Immunomodulatory potential of thymulin-Zn(2+) in the alveolar epithelium: amelioration of endotoxin-induced cytokine release and partial amplification of a cytoprotective IL-10-sensitive pathway.

Haddad JJ, Land SC, Saadé NE, Safieh-Garabedian B

Biochemical and biophysical research communications1 Aug 2000Cited by 18 (Europe PMC)

PMID10913367DOI10.1006/bbrc.2000.3155PepBankPUB-10913367

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

4 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In fetal alveolar epithelial cells, thymulin reduced endotoxin-induced IL-1 beta release in a dose-dependent manner.
In plain wordsIn cells, thymulin reduced endotoxin-induced IL-1 beta release depending on dose.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseEndotoxin-induced IL-1 beta release
Study
n: not reported in source
fetal alveolar type II epithelial cells
Outcome group
Inflammation markers · Respiratory
Studied dose
Dose not stated
Measurements
IC50
657 ng. ml(-1)
IL-1 beta release
Source sentences
Summary
Thymulin selectively ameliorated, in a dose-dependent manner, the endotoxin-induced release of IL-1 beta (IC(50) = 657 ng. ml(-1)), but showed no inhibitory effect on IL-6 and TNF-alpha.
1 context sentence(design, population, supporting numbers)
Summary · context
In an in vitro model of fetal alveolar type II epithelial cells, we investigated the exhibition of an anti-inflammatory activity of this peptide hormone.
Report a problemFND-1091336701
02LabIn vitro (cells)Mechanism
In fetal alveolar epithelial cells, thymulin did not inhibit endotoxin-induced IL-6 release.
In plain wordsIn cells, thymulin did not inhibit endotoxin-induced IL-6 release.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeEndotoxin-induced IL-6 release
Study
n: not reported in source
fetal alveolar type II epithelial cells
Outcome group
Inflammation markers · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
Thymulin selectively ameliorated, in a dose-dependent manner, the endotoxin-induced release of IL-1 beta (IC(50) = 657 ng. ml(-1)), but showed no inhibitory effect on IL-6 and TNF-alpha.
1 context sentence(design, population, supporting numbers)
Summary · context
In an in vitro model of fetal alveolar type II epithelial cells, we investigated the exhibition of an anti-inflammatory activity of this peptide hormone.
Report a problemFND-1091336702
03LabIn vitro (cells)Mechanism
In fetal alveolar epithelial cells, thymulin did not inhibit endotoxin-induced TNF-alpha release.
In plain wordsIn cells, thymulin did not inhibit endotoxin-induced TNF-alpha release.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeEndotoxin-induced TNF-alpha release
Study
n: not reported in source
fetal alveolar type II epithelial cells
Outcome group
Inflammation markers · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
Thymulin selectively ameliorated, in a dose-dependent manner, the endotoxin-induced release of IL-1 beta (IC(50) = 657 ng. ml(-1)), but showed no inhibitory effect on IL-6 and TNF-alpha.
1 context sentence(design, population, supporting numbers)
Summary · context
In an in vitro model of fetal alveolar type II epithelial cells, we investigated the exhibition of an anti-inflammatory activity of this peptide hormone.
Report a problemFND-1091336703
04LabIn vitro (cells)Mechanism
In fetal alveolar epithelial cells, analysis of thymulin responses implicated an IL-10-sensitive anti-inflammatory pathway.
In plain wordsIn cells, analysis of thymulin responses implicated an IL-10-sensitive anti-inflammatory pathway.
Peptide
Thymulin (serum thymic factor)
Outcome
Not applicableIL-10-sensitive pathway
Study
n: not reported in source
fetal alveolar type II epithelial cells
Outcome group
Receptor activity and mechanism · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
Analysis of whether thymulin is up-regulating a counterpart anti-inflammatory signaling loop revealed the involvement of an IL-10-sensitive pathway.
1 context sentence(design, population, supporting numbers)
Summary · context
In an in vitro model of fetal alveolar type II epithelial cells, we investigated the exhibition of an anti-inflammatory activity of this peptide hormone.
Report a problemFND-1091336707

Studies that did not test the peptide alone3

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

05LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Mechanism
In fetal alveolar epithelial cells, zinc amplified thymulin effects on IL-1 beta.
In plain wordsIn cells, zinc increased thymulin effects on IL-1 beta.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseIL-1 beta response with zinc
Study
n: not reported in source
fetal alveolar type II epithelial cells
Outcome group
Inflammation markers · Respiratory
Measurements
IC50
< 0.1 ng. ml(-1)
IL-1 beta release with thymulin and 100 microM zinc
Source sentences
Summary
This cation (100 microM) amplified the effect of thymulin on IL-1 beta and TNF-alpha (IC(50) < 0.1 ng. ml(-1)), but not on IL-6.
1 context sentence(design, population, supporting numbers)
Summary · context
In an in vitro model of fetal alveolar type II epithelial cells, we investigated the exhibition of an anti-inflammatory activity of this peptide hormone.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-1091336704
06LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Mechanism
In fetal alveolar epithelial cells, zinc amplified thymulin effects on TNF-alpha.
In plain wordsIn cells, zinc increased thymulin effects on TNF-alpha.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseTNF-alpha response with zinc
Study
n: not reported in source
fetal alveolar type II epithelial cells
Outcome group
Inflammation markers · Respiratory
Measurements
IC50
< 0.1 ng. ml(-1)
thymulin with zinc
Source sentences
Summary
This cation (100 microM) amplified the effect of thymulin on IL-1 beta and TNF-alpha (IC(50) < 0.1 ng. ml(-1)), but not on IL-6.
1 context sentence(design, population, supporting numbers)
Summary · context
In an in vitro model of fetal alveolar type II epithelial cells, we investigated the exhibition of an anti-inflammatory activity of this peptide hormone.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-1091336705
07LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Mechanism
In fetal alveolar epithelial cells, zinc did not amplify thymulin effects on IL-6.
In plain wordsIn cells, zinc did not increase thymulin effects on IL-6.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeIL-6 response with zinc
Study
n: not reported in source
fetal alveolar type II epithelial cells
Outcome group
Inflammation markers · Respiratory
Source sentences
Summary
This cation (100 microM) amplified the effect of thymulin on IL-1 beta and TNF-alpha (IC(50) < 0.1 ng. ml(-1)), but not on IL-6.
1 context sentence(design, population, supporting numbers)
Summary · context
In an in vitro model of fetal alveolar type II epithelial cells, we investigated the exhibition of an anti-inflammatory activity of this peptide hormone.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-1091336706

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 2
21 Oct 2026, 13:55 UTC
Study data updated · source update from Europe PMC
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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