The drug cerebrolysin and its peptide fraction E021 increase the abundance of the blood-brain barrier GLUT1 glucose transporter in brains of young and old rats.

Gschanes A, Boado R, Sametz W, Windisch M

The Histochemical journal1 Feb 2000Cited by 20 (Europe PMC)

PMID10816070DOI10.1023/a:1004003008683PepBankPUB-10816070

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In young rats, Cerebrolysin shortened water maze escape latencies versus saline, as did E021.
In plain wordsIn young rats, Cerebrolysin shortened escape times versus saline, as did E021.
Peptide
Cerebrolysin
Outcome
DecreaseWater maze escape latency in young rats
Study
ratn: not reported in source
2-month-old rats
Comparator
Saline
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · postnatal days 1-7As given in this study (rat).
Source sentences
Summary
All drug-treated rats, young and old, exhibit shorter escape latencies in the water maze, on all testing days (p < 0.01), indicating improved cognitive performance.
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study, we investigated the effects of Cerebrolysin and its peptide preparation E021 on spatial learning and memory, as well as on the abundance of the blood-brain barrier GLUT1 glucose transporter (GLUT1) in 2-month-old and 24-month-old rats.
Summary · context
Young rats were treated with the drugs or saline (2.5 ml/kg/day) daily on postnatal days 1-7, and old rats for 19 consecutive days.
Report a problemFND-1081607001
02AnimalAnimal study (in vivo)Efficacy outcome
In old rats, Cerebrolysin shortened water maze escape latencies versus saline, as did E021.
In plain wordsIn old rats, Cerebrolysin shortened escape times versus saline, as did E021.
Peptide
Cerebrolysin
Outcome
DecreaseWater maze escape latency in old rats
Study
ratn: not reported in source
24-month-old rats
Comparator
Saline
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · 19 consecutive daysAs given in this study (rat).
Source sentences
Summary
All drug-treated rats, young and old, exhibit shorter escape latencies in the water maze, on all testing days (p < 0.01), indicating improved cognitive performance.
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study, we investigated the effects of Cerebrolysin and its peptide preparation E021 on spatial learning and memory, as well as on the abundance of the blood-brain barrier GLUT1 glucose transporter (GLUT1) in 2-month-old and 24-month-old rats.
Summary · context
Young rats were treated with the drugs or saline (2.5 ml/kg/day) daily on postnatal days 1-7, and old rats for 19 consecutive days.
Report a problemFND-1081607002
03AnimalAnimal study (in vivo)Mechanism
In young rats, Cerebrolysin increased GLUT1 abundance versus saline, as did E021.
In plain wordsIn young rats, Cerebrolysin increased GLUT1 versus saline, as did E021.
Peptide
Cerebrolysin
Outcome
IncreaseGLUT1 abundance in young rats
Study
ratn: not reported in source
2-month-old rats
Comparator
Saline
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · postnatal days 1-7As given in this study (rat).
Source sentences
Summary
In young animals, the administration of the drugs led to an increase of the abundance of GLUT1 in all experimental groups (p < 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study, we investigated the effects of Cerebrolysin and its peptide preparation E021 on spatial learning and memory, as well as on the abundance of the blood-brain barrier GLUT1 glucose transporter (GLUT1) in 2-month-old and 24-month-old rats.
Summary · context
Young rats were treated with the drugs or saline (2.5 ml/kg/day) daily on postnatal days 1-7, and old rats for 19 consecutive days.
Report a problemFND-1081607003
04AnimalAnimal study (in vivo)Mechanism
In old rats, Cerebrolysin increased immunoreactive GLUT1 compared with saline.
In plain wordsIn old rats, Cerebrolysin increased GLUT1 compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseGLUT1 abundance in old rats
Study
ratn: not reported in source
Young and old rats
Comparator
Saline
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · 19 consecutive daysAs given in this study (rat).
Source sentences
Summary
In old rats, the treatment with Cerebrolysin, but not with E021, resulted in an increase in the immunoreactive GLUT1 (p < 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study, we investigated the effects of Cerebrolysin and its peptide preparation E021 on spatial learning and memory, as well as on the abundance of the blood-brain barrier GLUT1 glucose transporter (GLUT1) in 2-month-old and 24-month-old rats.
Summary · context
Young rats were treated with the drugs or saline (2.5 ml/kg/day) daily on postnatal days 1-7, and old rats for 19 consecutive days.
Report a problemFND-1081607004

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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