Central oxytocin modulates exercise-induced tachycardia.

Braga DC, Mori E, Higa KT, Morris M, Michelini LC

American journal of physiology. Regulatory, integrative and comparative physiology1 Jun 2000Cited by 60 (Europe PMC)

PMID10848513DOI10.1152/ajpregu.2000.278.6.r1474PepBankPUB-10848513

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In sedentary and trained rats, oxytocin given into the NTS/DMV blunted the tachycardic response to exercise.
In plain wordsIn rats, oxytocin placed in this brain area reduced the heart rate rise during exercise, compared with saline.
Peptide
Oxytocin
Outcome
DecreaseExercise-induced tachycardia after NTS/DMV OT
Study
ratn: not reported in source
Trained and sedentary rats
Comparator
Vehicle (saline)
Outcome group
Heart function · Cardiovascular
Studied dose
20 pmol/200 nl · microinjection into the NTS/DMVAs given in this study (rat).
Source sentences
Summary
Pretreatment with exogenous OT in the NTS/DMV blunted the tachycardic response both in S and T rats without changing the MAP response.
2 context sentences(design, population, supporting numbers)
Summary · context
Arterial pressure (AP) and HR responses to dynamic exercise (0.4-1.4 km/h) were compared in S and T pretreated with vehicle (saline), oxytocin (OT; 20 pmol/200 nl) or OT-receptor antagonist (OT(ant); 20 pmol/200 nl) into the NTS/DMV.
Summary · context
In the present study, we investigated whether oxytocinergic projections to the nucleus of the solitary tract (NTS)-dorsal motor nucleus of the vagus (DMV) complex (NTS/DMV) are involved in the differential heart rate (HR) response to exercise in T and S rats.
Report a problemFND-1084851306
02AnimalAnimal study (in vivo)Efficacy outcome
In sedentary and trained rats, oxytocin given into the NTS/DMV did not change the mean arterial pressure response to exercise.
In plain wordsIn rats, oxytocin placed in this brain area did not change the blood pressure response to exercise.
Peptide
Oxytocin
Outcome
No significant changeMean arterial pressure response to exercise after NTS/DMV OT
Study
ratn: not reported in source
Trained and sedentary rats
Comparator
Vehicle (saline)
Outcome group
Blood pressure · Cardiovascular
Studied dose
20 pmol/200 nl · microinjection into the NTS/DMVAs given in this study (rat).
Source sentences
Summary
without changing the MAP response.
2 context sentences(design, population, supporting numbers)
Summary · context
Arterial pressure (AP) and HR responses to dynamic exercise (0.4-1.4 km/h) were compared in S and T pretreated with vehicle (saline), oxytocin (OT; 20 pmol/200 nl) or OT-receptor antagonist (OT(ant); 20 pmol/200 nl) into the NTS/DMV.
Summary · context
In the present study, we investigated whether oxytocinergic projections to the nucleus of the solitary tract (NTS)-dorsal motor nucleus of the vagus (DMV) complex (NTS/DMV) are involved in the differential heart rate (HR) response to exercise in T and S rats.
Report a problemFND-1084851307
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, oxytocin given into the fourth cerebral ventricle had no effect on the cardiovascular response to dynamic exercise.
In plain wordsIn rats, oxytocin placed in the fourth brain ventricle had no effect on heart and blood pressure responses to exercise.
Peptide
Oxytocin
Outcome
No significant changeCardiovascular response to exercise after fourth ventricle OT
Study
ratn: not reported in source
Trained and sedentary rats
Comparator
Vehicle (saline)
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated · fourth cerebral ventricleAs given in this study (rat).
Source sentences
Summary
Administration of OT-receptor antagonist or OT into the fourth cerebral ventricle had no effect on the cardiovascular response to dynamic exercise.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we investigated whether oxytocinergic projections to the nucleus of the solitary tract (NTS)-dorsal motor nucleus of the vagus (DMV) complex (NTS/DMV) are involved in the differential heart rate (HR) response to exercise in T and S rats.
Report a problemFND-1084851308

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

04AnimalEndogenous levelAnimal study (in vivo)Other
In trained rats, exercise increased the body's own oxytocin content in dorsal and ventral brain stem and spinal cord; no such increase was reported in sedentary rats.
In plain wordsIn trained rats, exercise raised the body's own oxytocin in parts of the brain stem and spinal cord.
Peptide
Oxytocin
Outcome
IncreaseBrain and spinal cord OT content after exercise
Study
ratn: not reported in source
Trained and sedentary rats
Outcome group
Hormone levels · Endocrine and hormones
Measurements
OT content increase
4.5 fold
dorsal brain stem, trained rats
OT content increase
2.7 fold
ventral brain stem, trained rats
OT content increase
3.4 fold
spinal cord, trained rats
Source sentences
Summary
Exercise increased OT content in dorsal (4.5-fold) and ventral brain stem (2.7-fold) and spinal cord (3.4-fold) only in T rats.
1 context sentence(design, population, supporting numbers)
Summary · context
OT content in specific brain regions and plasma were measured in separate S and T groups at rest and immediately after exercise.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1084851301
05AnimalEndogenous levelAnimal study (in vivo)Other
In trained rats, plasma oxytocin levels were reduced immediately after exercise.
In plain wordsIn trained rats, the body's own oxytocin in blood fell right after exercise.
Peptide
Oxytocin
Outcome
DecreasePlasma OT after exercise
Study
ratn: not reported in source
Trained and sedentary rats
Outcome group
Hormone levels · Endocrine and hormones
Source sentences
Summary
plasma levels of T rats were reduced immediately after exercise.
1 context sentence(design, population, supporting numbers)
Summary · context
OT content in specific brain regions and plasma were measured in separate S and T groups at rest and immediately after exercise.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1084851302
06AnimalEndogenous levelAnimal study (in vivo)Other
In rats, exercise did not significantly change oxytocin content in neurosecretory regions, the median eminence or the posterior pituitary.
In plain wordsIn rats, exercise did not change the body's own oxytocin in these hormone-producing brain regions.
Peptide
Oxytocin
Outcome
No significant changeOT content in neurosecretory regions, median eminence and posterior pituitary
Study
ratn: not reported in source
Trained and sedentary rats
Outcome group
Hormone levels · Endocrine and hormones
Source sentences
Summary
No significant changes were observed in neurosecretory regions or medial eminence and posterior pituitary
1 context sentence(design, population, supporting numbers)
Summary · context
OT content in specific brain regions and plasma were measured in separate S and T groups at rest and immediately after exercise.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1084851303

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

07AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome
In rats, an oxytocin receptor antagonist in the NTS/DMV did not change basal mean arterial pressure and heart rate or the pressure response to exercise.
In plain wordsIn rats, blocking oxytocin receptors in this brain area did not change resting blood pressure or heart rate.
Peptide
Oxytocin
Outcome
No significant changeBasal blood pressure, heart rate and pressure response to exercise with NTS/DMV OT receptor blockade
Study
ratn: not reported in source
Trained and sedentary rats
Comparator
Vehicle (saline)
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
Blockade of NTS/DMV OT receptors did not change basal mean AP (MAP) and HR or the MAP response to exercise.
2 context sentences(design, population, supporting numbers)
Summary · context
Arterial pressure (AP) and HR responses to dynamic exercise (0.4-1.4 km/h) were compared in S and T pretreated with vehicle (saline), oxytocin (OT; 20 pmol/200 nl) or OT-receptor antagonist (OT(ant); 20 pmol/200 nl) into the NTS/DMV.
Summary · context
In the present study, we investigated whether oxytocinergic projections to the nucleus of the solitary tract (NTS)-dorsal motor nucleus of the vagus (DMV) complex (NTS/DMV) are involved in the differential heart rate (HR) response to exercise in T and S rats.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1084851304
08AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome
In trained rats, an oxytocin receptor antagonist in the NTS/DMV potentiated exercise-induced tachycardia, but not in sedentary rats.
In plain wordsIn trained rats, blocking oxytocin receptors in this brain area increased the heart rate rise during exercise.
Peptide
Oxytocin
Outcome
IncreaseExercise-induced tachycardia with NTS/DMV OT receptor blockade
Study
ratn: not reported in source
Trained and sedentary rats
Comparator
Vehicle (saline)
Outcome group
Heart function · Cardiovascular
Measurements
Exercise tachycardia increase
26%
trained rats, average
Source sentences
Summary
However, OT(ant) potentiated exercise-induced tachycardia (average increase of 26%) only in the T group.
2 context sentences(design, population, supporting numbers)
Summary · context
Arterial pressure (AP) and HR responses to dynamic exercise (0.4-1.4 km/h) were compared in S and T pretreated with vehicle (saline), oxytocin (OT; 20 pmol/200 nl) or OT-receptor antagonist (OT(ant); 20 pmol/200 nl) into the NTS/DMV.
Summary · context
In the present study, we investigated whether oxytocinergic projections to the nucleus of the solitary tract (NTS)-dorsal motor nucleus of the vagus (DMV) complex (NTS/DMV) are involved in the differential heart rate (HR) response to exercise in T and S rats.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1084851305
09AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome
In rats, an oxytocin receptor antagonist given into the fourth cerebral ventricle had no effect on the cardiovascular response to dynamic exercise.
In plain wordsIn rats, blocking oxytocin receptors in the fourth brain ventricle had no effect on heart and blood pressure responses to exercise.
Peptide
Oxytocin
Outcome
No significant changeCardiovascular response to exercise after fourth ventricle OT receptor antagonist
Study
ratn: not reported in source
Trained and sedentary rats
Comparator
Vehicle (saline)
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
Administration of OT-receptor antagonist or OT into the fourth cerebral ventricle had no effect on the cardiovascular response to dynamic exercise.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we investigated whether oxytocinergic projections to the nucleus of the solitary tract (NTS)-dorsal motor nucleus of the vagus (DMV) complex (NTS/DMV) are involved in the differential heart rate (HR) response to exercise in T and S rats.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1084851309

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

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