Role of vasoactive intestinal polypeptide in burn-induced oedema formation.

Lindblom L, Cassuto J, Yregård L, Tarnow P, Räntfors J, Löwhagen Hendén P

Burns : journal of the International Society for Burn Injuries1 Aug 2000Cited by 8 (Europe PMC)

PMID10812265DOI10.1016/s0305-4179(99)00177-1PepBankPUB-10812265

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In burned and non-burned rats, systemic VIP caused a significant drop in mean arterial blood pressure versus saline and versus VIP antiserum.
In plain wordsIn rats, VIP lowered blood pressure more than saline or VIP antiserum.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseMean arterial blood pressure
Study
ratn: not reported in source
Anaesthetised rats with partial- or full-thickness skin burns
Comparator
Saline and VIP antiserum
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated · systemicAs given in this study (rat).
Source sentences
Summary
Results show that systemic VIP elicited a significant drop in mean arterial blood pressure versus saline (p<0. 001) and VIP antiserum (p<0.001) both in burned and non-burned animals.
1 context sentence(design, population, supporting numbers)
Summary · context
This study investigated the role of VIP on oedema in partial- and full-thickness skin burns of anaesthetised rats in vivo by spectrophotometrical quantification of Evans blue albumin.
Report a problemFND-1081226501
02AnimalAnimal study (in vivo)Efficacy outcome
In burned and non-burned rats, VIP decreased heart rate versus saline and versus anti-VIP.
In plain wordsIn rats, VIP slowed the heart rate more than saline or anti-VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseHeart rate
Study
ratn: not reported in source
Anaesthetised rats with partial- or full-thickness skin burns
Comparator
Saline and anti-VIP
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated · systemicAs given in this study (rat).
Source sentences
Summary
VIP also decreased heart rate versus saline (p<0.05) and anti-VIP (p<0.01) in non-burned and burned animals.
1 context sentence(design, population, supporting numbers)
Summary · context
This study investigated the role of VIP on oedema in partial- and full-thickness skin burns of anaesthetised rats in vivo by spectrophotometrical quantification of Evans blue albumin.
Report a problemFND-1081226502
03AnimalAnimal study (in vivo)Efficacy outcome
In normal rat skin, VIP significantly inhibited Evans blue albumin extravasation compared with saline, and did not differ significantly from VIP antiserum.
In plain wordsIn rats, VIP reduced fluid leak into normal skin compared with saline.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseEvans blue albumin extravasation in normal skin
Study
ratn: not reported in source
Anaesthetised rats with partial- or full-thickness skin burns
Comparator
Saline
Outcome group
Vascular function · Skin and wound
Studied dose
Dose not stated · systemicAs given in this study (rat).
Source sentences
Summary
EB-albumin in normal skin was significantly inhibited by VIP as compared to saline (p<0.05), but did not differ significantly from VIP-antiserum.
1 context sentence(design, population, supporting numbers)
Summary · context
This study investigated the role of VIP on oedema in partial- and full-thickness skin burns of anaesthetised rats in vivo by spectrophotometrical quantification of Evans blue albumin.
Report a problemFND-1081226503
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with partial-thickness burns, VIP significantly reduced Evans blue albumin extravasation versus saline.
In plain wordsIn rats with skin burns, VIP reduced fluid leak into the burn compared with saline.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseEvans blue albumin extravasation in partial-thickness burns
Study
ratn: not reported in source
Anaesthetised rats with partial- or full-thickness skin burns
Comparator
Saline
Outcome group
Vascular function · Skin and wound
Studied dose
Dose not stated · systemicAs given in this study (rat).
Source sentences
Summary
Similarly, VIP significantly reduced EB-albumin extravasation versus saline treatment in partial-thickness (p<0.01) and full-thickness burns (p<0.001), while VIP-antiserum had no significant effect on skin perfusion in any of the burned groups as compared to saline treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
This study investigated the role of VIP on oedema in partial- and full-thickness skin burns of anaesthetised rats in vivo by spectrophotometrical quantification of Evans blue albumin.
Report a problemFND-1081226505
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with full-thickness burns, VIP significantly reduced Evans blue albumin extravasation versus saline.
In plain wordsIn rats with deep skin burns, VIP reduced fluid leak into the burn compared with saline.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseEvans blue albumin extravasation in full-thickness burns
Study
ratn: not reported in source
Anaesthetised rats with partial- or full-thickness skin burns
Comparator
Saline
Outcome group
Vascular function · Skin and wound
Studied dose
Dose not stated · systemicAs given in this study (rat).
Source sentences
Summary
Similarly, VIP significantly reduced EB-albumin extravasation versus saline treatment in partial-thickness (p<0.01) and full-thickness burns (p<0.001), while VIP-antiserum had no significant effect on skin perfusion in any of the burned groups as compared to saline treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
This study investigated the role of VIP on oedema in partial- and full-thickness skin burns of anaesthetised rats in vivo by spectrophotometrical quantification of Evans blue albumin.
Report a problemFND-1081226506

Studies that did not test the peptide alone2

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

06AnimalNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneAnimal study (in vivo)Efficacy outcome
In rats, VIP antiserum, which neutralizes the body's own VIP, significantly inhibited Evans blue albumin extravasation versus saline.
In plain wordsIn rats, an antibody that blocks the body's own VIP also reduced fluid leak compared with saline.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseEvans blue albumin extravasation after VIP antiserum
Study
ratn: not reported in source
Anaesthetised rats with partial- or full-thickness skin burns
Comparator
Saline
Outcome group
Vascular function · Skin and wound
Source sentences
Summary
A significant inhibition of EB-albumin extravasation versus saline was also seen following administration of VIP-antiserum (p<0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
This study investigated the role of VIP on oedema in partial- and full-thickness skin burns of anaesthetised rats in vivo by spectrophotometrical quantification of Evans blue albumin.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-1081226504
07AnimalNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneAnimal study (in vivo)Efficacy outcome
In all burned groups, VIP antiserum had no significant effect on skin perfusion compared with saline.
In plain wordsIn rats with skin burns, an antibody that blocks the body's own VIP did not change skin blood flow compared with saline.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeSkin perfusion in burned groups after VIP antiserum
Study
ratn: not reported in source
Anaesthetised rats with partial- or full-thickness skin burns
Comparator
Saline
Outcome group
Vascular function · Skin and wound
Source sentences
Summary
while VIP-antiserum had no significant effect on skin perfusion in any of the burned groups as compared to saline treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
This study investigated the role of VIP on oedema in partial- and full-thickness skin burns of anaesthetised rats in vivo by spectrophotometrical quantification of Evans blue albumin.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-1081226507

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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Role of vasoactive intestinal polypeptide in burn-induced oedema formation.

Summary

Results from this study7

Studies that did not test the peptide alone2

Version history

Subjects

Publication types

MeSH terms