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Study · In vitro (cell-free) · 2000

7 results

Inhibitory effect of a brain derived peptide preparation on the Ca++-dependent protease, calpain.

Wronski R, Tompa P, Hutter-Paier B, Crailsheim K, Friedrich P, Windisch M

Journal of neural transmission (Vienna, Austria : 1996)1 Jan 2000Cited by 20 (Europe PMC)

PMID10847556 (opens in a new tab)DOI10.1007/s007020050013 (opens in a new tab)PepBankPUB-10847556
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Activity measurement

    In cell-free assays, Cerebrolysin inhibited mu-calpain.

    In plain wordsIn lab tests, Cerebrolysin inhibited mu-calpain.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseMu-calpain activity
    Study

    n: not reported in source

    Protease assays
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The caseinolytic assay showed that the drug inhibits both mu- and m-calpain and to a significantly lower extent also trypsin [Enzyme Commission (EC) number: 3.4.21.1] and papain [Enzyme commission (EC) number: 3.4.22.6].
    1 context sentence
    Summary · context
    In this work several in vitro methods have been applied to investigate the interaction between Cerebrolysin and calpain [Enzyme Commission (EC) number: 3.4.22.17].
  2. 02LabIn vitro (cell-free)Activity measurement

    In cell-free assays, Cerebrolysin inhibited m-calpain.

    In plain wordsIn lab tests, Cerebrolysin inhibited m-calpain.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseM-calpain activity
    Study

    n: not reported in source

    Protease assays
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The caseinolytic assay showed that the drug inhibits both mu- and m-calpain and to a significantly lower extent also trypsin [Enzyme Commission (EC) number: 3.4.21.1] and papain [Enzyme commission (EC) number: 3.4.22.6].
    1 context sentence
    Summary · context
    In this work several in vitro methods have been applied to investigate the interaction between Cerebrolysin and calpain [Enzyme Commission (EC) number: 3.4.22.17].
  3. 03LabIn vitro (cell-free)Activity measurement

    In cell-free assays, Cerebrolysin inhibited trypsin less than calpain.

    In plain wordsIn lab tests, Cerebrolysin inhibited trypsin less than calpain.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseTrypsin activity
    Study

    n: not reported in source

    Protease assays
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The caseinolytic assay showed that the drug inhibits both mu- and m-calpain and to a significantly lower extent also trypsin [Enzyme Commission (EC) number: 3.4.21.1] and papain [Enzyme commission (EC) number: 3.4.22.6].
    1 context sentence
    Summary · context
    In this work several in vitro methods have been applied to investigate the interaction between Cerebrolysin and calpain [Enzyme Commission (EC) number: 3.4.22.17].
  4. 04LabIn vitro (cell-free)Activity measurement

    In cell-free assays, Cerebrolysin inhibited papain less than calpain.

    In plain wordsIn lab tests, Cerebrolysin inhibited papain less than calpain.

    Peptide
    Cerebrolysin
    Outcome
    DecreasePapain activity
    Study

    n: not reported in source

    Protease assays
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The caseinolytic assay showed that the drug inhibits both mu- and m-calpain and to a significantly lower extent also trypsin [Enzyme Commission (EC) number: 3.4.21.1] and papain [Enzyme commission (EC) number: 3.4.22.6].
    1 context sentence
    Summary · context
    In this work several in vitro methods have been applied to investigate the interaction between Cerebrolysin and calpain [Enzyme Commission (EC) number: 3.4.22.17].
  5. 05LabIn vitro (cell-free)Mechanism

    In dialysis experiments, Cerebrolysin-mediated calpain inhibition was reversible.

    In plain wordsIn lab tests, Cerebrolysin's calpain inhibition was reversible.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableReversibility of calpain inhibition
    Study

    n: not reported in source

    Protease assays
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Dialysis experiments revealed Cerebrolysin mediated calpain inhibition to be reversible.
    1 context sentence
    Summary · context
    In this work several in vitro methods have been applied to investigate the interaction between Cerebrolysin and calpain [Enzyme Commission (EC) number: 3.4.22.17].
  6. 06LabIn vitro (cell-free)Mechanism

    In kinetic assays, Cerebrolysin showed non-competitive or tight-binding competitive inhibition of calpain.

    In plain wordsIn lab tests, Cerebrolysin showed non-competitive or tight-binding competitive calpain inhibition.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableCalpain inhibition mode
    Study

    n: not reported in source

    Protease assays
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kinetic analysis exhibited a non-competitive, or tight-binding competitive, mode of inhibition.
    1 context sentence
    Summary · context
    In this work several in vitro methods have been applied to investigate the interaction between Cerebrolysin and calpain [Enzyme Commission (EC) number: 3.4.22.17].
  7. 07LabIn vitro (cell-free)Mechanism

    In cell-free assays, Cerebrolysin competitively inhibited trypsin.

    In plain wordsIn lab tests, Cerebrolysin competitively inhibited trypsin.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableTrypsin inhibition mode
    Study

    n: not reported in source

    Protease assays
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The clearly competitive inhibition of trypsin by the drug indicates distinct mechanisms and active components against different proteases.
    1 context sentence
    Summary · context
    In this work several in vitro methods have been applied to investigate the interaction between Cerebrolysin and calpain [Enzyme Commission (EC) number: 3.4.22.17].

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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