Studies on the gonadotropin-releasing activity of thymulin: changes with age.

Brown OA, Sosa YE, Dardenne M, Pléau JM, Goya RG

The journals of gerontology. Series A, Biological sciences and medical sciences1 Apr 2000Cited by 17 (Europe PMC)

PMID10811143DOI10.1093/gerona/55.4.b170PepBankPUB-10811143

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

4 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueMechanism
In young and senescent rat pituitary cells, thymulin perifusion significantly stimulated LH release.
In plain wordsIn lab tests, thymulin stimulated LH release from young and old rat pituitary cells.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseLH release during perifusion
Study
ratn: not reported in source
dispersed anterior pituitary cells from female rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
10(-6) to 10(-5) MAs given in this study (rat).
Source sentences
Summary
Perifusion of young and senescent AP cells with thymulin doses of 10(-6) to 10(-5) M gave a significant stimulatory response for LH but not FSH.
1 context sentence(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin, a zinc-dependent nonapeptide produced by the thymic epithelial cells, to influence the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from dispersed anterior pituitary (AP) cells from young, adult, and senescent female rats.
Report a problemFND-1081114301
02LabEx vivo tissueMechanism
In young and senescent rat pituitary cells, thymulin perifusion did not significantly stimulate FSH release.
In plain wordsIn lab tests, thymulin did not significantly stimulate FSH release from young and old rat pituitary cells.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeFSH release during perifusion
Study
ratn: not reported in source
dispersed anterior pituitary cells from female rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
10(-6) to 10(-5) MAs given in this study (rat).
Source sentences
Summary
Perifusion of young and senescent AP cells with thymulin doses of 10(-6) to 10(-5) M gave a significant stimulatory response for LH but not FSH.
1 context sentence(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin, a zinc-dependent nonapeptide produced by the thymic epithelial cells, to influence the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from dispersed anterior pituitary (AP) cells from young, adult, and senescent female rats.
Report a problemFND-1081114302
03LabEx vivo tissueMechanism
In rat pituitary cells of both age groups, thymulin stimulated LH release with time and dose dependence, maximally at 10(-7) M.
In plain wordsIn lab tests, thymulin stimulated LH release from rat pituitary cells depending on dose and incubation time.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseLH release during incubation
Study
ratn: not reported in source
dispersed anterior pituitary cells from female rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
10(-8) to 10(-3) MAs given in this study (rat).
Source sentences
Summary
AP cells from both age groups incubated with 10(-8) to 10(-3) M thymulin showed a time- and dose-dependent response for both gonadotropins, with a maximal stimulation at 10(-7) M.
1 context sentence(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin, a zinc-dependent nonapeptide produced by the thymic epithelial cells, to influence the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from dispersed anterior pituitary (AP) cells from young, adult, and senescent female rats.
Report a problemFND-1081114303
04LabEx vivo tissueMechanism
In rat pituitary cells of both age groups, thymulin stimulated FSH release with time and dose dependence, maximally at 10(-7) M.
In plain wordsIn lab tests, thymulin stimulated FSH release from rat pituitary cells depending on dose and incubation time.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseFSH release during incubation
Study
ratn: not reported in source
dispersed anterior pituitary cells from female rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
10(-8) to 10(-3) MAs given in this study (rat).
Source sentences
Summary
AP cells from both age groups incubated with 10(-8) to 10(-3) M thymulin showed a time- and dose-dependent response for both gonadotropins, with a maximal stimulation at 10(-7) M.
1 context sentence(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin, a zinc-dependent nonapeptide produced by the thymic epithelial cells, to influence the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from dispersed anterior pituitary (AP) cells from young, adult, and senescent female rats.
Report a problemFND-1081114304

Studies that did not test the peptide alone7

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

05LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueMechanism
In rat pituitary cells tested with thymulin, gonadotropin release was consistently lower in senescent cells.
In plain wordsIn lab tests with thymulin, old rat pituitary cells released less gonadotropin than younger cells.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseAge-related gonadotropin release
Study
ratn: not reported in source
dispersed anterior pituitary cells from female rats
Comparator
Younger cells
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Gonadotropin release was always lower in the senescent cells.
2 context sentences(design, population, supporting numbers)
Summary · context
Perifusion of young and senescent AP cells with thymulin doses of 10(-6) to 10(-5) M gave a significant stimulatory response for LH but not FSH.
Summary · context
We assessed the ability of thymulin, a zinc-dependent nonapeptide produced by the thymic epithelial cells, to influence the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from dispersed anterior pituitary (AP) cells from young, adult, and senescent female rats.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-1081114305
06LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueMechanism
In rat pituitary cells, antithymulin serum completely blocked thymulin secretagogue activity.
In plain wordsIn lab tests, antithymulin serum completely blocked thymulin activity in rat pituitary cells.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseAntiserum inhibition of secretagogue activity
Study
ratn: not reported in source
dispersed anterior pituitary cells from female rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Preincubation of thymulin with an antithymulin serum completely quenched the secretagogue activity of the hormone.
1 context sentence(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin, a zinc-dependent nonapeptide produced by the thymic epithelial cells, to influence the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from dispersed anterior pituitary (AP) cells from young, adult, and senescent female rats.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-1081114306
07LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueMechanism
In rat pituitary cells, thymulin and GnRH had a synergistic effect on LH release.
In plain wordsIn lab tests, thymulin and GnRH acted synergistically on LH release from rat pituitary cells.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseLH release with GnRH
Study
ratn: not reported in source
dispersed anterior pituitary cells from female rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Coincubation of thymulin with the secretagogue gonadotropin-releasing hormone (GnRH) revealed a synergistic effect on LH release and an additive effect on the release of FSH.
1 context sentence(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin, a zinc-dependent nonapeptide produced by the thymic epithelial cells, to influence the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from dispersed anterior pituitary (AP) cells from young, adult, and senescent female rats.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-1081114307
08LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueMechanism
In rat pituitary cells, thymulin and GnRH had an additive effect on FSH release.
In plain wordsIn lab tests, thymulin and GnRH had an additive effect on FSH release from rat pituitary cells.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseFSH release with GnRH
Study
ratn: not reported in source
dispersed anterior pituitary cells from female rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Coincubation of thymulin with the secretagogue gonadotropin-releasing hormone (GnRH) revealed a synergistic effect on LH release and an additive effect on the release of FSH.
1 context sentence(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin, a zinc-dependent nonapeptide produced by the thymic epithelial cells, to influence the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from dispersed anterior pituitary (AP) cells from young, adult, and senescent female rats.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-1081114308
09LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueMechanism
In rat pituitary cells, EGTA blocked thymulin-induced gonadotropin release.
In plain wordsIn lab tests, EGTA blocked thymulin-induced hormone release from rat pituitary cells.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseEGTA inhibition of gonadotropin release
Study
ratn: not reported in source
dispersed anterior pituitary cells from female rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
The calcium chelator EGTA blocked the gonadotropin-releasing activity of thymulin in AP cells.
1 context sentence(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin, a zinc-dependent nonapeptide produced by the thymic epithelial cells, to influence the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from dispersed anterior pituitary (AP) cells from young, adult, and senescent female rats.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-1081114309
10LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueMechanism
In rat pituitary cells, caffeine, NaF, and forskolin increased thymulin-stimulated gonadotropin release.
In plain wordsIn lab tests, cAMP enhancers increased thymulin-stimulated hormone release from rat pituitary cells.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseGonadotropin release with cAMP enhancers
Study
ratn: not reported in source
dispersed anterior pituitary cells from female rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
The cAMP enhancers, caffeine, NaF, and forskolin significantly increased the thymulin-stimulated release of gonadotropins.
1 context sentence(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin, a zinc-dependent nonapeptide produced by the thymic epithelial cells, to influence the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from dispersed anterior pituitary (AP) cells from young, adult, and senescent female rats.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-1081114310
11LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueMechanism
In rat pituitary cells, LiCl potentiated thymulin effects on gonadotropins.
In plain wordsIn lab tests, LiCl increased thymulin effects on hormone release from rat pituitary cells.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseGonadotropin release with LiCl
Study
ratn: not reported in source
dispersed anterior pituitary cells from female rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
The inositol phosphate enhancer LiCl potentiated the action of thymulin on gonadotropins.
1 context sentence(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin, a zinc-dependent nonapeptide produced by the thymic epithelial cells, to influence the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from dispersed anterior pituitary (AP) cells from young, adult, and senescent female rats.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-1081114311

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 2
21 Oct 2026, 13:55 UTC
Study data updated · source update from Europe PMC
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

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Studies on the gonadotropin-releasing activity of thymulin: changes with age.

Summary

Results from this study11

Studies that did not test the peptide alone7

Version history

Subjects

Publication types

MeSH terms