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Study · Animal study (in vivo) · rat · 2000

2 results

A novel mechanism for skeletal resistance in uremia.

Slatopolsky E, Finch J, Clay P, Martin D, Sicard G, Singer G, Gao P, Cantor T, Dusso A

Kidney international1 Aug 2000Cited by 222 (Europe PMC)

PMID10916099 (opens in a new tab)DOI10.1046/j.1523-1755.2000.00222.x (opens in a new tab)PepBankPUB-10916099
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In parathyroidectomized rats, PTH 1‑84 increased plasma calcium by 0.65 mg/dL two hours after treatment.

    In plain wordsIn rats without parathyroid glands, PTH 1‑84 increased blood calcium by 0.65 mg/dL two hours after treatment.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreasePlasma calcium
    Study

    ratn: not reported in source

    parathyroidectomized rats fed a calcium-deficient diet
    Outcome group
    Electrolyte balance · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Plasma calcium increase
    0.65 mg/dL
    two hours after PTH 1-84

    Source sentences

    Summary
    Plasma calcium was increased (0.65 mg/dL) two hours after 1-84 PTH treatment, while 7-84 PTH had no effect.
    1 context sentence
    Summary · context
    In parathyroidectomized rats fed a calcium-deficient diet, 7-84 PTH was not only biologically inactive, but had antagonistic effects on 1-84 PTH in bone.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In normal rats, PTH 1‑84 increased renal fractional phosphate excretion from 11.9 to 27.7% (P < 0.001).

    In plain wordsIn normal rats, PTH 1‑84 increased the fraction of phosphate excreted by kidneys from 11.9 to 27.7%.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreaseRenal fractional phosphate excretion
    Study

    ratn: not reported in source

    normal rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Measurements

    Renal fractional phosphate excretion
    11.9%
    before treatment
    Renal fractional phosphate excretion
    27.7%
    after PTH 1-84

    Source sentences

    Summary
    In normal rats, the administration of 1-84 PTH increased renal fractional excretion of phosphate (11.9 to 27.7%, P < 0.001).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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