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Study · Ex vivo tissue · bovine and sheep · 2000

4 results

Response of isolated ruminant mammary arteries to the long R3 analogue of insulin-like growth factor I.

Gow IF

Experimental physiology1 May 2000Cited by 2 (Europe PMC)

PMID10825414 (opens in a new tab)DOI10.1111/j.1469-445x.2000.01973.x (opens in a new tab)PepBankPUB-10825414
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In isolated bovine mammary arteries with intact endothelium, long R3-IGF-I shifted the noradrenaline response curve to the right.

    In plain wordsIn bovine artery tissue in a dish, an IGF-I analogue shifted the noradrenaline response curve to the right.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseNoradrenaline response curve, bovine arteries with intact endothelium
    Study

    bovinen: not reported in source

    isolated mammary arteries in an organ bath
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    An analogue of insulin-like growth factor I (long R3-IGF-I) caused a rightward shift in the NA response curve in bovine vessels with intact endothelium (P < 0.02)
    1 context sentence
    Summary · context
    Isolated mammary arteries from ruminants were used in a conventional organ bath system.
  2. 02LabEx vivo tissueEfficacy outcome

    In isolated sheep mammary arteries, long R3-IGF-I shifted the noradrenaline response curve to the right.

    In plain wordsIn sheep artery tissue in a dish, an IGF-I analogue shifted the noradrenaline response curve to the right.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseNoradrenaline response curve, sheep arteries
    Study

    sheepn: not reported in source

    isolated mammary arteries in an organ bath
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    An analogue of insulin-like growth factor I (long R3-IGF-I) caused a rightward shift in the NA response curve in bovine vessels with intact endothelium (P < 0.02), and also in sheep arteries (P < 0.01).
    1 context sentence
    Summary · context
    Isolated mammary arteries from ruminants were used in a conventional organ bath system.
  3. 03LabEx vivo tissueMechanism

    In isolated bovine mammary arteries, the effect of long R3-IGF-I on the noradrenaline response was abolished when the endothelium was removed.

    In plain wordsIn bovine artery tissue in a dish, the IGF-I analogue had no effect on the noradrenaline response once the vessel lining was removed.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeEffect of long R3-IGF-I after endothelium removal
    Study

    bovinen: not reported in source

    isolated mammary arteries in an organ bath
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In bovine vessels, this effect was abolished when the endothelium was removed.
    1 context sentence
    Summary · context
    Isolated mammary arteries from ruminants were used in a conventional organ bath system.
  4. 04LabEx vivo tissueMechanism

    In isolated bovine mammary arteries, the nitric oxide synthase inhibitor L-NAME abolished the effect of long R3-IGF-I.

    In plain wordsIn bovine artery tissue in a dish, blocking nitric oxide production removed the effect of the IGF-I analogue.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeEffect of long R3-IGF-I with L-NAME
    Study

    bovinen: not reported in source

    isolated mammary arteries in an organ bath
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The effect of long R3-IGF-I in bovine vessels was abolished by N -nitro-L-arginine methyl ester (L-NAME) an inhibitor of nitric oxide synthase
    1 context sentence
    Summary · context
    Isolated mammary arteries from ruminants were used in a conventional organ bath system.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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