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Study · In vitro (cells) · pig · 2000

2 results

Differential regulation of pig theca cell steroidogenesis by LH, insulin-like growth factor I and granulosa cells in serum-free culture.

Shores EM, Picton HM, Hunter MG

Journal of reproduction and fertility1 Mar 2000Cited by 20 (Europe PMC)

PMID10864784 (opens in a new tab)DOI10.1530/jrf.0.1180211 (opens in a new tab)PepBankPUB-10864784
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In serum-free cultures of pig theca cells, long R3 IGF-I at 10 ng/ml increased oestradiol production.

    In plain wordsIn lab tests on pig ovarian cells, an IGF-I analogue raised oestradiol production.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseOestradiol production by theca cells
    Study

    pign: not reported in source

    Primary pig theca cells in serum-free culture
    Comparator
    Untreated control cultures
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 ng/mlAs given in this study (pig).

    Source sentences

    Summary
    Oestradiol production was increased by 10 ng IGF-I ml(-1) (P < 0.001)
    1 context sentence
    Summary · context
    Theca cells were isolated from antral follicles 6-9 mm in diameter and the effects of plating density (50-150x10(3) viable cells per well), LH (0.01-1.0 ng ml(-1)), Long R3 insulin-like growth factor I (IGF-I) (10, 100 ng ml(-1)) and insulin (1, 10 ng ml(-1)) on the number of cells and steroidogenesis were examined.
  2. 02LabIn vitro (cells)Efficacy outcome

    In serum-free cultures of pig theca cells, long R3 IGF-I increased androstenedione production, but only at 100 ng/ml.

    In plain wordsIn lab tests on pig ovarian cells, an IGF-I analogue raised androstenedione production, but only at the higher dose.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseAndrostenedione production by theca cells
    Study

    pign: not reported in source

    Primary pig theca cells in serum-free culture
    Comparator
    Untreated control cultures
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 ng/mlAs given in this study (pig).

    Source sentences

    Summary
    Oestradiol production was increased by 10 ng IGF-I ml(-1) (P < 0.001) but androstenedione required 100 ng ml(-1) (P < 0.001).
    1 context sentence
    Summary · context
    Theca cells were isolated from antral follicles 6-9 mm in diameter and the effects of plating density (50-150x10(3) viable cells per well), LH (0.01-1.0 ng ml(-1)), Long R3 insulin-like growth factor I (IGF-I) (10, 100 ng ml(-1)) and insulin (1, 10 ng ml(-1)) on the number of cells and steroidogenesis were examined.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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