerum 17beta-oestradiol
    Study

    mousen: not reported in source

    infantile thymectomized prepubertal mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    12 ng/g body weightAs given in this study (mouse).

    Source sentences

    Summary
    Injection of thymulin (12 ng/g body weight) to Tx-10 mice resulted in an earlier onset of puberty, a decrease in the weights of ovaries and uterus, and an increase in serum 17beta-oestradiol concentrations.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized mice receiving PMSG and hCG, daily thymulin increased the number of ova shed.

    In plain wordsIn mice with the thymus removed, adding daily thymulin to PMSG and hCG increased the number of eggs released.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseOva shed during PMSG-hCG treatment
    Study

    mousen: not reported in source

    infantile thymectomized prepubertal mice
    Comparator
    PMSG-hCG treatment without thymulin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    When these animals were injected daily with thymulin, an increase in the number of ova shed and serum 17beta-oestradiol concentrations was observed.
    1 context sentence
    Summary · context
    In Tx-10 mice the sequential injection of PMSG (1 IU) and human chorionic gonadotrophin (hCG) (3 IU) resulted in ovulation, but the number of ova shed was lower than in controls.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized mice receiving PMSG and hCG, daily thymulin increased serum 17beta-oestradiol concentrations.

    In plain wordsIn mice with the thymus removed, adding daily thymulin to PMSG and hCG increased blood oestradiol levels.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseSerum 17beta-oestradiol during PMSG-hCG treatment
    Study

    mousen: not reported in source

    infantile thymectomized prepubertal mice
    Comparator
    PMSG-hCG treatment without thymulin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    When these animals were injected daily with thymulin, an increase in the number of ova shed and serum 17beta-oestradiol concentrations was observed.
    1 context sentence
    Summary · context
    In Tx-10 mice the sequential injection of PMSG (1 IU) and human chorionic gonadotrophin (hCG) (3 IU) resulted in ovulation, but the number of ova shed was lower than in controls.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In thymectomized mice receiving PMSG and hCG, thymulin significantly increased uterine weight.

    In plain wordsIn mice with the thymus removed, adding thymulin to PMSG and hCG increased uterine weight.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseUterine weight during PMSG-hCG treatment
    Study

    mousen: not reported in source

    infantile thymectomized prepubertal mice
    Comparator
    PMSG-hCG treatment without thymulin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymulin injection in PMSG-hCG-treated Tx-10 mice provoked a significant increase in uterine weight.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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