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Study · Non-randomized trial · n = 8 · 2000

4 results

Growth hormone responses during strenuous exercise: the role of GH-releasing hormone and GH-releasing peptide-2.

Maas HCM, de Vries WR, Maitimu I, Bol E, Bowers CY, Koppeschaar HP

Medicine and science in sports and exercise1 Jul 2000Cited by 5 (Europe PMC)

PMID10912886 (opens in a new tab)DOI10.1097/00005768-200007000-00007 (opens in a new tab)PepBankPUB-10912886
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy men, exercise plus GHRP‑2 produced a larger GH area under the curve over 120 min than exercise alone.

    In plain wordsIn healthy men, GHRP‑2 during exercise gave a larger GH release than exercise alone.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH AUC with exercise plus GHRP-2 versus exercise alone
    Study

    n = 8

    Comparator
    Exercise alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    200 microg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Significant differences (P < 0.003) were observed between the AUCs after administration of EX alone (mean +/- SEM): 2,324 +/- 312 microg x L(-1) 120 min, after EX plus GHRH: 6,952 +/- 1,083, after EX plus GHRP-2: 14,674 +/- 2,210, and after the combination EX plus GHRH plus GHRP-2: 17,673 +/- 1,670.
    1 context sentence
    Summary · context
    Eight healthy male subjects (ages: 22 +/- 1.2 (mean +/- SD) yr, BMI: 22.5 +/- 2.2 kg x m(-2)) were exposed to maximally stimulating dose of 100 microg GHRH iv, and 200 microg GHRP-2 iv, during incremental EX on a cycle ergometer to exhaustion.
  2. 02HumanNon-randomized trialEfficacy outcome

    In healthy men, exercise plus GHRH plus GHRP‑2 produced a larger GH area under the curve than exercise plus GHRH.

    In plain wordsIn healthy men, adding GHRP‑2 to GHRH during exercise gave a larger GH release than GHRH during exercise alone.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH AUC with exercise plus GHRH plus GHRP-2 versus exercise plus GHRH
    Study

    n = 8

    Comparator
    Exercise plus GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    200 microg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Significant differences (P < 0.003) were observed between the AUCs after administration of EX alone (mean +/- SEM): 2,324 +/- 312 microg x L(-1) 120 min, after EX plus GHRH: 6,952 +/- 1,083, after EX plus GHRP-2: 14,674 +/- 2,210, and after the combination EX plus GHRH plus GHRP-2: 17,673 +/- 1,670.
    1 context sentence
    Summary · context
    Eight healthy male subjects (ages: 22 +/- 1.2 (mean +/- SD) yr, BMI: 22.5 +/- 2.2 kg x m(-2)) were exposed to maximally stimulating dose of 100 microg GHRH iv, and 200 microg GHRP-2 iv, during incremental EX on a cycle ergometer to exhaustion.

Studies that did not test the peptide alone2

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

  1. 03HumanNot a test of GHRP-2 aloneNon-randomized trialMechanism

    In healthy men, GH AUCs after each combination of exercise, GHRH and GHRP‑2 did not differ significantly from the arithmetical addition of each separate stimulus.

    In plain wordsIn healthy men, the GH release from combined stimuli was about the sum of the separate stimuli.

    Peptide
    GHRP-2
    Outcome
    No significant changeInteraction of exercise, GHRH and GHRP-2 on GH AUC
    Study

    n = 8

    Comparator
    Arithmetical addition of separate stimuli
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    However, AUCs after each combination did not differ significantly from those after arithmetical addition of each separate stimulus, indicating that the mechanisms of the respective stimuli do not interact.
    1 context sentence
    Summary · context
    Eight healthy male subjects (ages: 22 +/- 1.2 (mean +/- SD) yr, BMI: 22.5 +/- 2.2 kg x m(-2)) were exposed to maximally stimulating dose of 100 microg GHRH iv, and 200 microg GHRP-2 iv, during incremental EX on a cycle ergometer to exhaustion.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  2. 04HumanNot a test of GHRP-2 aloneNon-randomized trialMechanism

    In healthy men, regression analysis of the GH response to exercise plus GHRP‑2 showed a synergistic action of GHRP‑2 on GHRH.

    In plain wordsIn healthy men during exercise, GHRP‑2 appeared to work together with GHRH to raise GH.

    Peptide
    GHRP-2
    Outcome
    IncreaseSynergy of GHRP-2 with GHRH during exercise
    Study

    n = 8

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    In the latter response, a synergistic action of GHRP-2 on GHRH could be observed.
    2 context sentences
    Summary · context
    GHRH alone and EX alone also explained about 74% of the response to the combination EX plus GHRP-2.
    Summary · context
    Eight healthy male subjects (ages: 22 +/- 1.2 (mean +/- SD) yr, BMI: 22.5 +/- 2.2 kg x m(-2)) were exposed to maximally stimulating dose of 100 microg GHRH iv, and 200 microg GHRP-2 iv, during incremental EX on a cycle ergometer to exhaustion.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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