Male hypogonadism caused by homozygous deletion of exon 10 of the luteinizing hormone (LH) receptor: differential action of human chorionic gonadotropin and LH.

Gromoll J, Eiholzer U, Nieschlag E, Simoni M

The Journal of clinical endocrinology and metabolism1 Jun 2000Cited by 103 (Europe PMC)

PMID10852464DOI10.1210/jcem.85.6.6636PepBankPUB-10852464

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

01HumanCase report or seriesEfficacy outcome
In a patient with LH receptor exon deletion, an hCG stimulation test induced testosterone biosynthesis and secretion within the normal range.
In plain wordsIn a patient with an LH receptor deletion, hCG stimulation induced testosterone production and release within the normal range.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseTestosterone biosynthesis and secretion
Study
n = 1
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
A hCG stimulation test induced testosterone biosynthesis and secretion within the normal range.
1 context sentence(design, population, supporting numbers)
Summary · context
We report the unique case of a patient with Leydig cell hypoplasia (LCH) type II caused by a genomic deletion resulting in the complete absence of exon 10 of the LH receptor (LHR).
Report a problemFND-1085246401
02HumanCase report or seriesEfficacy outcome
In a patient with LH receptor exon deletion, continued hCG treatment increased testicular volume.
In plain wordsIn a patient with an LH receptor deletion, continued hCG treatment increased testicular volume.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseTesticular volume
Study
n = 1
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 16 weeksAs given in this study (human).
Source sentences
Summary
Subsequently, hCG treatment was continued, resulting in an increase in testicular volume and the appearance of spermatozoa in the ejaculate after 16 weeks of treatment (5.3 million/mL).
1 context sentence(design, population, supporting numbers)
Summary · context
We report the unique case of a patient with Leydig cell hypoplasia (LCH) type II caused by a genomic deletion resulting in the complete absence of exon 10 of the LH receptor (LHR).
Report a problemFND-1085246402
03HumanCase report or seriesEfficacy outcome
In a patient with LH receptor exon deletion, hCG treatment produced ejaculated sperm after 16 weeks, at 5.3 million/mL.
In plain wordsIn a patient with an LH receptor deletion, hCG treatment produced ejaculated sperm after 16 weeks.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseSperm appearance and concentration
Study
n = 1
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 16 weeksAs given in this study (human).
Measurements
sperm concentration
5.3 million/mL
after 16 weeks of hCG treatment
Source sentences
Summary
Subsequently, hCG treatment was continued, resulting in an increase in testicular volume and the appearance of spermatozoa in the ejaculate after 16 weeks of treatment (5.3 million/mL).
1 context sentence(design, population, supporting numbers)
Summary · context
We report the unique case of a patient with Leydig cell hypoplasia (LCH) type II caused by a genomic deletion resulting in the complete absence of exon 10 of the LH receptor (LHR).
Report a problemFND-1085246403

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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