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Study · In vitro (cells) · rat · 2000

4 results

Oxytocin depresses spontaneous gamma-aminobutyric acid-ergic inhibitory postsynaptic currents in cultured mitral cells of the rat olfactory bulb by a presynaptic mechanism.

Osako Y, Otsuka T, Taniguchi M, Oka T, Kaba H

Neuroscience letters1 Jul 2000Cited by 12 (Europe PMC)

PMID10899400 (opens in a new tab)DOI10.1016/s0304-3940(00)01235-0 (opens in a new tab)PepBankPUB-10899400
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cultured rat olfactory bulb mitral/tufted cells, oxytocin reversibly reduced the frequency of GABA(A) receptor-mediated spontaneous inhibitory postsynaptic currents.

    In plain wordsIn rat brain cells in a dish, oxytocin reduced how often inhibitory nerve signals occurred.

    Peptide
    Oxytocin
    Outcome
    DecreaseFrequency of spontaneous inhibitory postsynaptic currents
    Study

    ratn: not reported in source

    Cultured mitral/tufted cells of the olfactory bulb
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    OT reversibly reduced the frequency of sIPSCs
    1 context sentence
    Summary · context
    We examined the action of OT on gamma-aminobutyric acid(A) (GABA(A)) receptor-mediated spontaneous inhibitory postsynaptic currents (sIPSCs) in cultured mitral/tufted (M/T) cells with the use of whole-cell patch-clamp recordings.
  2. 02LabIn vitro (cells)Mechanism

    In cultured rat olfactory bulb mitral/tufted cells, oxytocin did not affect the amplitude of spontaneous inhibitory postsynaptic currents.

    In plain wordsIn rat brain cells in a dish, oxytocin did not change the size of inhibitory nerve signals.

    Peptide
    Oxytocin
    Outcome
    No significant changeAmplitude of spontaneous inhibitory postsynaptic currents
    Study

    ratn: not reported in source

    Cultured mitral/tufted cells of the olfactory bulb
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    without affecting the amplitudes.
    1 context sentence
    Summary · context
    We examined the action of OT on gamma-aminobutyric acid(A) (GABA(A)) receptor-mediated spontaneous inhibitory postsynaptic currents (sIPSCs) in cultured mitral/tufted (M/T) cells with the use of whole-cell patch-clamp recordings.
  3. 03LabIn vitro (cells)Mechanism

    In cultured rat olfactory bulb mitral/tufted cells, an oxytocin receptor antagonist blocked the effect of oxytocin on spontaneous inhibitory postsynaptic currents.

    In plain wordsIn rat brain cells in a dish, a drug that blocks oxytocin receptors stopped the effect of oxytocin on nerve signals.

    Peptide
    Oxytocin
    Outcome
    Not applicableBlockade of OT effect on sIPSCs by an OT receptor antagonist
    Study

    ratn: not reported in source

    Cultured mitral/tufted cells of the olfactory bulb
    Comparator
    OT receptor antagonist
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The effect of OT on sIPSCs was mimicked by the OT receptor agonist [Thr(4), Gly(7)]-OT in a reversible manner and blocked by the OT receptor antagonist desGly-NH(2)(9), d(CH(2))(5)-[Tyr(Me)(2), Thr(4)]-ornithine-vasotocin.
    1 context sentence
    Summary · context
    We examined the action of OT on gamma-aminobutyric acid(A) (GABA(A)) receptor-mediated spontaneous inhibitory postsynaptic currents (sIPSCs) in cultured mitral/tufted (M/T) cells with the use of whole-cell patch-clamp recordings.
  4. 04LabIn vitro (cells)Mechanism

    In cultured rat olfactory bulb mitral/tufted cells, oxytocin had no effect on membrane currents evoked by exogenous GABA.

    In plain wordsIn rat brain cells in a dish, oxytocin did not change the currents caused by added GABA.

    Peptide
    Oxytocin
    Outcome
    No significant changeMembrane currents evoked by exogenous GABA
    Study

    ratn: not reported in source

    Cultured mitral/tufted cells of the olfactory bulb
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    OT has no effect, however, on the membrane currents evoked by exogenous application of GABA.
    1 context sentence
    Summary · context
    We examined the action of OT on gamma-aminobutyric acid(A) (GABA(A)) receptor-mediated spontaneous inhibitory postsynaptic currents (sIPSCs) in cultured mitral/tufted (M/T) cells with the use of whole-cell patch-clamp recordings.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

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