Skip to content

Study · In vitro (cells) · 2000

2 results

Differential effects of IGF-binding proteins, IGFBP-3 and IGFBP-5, on IGF-I action and binding to cell membranes of immortalized human chondrocytes.

Matsumoto T, Tsurumoto T, Goldring MB, Shindo H

The Journal of endocrinology1 Jul 2000Cited by 28 (Europe PMC)

PMID10856880 (opens in a new tab)DOI10.1677/joe.0.1660029 (opens in a new tab)PepBankPUB-10856880
Source linkPubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    Des(1‑3)IGF-I stimulated C-28/I2 chondrocyte proliferation in a dose-dependent manner in serum-free medium.

    In plain wordsIn cells, des(1‑3)IGF-I increased cartilage cell proliferation as dose increased.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseCell proliferation
    Study

    humann: not reported in source

    C-28/I2 immortalized chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment of the C-28/I2 cells with IGF-I or des(1-3)IGF-I in serum-free medium stimulated cell proliferation in a dose-dependent manner.
    1 context sentence
    Summary · context
    The object of this study was to investigate the effects of IGFBPs on IGF-I action and on binding of IGF-I to cells using a reproducible immortalized human chondrocyte culture model.
  2. 02LabIn vitro (cells)Activity measurement

    Des(1‑3)IGF-I stimulated chondrocyte proliferation more potently than IGF-I.

    In plain wordsIn cells, des(1‑3)IGF-I stimulated cartilage cell proliferation more potently than IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseProliferative potency
    Study

    humann: not reported in source

    C-28/I2 immortalized chondrocytes
    Comparator
    IGF-I
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, the effect of des(1-3)IGF-I was more potent, thereby suggesting that endogenously produced IGFBPs inhibited IGF action.
    2 context sentences
    Summary · context
    Treatment of the C-28/I2 cells with IGF-I or des(1-3)IGF-I in serum-free medium stimulated cell proliferation in a dose-dependent manner.
    Summary · context
    The object of this study was to investigate the effects of IGFBPs on IGF-I action and on binding of IGF-I to cells using a reproducible immortalized human chondrocyte culture model.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.