Importance of vasoactive intestinal polypeptide in the regulation of burn perfusion.

Lindblom L, Cassuto J, Yregård L, Tarnow P, Räntfors J, Löwhagen Hendén P

Burns : journal of the International Society for Burn Injuries1 Aug 2000Cited by 4 (Europe PMC)

PMID10812264DOI10.1016/s0305-4179(99)00178-3PepBankPUB-10812264

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In burned and non-burned rats, systemic VIP caused a significant drop in mean arterial blood pressure versus saline and versus VIP antiserum.
In plain wordsIn rats, VIP lowered blood pressure more than saline or VIP antiserum.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseMean arterial blood pressure
Study
ratn: not reported in source
Rats with partial- or full-thickness experimental skin burns
Comparator
Saline and VIP antiserum
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated · systemicAs given in this study (rat).
Source sentences
Summary
Systemic administration of VIP elicited a significant drop in mean arterial blood pressure versus saline (p<0.001) and VIP antiserum (p<0.001) both in burned and nonburned animals.
1 context sentence(design, population, supporting numbers)
Summary · context
Its effects on postburn skin perfusion and progressive ischemia was investigated in rats exposed to partial- and full-thickness experimental skin burns.
Report a problemFND-1081226401
02AnimalAnimal study (in vivo)Efficacy outcome
In burned and non-burned rats, VIP decreased heart rate versus saline and versus anti-VIP.
In plain wordsIn rats, VIP slowed the heart rate more than saline or anti-VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseHeart rate
Study
ratn: not reported in source
Rats with partial- or full-thickness experimental skin burns
Comparator
Saline and anti-VIP
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated · systemicAs given in this study (rat).
Source sentences
Summary
VIP also decreased heart rate versus saline (p<0.05) and anti-VIP (p<0.001) in nonburned and burned animals.
1 context sentence(design, population, supporting numbers)
Summary · context
Its effects on postburn skin perfusion and progressive ischemia was investigated in rats exposed to partial- and full-thickness experimental skin burns.
Report a problemFND-1081226402
03AnimalAnimal study (in vivo)Efficacy outcome
In normal rat skin, VIP infusion significantly impaired skin perfusion compared with saline.
In plain wordsIn rats, VIP infusion reduced blood flow in normal skin compared with saline.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseSkin perfusion in normal skin
Study
ratn: not reported in source
Rats with partial- or full-thickness experimental skin burns
Comparator
Saline
Outcome group
Vascular function · Skin and wound
Studied dose
Dose not stated · systemicAs given in this study (rat).
Source sentences
Summary
Skin perfusion in normal skin was significantly impaired by VIP infusions as compared to saline (p<0.01)
1 context sentence(design, population, supporting numbers)
Summary · context
Its effects on postburn skin perfusion and progressive ischemia was investigated in rats exposed to partial- and full-thickness experimental skin burns.
Report a problemFND-1081226405
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with partial-thickness burns, VIP significantly reduced skin blood flow versus saline.
In plain wordsIn rats with skin burns, VIP reduced blood flow in the burn compared with saline.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseSkin perfusion in partial-thickness burns
Study
ratn: not reported in source
Rats with partial- or full-thickness experimental skin burns
Comparator
Saline
Outcome group
Vascular function · Skin and wound
Studied dose
Dose not stated · systemicAs given in this study (rat).
Source sentences
Summary
Similarly, VIP significantly reduced blood flow versus saline-treatment in partial-thickness (p<0.01) and full-thickness burns (p<0.05) while VIP-antiserum had no significant effect on skin perfusion in any of the burned groups as compared to saline treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Its effects on postburn skin perfusion and progressive ischemia was investigated in rats exposed to partial- and full-thickness experimental skin burns.
Report a problemFND-1081226407
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with full-thickness burns, VIP significantly reduced skin blood flow versus saline.
In plain wordsIn rats with deep skin burns, VIP reduced blood flow in the burn compared with saline.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseSkin perfusion in full-thickness burns
Study
ratn: not reported in source
Rats with partial- or full-thickness experimental skin burns
Comparator
Saline
Outcome group
Vascular function · Skin and wound
Studied dose
Dose not stated · systemicAs given in this study (rat).
Source sentences
Summary
Similarly, VIP significantly reduced blood flow versus saline-treatment in partial-thickness (p<0.01) and full-thickness burns (p<0.05) while VIP-antiserum had no significant effect on skin perfusion in any of the burned groups as compared to saline treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Its effects on postburn skin perfusion and progressive ischemia was investigated in rats exposed to partial- and full-thickness experimental skin burns.
Report a problemFND-1081226408

Studies that did not test the peptide alone4

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

06AnimalNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneAnimal study (in vivo)Efficacy outcome
In burned and non-burned rats, VIP antiserum, which neutralizes the body's own VIP, significantly increased blood pressure versus saline.
In plain wordsIn rats, an antibody that blocks the body's own VIP raised blood pressure compared with saline.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseBlood pressure after VIP antiserum
Study
ratn: not reported in source
Rats with partial- or full-thickness experimental skin burns
Comparator
Saline
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
In contrast, VIP antiserum significantly increased blood pressure (p<0. 001) and heart rate (p<0.001) versus saline in all the groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Its effects on postburn skin perfusion and progressive ischemia was investigated in rats exposed to partial- and full-thickness experimental skin burns.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-1081226403
07AnimalNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneAnimal study (in vivo)Efficacy outcome
In burned and non-burned rats, VIP antiserum, which neutralizes the body's own VIP, significantly increased heart rate versus saline.
In plain wordsIn rats, an antibody that blocks the body's own VIP raised heart rate compared with saline.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseHeart rate after VIP antiserum
Study
ratn: not reported in source
Rats with partial- or full-thickness experimental skin burns
Comparator
Saline
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
In contrast, VIP antiserum significantly increased blood pressure (p<0. 001) and heart rate (p<0.001) versus saline in all the groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Its effects on postburn skin perfusion and progressive ischemia was investigated in rats exposed to partial- and full-thickness experimental skin burns.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-1081226404
08AnimalNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneAnimal study (in vivo)Efficacy outcome
In normal rat skin, VIP antiserum did not differ significantly from saline in skin perfusion.
In plain wordsIn rats, an antibody that blocks the body's own VIP did not change blood flow in normal skin compared with saline.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeSkin perfusion in normal skin after VIP antiserum
Study
ratn: not reported in source
Rats with partial- or full-thickness experimental skin burns
Comparator
Saline
Outcome group
Vascular function · Skin and wound
Source sentences
Summary
while VIP-antiserum did not differ significantly from saline.
1 context sentence(design, population, supporting numbers)
Summary · context
Its effects on postburn skin perfusion and progressive ischemia was investigated in rats exposed to partial- and full-thickness experimental skin burns.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-1081226406
09AnimalNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneAnimal study (in vivo)Efficacy outcome
In all burned groups, VIP antiserum had no significant effect on skin perfusion compared with saline.
In plain wordsIn rats with skin burns, an antibody that blocks the body's own VIP did not change blood flow compared with saline.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeSkin perfusion in burns after VIP antiserum
Study
ratn: not reported in source
Rats with partial- or full-thickness experimental skin burns
Comparator
Saline
Outcome group
Vascular function · Skin and wound
Source sentences
Summary
while VIP-antiserum had no significant effect on skin perfusion in any of the burned groups as compared to saline treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Its effects on postburn skin perfusion and progressive ischemia was investigated in rats exposed to partial- and full-thickness experimental skin burns.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-1081226409

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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