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Study · Animal study (in vivo) · rat · 2000

6 results

Two peptidergic drugs increase the synaptophysin immunoreactivity in brains of 6-week-old rats.

Windholz E, Gschanes A, Windisch M, Fachbach G

The Histochemical journal1 Feb 2000Cited by 11 (Europe PMC)

PMID10816071 (opens in a new tab)DOI10.1023/a:1004053809591 (opens in a new tab)PepBankPUB-10816071
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, Cerebrolysin increased dentate gyrus synaptic density versus saline, as did its peptide preparations.

    In plain wordsIn rats, Cerebrolysin increased dentate gyrus synaptic density versus saline, as did its preparations.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSynaptic density in dentate gyrus
    Study

    ratn: not reported in source

    6-week-old rats
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.5 ml/kg, each day · postnatal days 1-7As given in this study (rat).

    Source sentences

    Summary
    An increase of synaptic density has been found in the hippocampus, the dendate gyrus and in the entorhinal cortex of 6-week-old rats after 7 days of treatment with the peptidergic drug Cerebrolysin, its peptide preparation E021 and the diluted peptide preparation E021dil.
    3 context sentences
    Summary · context
    Rats received drugs on postnatal days 1-7 (2.5 ml/kg, each day).
    Summary · context
    Controls received saline.
    Summary · context
    Slices of brain were stained immunohistochemically with anti-synaptophysin, a specific marker of presynaptic terminals.

Studies that did not test the peptide alone5

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

  1. 02AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism

    In rats, pooled peptidergic treatments increased synaptophysin-positive terminals in the entorhinal cortex compared with saline.

    In plain wordsIn rats, pooled treatments increased synaptophysin-positive terminals in the entorhinal cortex compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSynaptophysin-positive terminals in entorhinal cortex
    Study

    ratn: not reported in source

    6-week-old rats
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    A significant increase in the number of synaptophysin-immunoreactive presynaptic terminals was found in the entorhinal cortex and the hippocampal subfields CA1, CA2, CA3 stratum radiatum and CA3 stratum lucidum.
    3 context sentences
    Summary · context
    Rats received drugs on postnatal days 1-7 (2.5 ml/kg, each day).
    Summary · context
    Controls received saline.
    Summary · context
    Slices of brain were stained immunohistochemically with anti-synaptophysin, a specific marker of presynaptic terminals.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  2. 03AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism

    In rats, pooled peptidergic treatments increased synaptophysin-positive terminals in CA1 compared with saline.

    In plain wordsIn rats, pooled treatments increased synaptophysin-positive terminals in CA1 compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSynaptophysin-positive terminals in CA1
    Study

    ratn: not reported in source

    6-week-old rats
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    A significant increase in the number of synaptophysin-immunoreactive presynaptic terminals was found in the entorhinal cortex and the hippocampal subfields CA1, CA2, CA3 stratum radiatum and CA3 stratum lucidum.
    3 context sentences
    Summary · context
    Rats received drugs on postnatal days 1-7 (2.5 ml/kg, each day).
    Summary · context
    Controls received saline.
    Summary · context
    Slices of brain were stained immunohistochemically with anti-synaptophysin, a specific marker of presynaptic terminals.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  3. 04AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism

    In rats, pooled peptidergic treatments increased synaptophysin-positive terminals in CA2 compared with saline.

    In plain wordsIn rats, pooled treatments increased synaptophysin-positive terminals in CA2 compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSynaptophysin-positive terminals in CA2
    Study

    ratn: not reported in source

    6-week-old rats
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    A significant increase in the number of synaptophysin-immunoreactive presynaptic terminals was found in the entorhinal cortex and the hippocampal subfields CA1, CA2, CA3 stratum radiatum and CA3 stratum lucidum.
    3 context sentences
    Summary · context
    Rats received drugs on postnatal days 1-7 (2.5 ml/kg, each day).
    Summary · context
    Controls received saline.
    Summary · context
    Slices of brain were stained immunohistochemically with anti-synaptophysin, a specific marker of presynaptic terminals.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  4. 05AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism

    In rats, pooled peptidergic treatments increased synaptophysin-positive terminals in CA3 stratum radiatum compared with saline.

    In plain wordsIn rats, pooled treatments increased synaptophysin-positive terminals in CA3 stratum radiatum compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSynaptophysin-positive terminals in CA3 stratum radiatum
    Study

    ratn: not reported in source

    6-week-old rats
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    A significant increase in the number of synaptophysin-immunoreactive presynaptic terminals was found in the entorhinal cortex and the hippocampal subfields CA1, CA2, CA3 stratum radiatum and CA3 stratum lucidum.
    3 context sentences
    Summary · context
    Rats received drugs on postnatal days 1-7 (2.5 ml/kg, each day).
    Summary · context
    Controls received saline.
    Summary · context
    Slices of brain were stained immunohistochemically with anti-synaptophysin, a specific marker of presynaptic terminals.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  5. 06AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism

    In rats, pooled peptidergic treatments increased synaptophysin-positive terminals in CA3 stratum lucidum compared with saline.

    In plain wordsIn rats, pooled treatments increased synaptophysin-positive terminals in CA3 stratum lucidum compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSynaptophysin-positive terminals in CA3 stratum lucidum
    Study

    ratn: not reported in source

    6-week-old rats
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    A significant increase in the number of synaptophysin-immunoreactive presynaptic terminals was found in the entorhinal cortex and the hippocampal subfields CA1, CA2, CA3 stratum radiatum and CA3 stratum lucidum.
    3 context sentences
    Summary · context
    Rats received drugs on postnatal days 1-7 (2.5 ml/kg, each day).
    Summary · context
    Controls received saline.
    Summary · context
    Slices of brain were stained immunohistochemically with anti-synaptophysin, a specific marker of presynaptic terminals.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

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Terms as the source lists them.

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