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Study · Not a test of the peptide alone · 2000

2 results

Analogs of lactam derivatives of alpha-melanotropin with basic and acidic residues.

Bednarek MA, MacNeil T, Kalyani RN, Tang R, Van der Ploeg LH, Weinberg DH

Biochemical and biophysical research communications1 May 2000Cited by 29 (Europe PMC)

PMID10872798 (opens in a new tab)DOI10.1006/bbrc.2000.2589 (opens in a new tab)PepBankPUB-10872798
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

  1. 01LabNot a test of Melanotan II aloneIn vitro (cells)Activity measurement

    In lab tests, MTII analogs with Glu replacing Phe (Nal) or Trp were practically inactive at melanocortin receptors 3, 4 and 5.

    In plain wordsIn lab tests, changed forms of melanotan II with Glu in place of Phe or Trp were practically inactive at the receptors.

    Peptide
    Melanotan II
    Outcome
    Not applicableActivity of Phe/Nal or Trp to Glu analogs of MTII at melanocortin receptors
    Study

    humann: not reported in source

    human melanocortin receptors 3, 4 and 5
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Replacement of Phe (Nal) or Trp with Glu resulted in analogs of MTII and SHU9119 which were practically inactive at the receptors studied.
    1 context sentence
    Summary · context
    Analogs of MTII and SHU9119 with glutamic acid replacing one amino acid at a time were synthesized and tested for their ability to bind to and activate human melanocortin receptors 3, 4, and 5.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

  2. 02LabNot a test of Melanotan II aloneIn vitro (cells)Activity measurement

    In lab tests, MTII analogs with Glu in place of His or Arg were tolerated, which suggests that these basic residues do not contact the receptors.

    In plain wordsIn lab tests, changed forms of melanotan II with Glu in place of His or Arg still worked at the receptors.

    Peptide
    Melanotan II
    Outcome
    Not applicableTolerance of Glu in the His or Arg position of MTII analogs
    Study

    humann: not reported in source

    human melanocortin receptors 3, 4 and 5
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    The rather large (and unexpected) tolerance toward the presence of Glu in the position of His or Arg of MTII and SHU9119
    1 context sentence
    Summary · context
    Analogs of MTII and SHU9119 with glutamic acid replacing one amino acid at a time were synthesized and tested for their ability to bind to and activate human melanocortin receptors 3, 4, and 5.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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