The variability of basal action potential firing is positively correlated with bursting in hypothalamic oxytocin neurones.

Brown D, Fontanaud P, Moos FC

Journal of neuroendocrinology1 Jun 2000Cited by 16 (Europe PMC)

PMID10844579DOI10.1046/j.1365-2826.2000.00478.xPepBankPUB-10844579

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone11

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

01AnimalNot a test of Oxytocin aloneOther designMechanism
In hypothalamic oxytocin neurones under control conditions, mean basal activity and variability of firing increased just before bursts.
In plain wordsIn recordings of oxytocin-producing brain cells, firing became higher and more variable just before bursts.
Peptide
Oxytocin
Outcome
IncreaseBasal activity and variability of firing before bursts
Study
n: not reported in source
Outcome group
Brain and neuronal activity · Endocrine and hormones
Source sentences
Summary
During control conditions, mean basal activity and variability of firing increased just before bursts.
1 context sentence(design, population, supporting numbers)
Summary · context
The relationship between the strength of the bursting activity (as quantified by burst amplitude and interburst interval) and the characteristics of the interburst basal activity were assessed.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1084457901
02AnimalNot a test of Oxytocin aloneOther designMechanism
In oxytocin neurones under conditions that facilitate bursting, burst amplitude increased.
In plain wordsIn recordings of oxytocin-producing brain cells, bursts became larger when bursting was facilitated.
Peptide
Oxytocin
Outcome
IncreaseBurst amplitude under burst facilitation
Study
n: not reported in source
Outcome group
Brain and neuronal activity · Endocrine and hormones
Source sentences
Summary
During experimental conditions leading to burst facilitation, burst amplitude increased and interburst interval decreased while a sustained increase in mean firing rate occurred.
1 context sentence(design, population, supporting numbers)
Summary · context
The relationship between the strength of the bursting activity (as quantified by burst amplitude and interburst interval) and the characteristics of the interburst basal activity were assessed.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1084457902
03AnimalNot a test of Oxytocin aloneOther designMechanism
In oxytocin neurones under conditions that facilitate bursting, the interburst interval decreased.
In plain wordsIn recordings of oxytocin-producing brain cells, the pause between bursts became shorter when bursting was facilitated.
Peptide
Oxytocin
Outcome
DecreaseInterburst interval under burst facilitation
Study
n: not reported in source
Outcome group
Brain and neuronal activity · Endocrine and hormones
Source sentences
Summary
During experimental conditions leading to burst facilitation, burst amplitude increased and interburst interval decreased while a sustained increase in mean firing rate occurred.
1 context sentence(design, population, supporting numbers)
Summary · context
The relationship between the strength of the bursting activity (as quantified by burst amplitude and interburst interval) and the characteristics of the interburst basal activity were assessed.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1084457903
04AnimalNot a test of Oxytocin aloneOther designMechanism
In oxytocin neurones under conditions that facilitate bursting, mean firing rate showed a sustained increase.
In plain wordsIn recordings of oxytocin-producing brain cells, the average firing rate stayed higher when bursting was facilitated.
Peptide
Oxytocin
Outcome
IncreaseMean firing rate under burst facilitation
Study
n: not reported in source
Outcome group
Brain and neuronal activity · Endocrine and hormones
Source sentences
Summary
During experimental conditions leading to burst facilitation, burst amplitude increased and interburst interval decreased while a sustained increase in mean firing rate occurred.
1 context sentence(design, population, supporting numbers)
Summary · context
The relationship between the strength of the bursting activity (as quantified by burst amplitude and interburst interval) and the characteristics of the interburst basal activity were assessed.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1084457904
05AnimalNot a test of Oxytocin aloneOther designMechanism
In oxytocin neurones under burst facilitation, variability of firing and spike clustering increased more than expected from the rise in basal activity.
In plain wordsIn recordings of oxytocin-producing brain cells, firing became more clustered than the rise in activity alone would explain.
Peptide
Oxytocin
Outcome
IncreaseVariability of firing under burst facilitation
Study
n: not reported in source
Outcome group
Brain and neuronal activity · Endocrine and hormones
Source sentences
Summary
Variability of firing (measured by both the standard deviation of firing rate, and the index of dispersion which corrected this standard deviation for differences in mean firing rate), increased demonstrating an increase in spike clustering greater than expected as a result of increased basal activity.
1 context sentence(design, population, supporting numbers)
Summary · context
The relationship between the strength of the bursting activity (as quantified by burst amplitude and interburst interval) and the characteristics of the interburst basal activity were assessed.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1084457905
06AnimalNot a test of Oxytocin aloneOther designMechanism
In oxytocin neurones, when bursting was restrained, mean basal activity increased substantially.
In plain wordsIn recordings of oxytocin-producing brain cells, average background firing rose a lot when bursting was held back.
Peptide
Oxytocin
Outcome
IncreaseMean basal activity when bursting was restrained
Study
n: not reported in source
Outcome group
Brain and neuronal activity · Endocrine and hormones
Source sentences
Summary
When bursting was restrained (i.e. interburst interval increased), mean basal activity increased substantially, but index of dispersion decreased.
1 context sentence(design, population, supporting numbers)
Summary · context
The relationship between the strength of the bursting activity (as quantified by burst amplitude and interburst interval) and the characteristics of the interburst basal activity were assessed.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1084457906
07AnimalNot a test of Oxytocin aloneOther designMechanism
In oxytocin neurones, when bursting was restrained, the index of dispersion of firing decreased.
In plain wordsIn recordings of oxytocin-producing brain cells, firing became less clustered when bursting was held back.
Peptide
Oxytocin
Outcome
DecreaseIndex of dispersion when bursting was restrained
Study
n: not reported in source
Outcome group
Brain and neuronal activity · Endocrine and hormones
Source sentences
Summary
When bursting was restrained (i.e. interburst interval increased), mean basal activity increased substantially, but index of dispersion decreased.
1 context sentence(design, population, supporting numbers)
Summary · context
The relationship between the strength of the bursting activity (as quantified by burst amplitude and interburst interval) and the characteristics of the interburst basal activity were assessed.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1084457907
08AnimalNot a test of Oxytocin aloneOther designMechanism
In oxytocin neurones, the interspike interval distribution narrowed, which indicates increased regularity of firing.
In plain wordsIn recordings of oxytocin-producing brain cells, firing became more regular when bursting was restrained.
Peptide
Oxytocin
Outcome
IncreaseRegularity of firing (interspike interval distribution)
Study
n: not reported in source
Outcome group
Brain and neuronal activity · Endocrine and hormones
Source sentences
Summary
A narrowing of the interspike interval distribution occurred, indicating increased regularity of firing.
1 context sentence(design, population, supporting numbers)
Summary · context
The relationship between the strength of the bursting activity (as quantified by burst amplitude and interburst interval) and the characteristics of the interburst basal activity were assessed.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1084457908
09AnimalNot a test of Oxytocin aloneOther designMechanism
In oxytocin neurones, variability of firing rate was the aspect of basal activity most strongly correlated with bursting.
In plain wordsIn recordings of oxytocin-producing brain cells, how variable the firing was linked most strongly to bursting.
Peptide
Oxytocin
Outcome
Not applicableBasal activity feature most correlated with bursting
Study
n: not reported in source
Outcome group
Brain and neuronal activity · Endocrine and hormones
Source sentences
Summary
The aspect of basal activity most strongly correlated with bursting was variability of firing rate.
1 context sentence(design, population, supporting numbers)
Summary · context
The relationship between the strength of the bursting activity (as quantified by burst amplitude and interburst interval) and the characteristics of the interburst basal activity were assessed.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1084457909
10AnimalNot a test of Oxytocin aloneOther designMechanism
In oxytocin neurones, the standard deviation of mean firing rate was the strongest correlate of burst amplitude.
In plain wordsIn recordings of oxytocin-producing brain cells, the spread of firing rate linked most strongly to burst size.
Peptide
Oxytocin
Outcome
Not applicableStrongest correlate of burst amplitude
Study
n: not reported in source
Outcome group
Brain and neuronal activity · Endocrine and hormones
Source sentences
Summary
The strongest correlate of burst amplitude was the standard deviation of mean firing rate, whereas the strongest and most consistent correlate of interburst interval was the index of dispersion.
1 context sentence(design, population, supporting numbers)
Summary · context
The relationship between the strength of the bursting activity (as quantified by burst amplitude and interburst interval) and the characteristics of the interburst basal activity were assessed.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1084457910
11AnimalNot a test of Oxytocin aloneOther designMechanism
In oxytocin neurones, the index of dispersion was the strongest and most consistent correlate of interburst interval.
In plain wordsIn recordings of oxytocin-producing brain cells, how clustered the firing was linked most strongly to the pause between bursts.
Peptide
Oxytocin
Outcome
Not applicableStrongest correlate of interburst interval
Study
n: not reported in source
Outcome group
Brain and neuronal activity · Endocrine and hormones
Source sentences
Summary
The strongest correlate of burst amplitude was the standard deviation of mean firing rate, whereas the strongest and most consistent correlate of interburst interval was the index of dispersion.
1 context sentence(design, population, supporting numbers)
Summary · context
The relationship between the strength of the bursting activity (as quantified by burst amplitude and interburst interval) and the characteristics of the interburst basal activity were assessed.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1084457911

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.