Skip to content

Study · Animal study (in vivo) · rat · 2000

2 results

Novel studies on influence of gonadotropins and insulin-like growth factor-I on growth of cumulus oophorus in the rat.

Khamsi F, Roberge S

Endocrine1 Feb 2000Cited by 1 (Europe PMC)

PMID10855689 (opens in a new tab)DOI10.1385/endo:12:1:41 (opens in a new tab)PepBankPUB-10855689
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In immature rats, in vivo LR3-IGF-I treatment had no effect on cumulus cell replication.

    In plain wordsIn immature rats, an IGF-I analogue had no effect on the replication of cumulus cells from the ovary.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeCumulus cell replication after in vivo LR3-IGF-I
    Study

    ratn: not reported in source

    cumulus cells from immature rats treated in vivo
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vivo treatment with LR3-IGF-I had no effect on CC replication.
    2 context sentences
    Summary · context
    Immature rats received in vivo treatments of either saline, equine chorionic gonadotropin (eCG) with high FSH activity, an IGF-I analog (LR3-IGF-I) with poor binding to IGF-I binding proteins, or a combination of both hormones.
    Summary · context
    CCs proliferation were assessed by measurement of 3H-thymidine incorporation.

Studies that did not test the peptide alone1

In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 LR3.

  1. 02AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Efficacy outcome

    In immature rats, in vivo eCG plus LR3-IGF-I was the only in vivo treatment that gave higher cumulus cell proliferation with IGF-I in vitro.

    In plain wordsIn immature rats, only the combined eCG and IGF-I analogue treatment led to higher cumulus cell growth when cells were later exposed to IGF-I.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseCumulus cell proliferation after in vivo eCG plus LR3-IGF-I, with IGF-I in vitro
    Study

    ratn: not reported in source

    cumulus cells from immature rats treated in vivo
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    The combination of eCG and LR3-IGF-I was the only in vivo treatment to stimulate higher CC proliferation with IGF-I in vitro treatment.
    2 context sentences
    Summary · context
    Immature rats received in vivo treatments of either saline, equine chorionic gonadotropin (eCG) with high FSH activity, an IGF-I analog (LR3-IGF-I) with poor binding to IGF-I binding proteins, or a combination of both hormones.
    Summary · context
    CCs proliferation were assessed by measurement of 3H-thymidine incorporation.

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.