Oxytocin and its receptors are synthesized in the rat vasculature.

Jankowski M, Wang D, Hajjar F, Mukaddam-Daher S, McCann SM, Gutkowska J

Proceedings of the National Academy of Sciences of the United States of America1 May 2000Cited by 123 (Europe PMC)

PMID10811917PMCIDPMC18583DOI10.1073/pnas.110137497PepBankPUB-10811917

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In immature female rats, diethylstilbestrol treatment significantly increased the body's own oxytocin in the vena cava.
In plain wordsIn young female rats, diethylstilbestrol raised the body's own oxytocin in the main vein.
Peptide
Oxytocin
Outcome
IncreaseOxytocin in vena cava after diethylstilbestrol
Study
ratn: not reported in source
rat vasculature
Outcome group
Endogenous peptide levels · Cardiovascular
Source sentences
Summary
In addition, we have demonstrated that diethylstilbestrol treatment of immature female rats increased OT significantly in the vena cava but not in the aorta and augmented OTR mRNA in both the aorta (4-fold) and vena cava (2-fold), implying regulation by estrogen.
1 context sentence(design, population, supporting numbers)
Summary · context
Consequently, we prepared acid extracts of the pulmonary artery and vena cava of female rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1081191707
02AnimalEndogenous levelAnimal study (in vivo)Other
In immature female rats, diethylstilbestrol treatment did not increase the body's own oxytocin in the aorta.
In plain wordsIn young female rats, diethylstilbestrol did not raise the body's own oxytocin in the main artery.
Peptide
Oxytocin
Outcome
No significant changeOxytocin in aorta after diethylstilbestrol
Study
ratn: not reported in source
rat vasculature
Outcome group
Endogenous peptide levels · Cardiovascular
Source sentences
Summary
In addition, we have demonstrated that diethylstilbestrol treatment of immature female rats increased OT significantly in the vena cava but not in the aorta and augmented OTR mRNA in both the aorta (4-fold) and vena cava (2-fold), implying regulation by estrogen.
1 context sentence(design, population, supporting numbers)
Summary · context
Consequently, we prepared acid extracts of the pulmonary artery and vena cava of female rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1081191708
03LabEndogenous levelEx vivo tissueOther
In rats, the body's own oxytocin was present in the aorta; dog and sheep aortae had equivalent concentrations.
In plain wordsIn rats, natural oxytocin was found in the wall of the main artery, at similar levels in dogs and sheep.
Peptide
Oxytocin
Outcome
Not applicableOxytocin concentration in aorta
Study
ratn: not reported in source
rat vasculature
Outcome group
Endogenous peptide levels · Cardiovascular
Measurements
Oxytocin concentration
2745 pg/mg protein
rat aorta
Source sentences
Summary
OT concentrations in dog and sheep aortae were equivalent to those of rat aorta (2745 +/- 180 pg/mg protein), indicating that it is present in the vasculature of several mammalian species.
1 context sentence(design, population, supporting numbers)
Summary · context
Consequently, we prepared acid extracts of the pulmonary artery and vena cava of female rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1081191701
04LabEndogenous levelEx vivo tissueOther
In rat aorta and vena cava extracts, HPLC showed a single peak that corresponds to the amidated oxytocin nonapeptide.
In plain wordsIn rats, tests of blood vessel extracts found the body's own oxytocin molecule in the aorta and vena cava.
Peptide
Oxytocin
Outcome
Not applicableOxytocin identity in aorta and vena cava extracts
Study
ratn: not reported in source
rat vasculature
Outcome group
Endogenous peptide levels · Cardiovascular
Source sentences
Summary
Reverse-phase HPLC of aorta and vena cava extracts revealed a single peak corresponding to the amidated OT nonapeptide.
1 context sentence(design, population, supporting numbers)
Summary · context
Consequently, we prepared acid extracts of the pulmonary artery and vena cava of female rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1081191702
05LabEndogenous levelEx vivo tissueOther
In rat vascular tissues, reverse-transcribed PCR confirmed synthesis of the body's own oxytocin.
In plain wordsIn rats, a gene test confirmed that blood vessel tissue makes its own oxytocin.
Peptide
Oxytocin
Outcome
Not applicableOxytocin synthesis in vascular tissue
Study
ratn: not reported in source
rat vasculature
Outcome group
Endogenous peptide levels · Cardiovascular
Source sentences
Summary
Reverse-transcribed PCR confirmed OT synthesis in these tissues.
1 context sentence(design, population, supporting numbers)
Summary · context
Consequently, we prepared acid extracts of the pulmonary artery and vena cava of female rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1081191703

Studies that did not test the peptide alone4

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

06AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In immature female rats, diethylstilbestrol treatment increased oxytocin receptor mRNA in both the aorta and the vena cava.
In plain wordsIn young female rats, diethylstilbestrol raised oxytocin receptor gene activity in both the main artery and the main vein.
Peptide
Oxytocin
Outcome
IncreaseOxytocin receptor mRNA after diethylstilbestrol
Study
ratn: not reported in source
rat vasculature
Outcome group
Receptor activity and mechanism · Cardiovascular
Measurements
OTR mRNA increase
4-fold
aorta
OTR mRNA increase
2-fold
vena cava
Source sentences
Summary
In addition, we have demonstrated that diethylstilbestrol treatment of immature female rats increased OT significantly in the vena cava but not in the aorta and augmented OTR mRNA in both the aorta (4-fold) and vena cava (2-fold), implying regulation by estrogen.
1 context sentence(design, population, supporting numbers)
Summary · context
Consequently, we prepared acid extracts of the pulmonary artery and vena cava of female rats.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1081191709
07LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In rats, a selective oxytocin receptor ligand detected a high number of oxytocin-binding sites in the vena cava and aorta.
In plain wordsIn rats, tests found many oxytocin-binding sites in the main vein and artery.
Peptide
Oxytocin
Outcome
Not applicableOxytocin-binding sites in vena cava and aorta
Study
ratn: not reported in source
rat vasculature
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
Using the selective OT receptor ligand compound VI, we detected a high number of OT-binding sites in the rat vena cava and aorta.
1 context sentence(design, population, supporting numbers)
Summary · context
Consequently, we prepared acid extracts of the pulmonary artery and vena cava of female rats.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1081191704
08LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In rats, oxytocin receptor mRNA was found in the vena cava, pulmonary vein and pulmonary artery, with lower levels in the aorta.
In plain wordsIn rats, the oxytocin receptor gene was active in several blood vessels, with the lowest levels in the aorta.
Peptide
Oxytocin
Outcome
Not applicableOxytocin receptor mRNA distribution
Study
ratn: not reported in source
rat vasculature
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
Furthermore, OT receptor (OTR) mRNA was found in the vena cava, pulmonary vein, and pulmonary artery with lower levels in the aorta, suggesting vessel-specific OTR distribution.
1 context sentence(design, population, supporting numbers)
Summary · context
Consequently, we prepared acid extracts of the pulmonary artery and vena cava of female rats.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1081191705
09LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In rats, high oxytocin receptor mRNA abundance in the vena cava and pulmonary vein was associated with high atrial natriuretic peptide mRNA.
In plain wordsIn rats, high oxytocin receptor gene activity in veins went together with high atrial natriuretic peptide gene activity.
Peptide
Oxytocin
Outcome
Not applicableOxytocin receptor mRNA and atrial natriuretic peptide mRNA
Study
ratn: not reported in source
rat vasculature
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
The abundance of OTR mRNA in the vena cava and pulmonary vein was associated with high atrial natriuretic peptide mRNA.
1 context sentence(design, population, supporting numbers)
Summary · context
Consequently, we prepared acid extracts of the pulmonary artery and vena cava of female rats.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1081191706

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · source ClinicalTrials.gov (opens in a new tab)

Status unknownPhase 2/3NCT03001635

Role of Oxytocin in Myocardial Infarction

Sheba Medical Centern = 52Jan 2017 to est. Dec 2018 (primary)

Myocardial Infarction

Trial page ClinicalTrials.govUpdated 23 Dec 2016

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

PepBank is a research reference. Talk to a doctor before you use any peptide.