Skip to content

Study · Ex vivo tissue · rat · 1999

2 results

Modulation of agonist stimulated adenylyl cyclase and GTPase activity by L-pro-L-leu-glycinamide and its peptidomimetic analogue in rat striatal membranes.

Mishra RK, Makman MH, Costain WJ, Nair VD, Nair VD, Johnson RL

Neuroscience letters1 Jul 1999Cited by 18 (Europe PMC)

PMID10821635 (opens in a new tab)DOI10.1016/s0304-3940(99)00413-9 (opens in a new tab)PepBankPUB-10821635
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In rat striatal membranes, PLG inhibited dopamine-stimulated adenylyl cyclase activity in a dose-dependent manner.

    In plain wordsIn lab tests with rat brain membranes, PLG reduced dopamine-stimulated adenylyl cyclase activity.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseDopamine-stimulated adenylyl cyclase activity
    Study

    ratn: not reported in source

    rat striatal membranes
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Dopamine-stimulated adenylyl cyclase activity was inhibited by both PLG and PAOPA in a dose-dependent manner
    1 context sentence
    Summary · context
    In the present study, we examined the effect PLG and its analogue 3(R)-[(2(S)-pyrrolidylcarbonyl)amino]-2-oxo-1-pyrrolidineacetam ide (PAOPA) on dopamine-stimulated adenylyl cyclase and NPA-stimulated GTPase activity in rat striatal membranes.
  2. 02LabEx vivo tissueMechanism

    In rat striatal membranes, PLG at 1 microM significantly increased NPA-stimulated low Km GTPase activity.

    In plain wordsIn lab tests with rat brain membranes, PLG increased NPA-stimulated GTPase activity.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    IncreaseNPA-stimulated low Km GTPase activity
    Study

    ratn: not reported in source

    rat striatal membranes
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 microMAs given in this study (rat).

    Source sentences

    Summary
    whereas R(-)-propylnorapomorphine (NPA)-stimulated low Km GTPase activity was significantly increased by 1 microM PLG or 1 nM PAOPA.
    1 context sentence
    Summary · context
    In the present study, we examined the effect PLG and its analogue 3(R)-[(2(S)-pyrrolidylcarbonyl)amino]-2-oxo-1-pyrrolidineacetam ide (PAOPA) on dopamine-stimulated adenylyl cyclase and NPA-stimulated GTPase activity in rat striatal membranes.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.