Skip to content

Study · Animal study (in vivo) · rat · 2000

9 results

Gonadotropin-releasing hormone analogs stimulate and testosterone inhibits the recovery of spermatogenesis in irradiated rats.

Shetty G, Wilson G, Huhtaniemi I, Shuttlesworth GA, Reissmann T, Meistrich ML

Endocrinology1 May 2000Cited by 66 (Europe PMC)

PMID10803584 (opens in a new tab)DOI10.1210/endo.141.5.7446 (opens in a new tab)PepBankPUB-10803584
Source linkPubMedAsk about this study
Jump to 9 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated rats, leuprolide reduced intratesticular testosterone to 4% of irradiated-control levels.

    In plain wordsIn rats, leuprolide reduced intratesticular testosterone to 4% of irradiated-control levels.

    Peptide
    Leuprolide
    Outcome
    DecreaseIntratesticular testosterone
    Study

    ratn: not reported in source

    Irradiated rats
    Comparator
    Irradiated-only rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 10 weeksAs given in this study (rat).

    Measurements

    Intratesticular testosterone
    4 % of irradiated control
    reported result

    Source sentences

    Summary
    Treatment with a GnRH agonist (Lupron) for 10 weeks after irradiation reduced the intratesticular T concentration (ITT) to 4% of that in irradiated rats and serum FSH to undetectable levels without altering serum LH levels.
    1 context sentence
    Summary · context
    We investigated the effects of GnRH analogs, different doses of testosterone (T), an androgen receptor antagonist (flutamide), and combinations of these on the recovery of spermatogenesis after irradiation.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated rats, leuprolide reduced serum FSH to undetectable levels.

    In plain wordsIn rats, leuprolide reduced serum FSH to undetectable levels compared with irradiated controls.

    Peptide
    Leuprolide
    Outcome
    DecreaseSerum FSH
    Study

    ratn: not reported in source

    Irradiated rats
    Comparator
    Irradiated-only rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 10 weeksAs given in this study (rat).

    Source sentences

    Summary
    Treatment with a GnRH agonist (Lupron) for 10 weeks after irradiation reduced the intratesticular T concentration (ITT) to 4% of that in irradiated rats and serum FSH to undetectable levels without altering serum LH levels.
    1 context sentence
    Summary · context
    We investigated the effects of GnRH analogs, different doses of testosterone (T), an androgen receptor antagonist (flutamide), and combinations of these on the recovery of spermatogenesis after irradiation.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated rats, leuprolide did not alter serum LH levels.

    In plain wordsIn rats, leuprolide did not alter serum LH levels compared with irradiated controls.

    Peptide
    Leuprolide
    Outcome
    No significant changeSerum LH
    Study

    ratn: not reported in source

    Irradiated rats
    Comparator
    Irradiated-only rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 10 weeksAs given in this study (rat).

    Source sentences

    Summary
    Treatment with a GnRH agonist (Lupron) for 10 weeks after irradiation reduced the intratesticular T concentration (ITT) to 4% of that in irradiated rats and serum FSH to undetectable levels without altering serum LH levels.
    1 context sentence
    Summary · context
    We investigated the effects of GnRH analogs, different doses of testosterone (T), an androgen receptor antagonist (flutamide), and combinations of these on the recovery of spermatogenesis after irradiation.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated rats, cetrorelix suppressed LH to <7% of irradiated-only levels within 2 weeks, maintaining suppression approximately 3 to 4 weeks.

    In plain wordsIn rats, cetrorelix suppressed LH to <7% of irradiated-only levels within 2 weeks.

    Peptide
    Cetrorelix
    Outcome
    DecreaseSerum LH
    Study

    ratn: not reported in source

    Irradiated rats
    Comparator
    Irradiated-only rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · injectionAs given in this study (rat).

    Measurements

    LH
    < 7 % of irradiated-only levels
    within 2 weeks

    Source sentences

    Summary
    Injection of a GnRH antagonist (Cetrorelix) at 3 weeks after irradiation suppressed LH, FSH, and ITT to <7%, 32%, and 10%, respectively, of levels in irradiated-only rats within 2 weeks; suppression was maintained for approximately 3 to 4 weeks.
    1 context sentence
    Summary · context
    We investigated the effects of GnRH analogs, different doses of testosterone (T), an androgen receptor antagonist (flutamide), and combinations of these on the recovery of spermatogenesis after irradiation.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated rats, cetrorelix suppressed FSH to 32% of irradiated-only levels within 2 weeks, maintaining suppression approximately 3 to 4 weeks.

    In plain wordsIn rats, cetrorelix suppressed FSH to 32% of irradiated-only levels within 2 weeks.

    Peptide
    Cetrorelix
    Outcome
    DecreaseSerum FSH
    Study

    ratn: not reported in source

    Irradiated rats
    Comparator
    Irradiated-only rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · injectionAs given in this study (rat).

    Measurements

    FSH
    32 % of irradiated-only levels
    within 2 weeks

    Source sentences

    Summary
    Injection of a GnRH antagonist (Cetrorelix) at 3 weeks after irradiation suppressed LH, FSH, and ITT to <7%, 32%, and 10%, respectively, of levels in irradiated-only rats within 2 weeks; suppression was maintained for approximately 3 to 4 weeks.
    1 context sentence
    Summary · context
    We investigated the effects of GnRH analogs, different doses of testosterone (T), an androgen receptor antagonist (flutamide), and combinations of these on the recovery of spermatogenesis after irradiation.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated rats, cetrorelix suppressed intratesticular testosterone to 10% of irradiated-only levels within 2 weeks, maintaining suppression approximately 3 to 4 weeks.

    In plain wordsIn rats, cetrorelix suppressed intratesticular testosterone to 10% of irradiated-only levels within 2 weeks.

    Peptide
    Cetrorelix
    Outcome
    DecreaseIntratesticular testosterone
    Study

    ratn: not reported in source

    Irradiated rats
    Comparator
    Irradiated-only rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · injectionAs given in this study (rat).

    Measurements

    Intratesticular testosterone
    10 % of irradiated-only levels
    within 2 weeks

    Source sentences

    Summary
    Injection of a GnRH antagonist (Cetrorelix) at 3 weeks after irradiation suppressed LH, FSH, and ITT to <7%, 32%, and 10%, respectively, of levels in irradiated-only rats within 2 weeks; suppression was maintained for approximately 3 to 4 weeks.
    1 context sentence
    Summary · context
    We investigated the effects of GnRH analogs, different doses of testosterone (T), an androgen receptor antagonist (flutamide), and combinations of these on the recovery of spermatogenesis after irradiation.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated rats, leuprolide induced spermatogenic recovery, with a repopulation index of 58% at week 10.

    In plain wordsIn rats, leuprolide induced spermatogenic recovery versus irradiated controls, with a repopulation index of 58% at week 10.

    Peptide
    Leuprolide
    Outcome
    IncreaseSpermatogenic recovery at week 10
    Study

    ratn: not reported in source

    Irradiated rats
    Comparator
    Irradiated-only rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    Repopulation index
    58%
    leuprolide at week 10
    Repopulation index
    < 0.6%
    irradiated controls at weeks 10 to 20

    Source sentences

    Summary
    Spermatogenic recovery was induced by both the GnRH agonist (RI = 58% at week 10; 91% at week 20) and antagonist (RI = 70% at week 13).
    3 context sentences
    Summary · context
    Treatment with a GnRH agonist (Lupron) for 10 weeks after irradiation reduced the intratesticular T concentration (ITT) to 4% of that in irradiated rats and serum FSH to undetectable levels without altering serum LH levels.
    Summary · context
    The percentage of tubules with differentiated germ cells (repopulation index, RI) was <0.6% at weeks 10 to 20 after irradiation.
    Summary · context
    We investigated the effects of GnRH analogs, different doses of testosterone (T), an androgen receptor antagonist (flutamide), and combinations of these on the recovery of spermatogenesis after irradiation.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated rats, leuprolide induced spermatogenic recovery, with a repopulation index of 91% at week 20.

    In plain wordsIn rats, leuprolide induced spermatogenic recovery versus irradiated controls, with a repopulation index of 91% at week 20.

    Peptide
    Leuprolide
    Outcome
    IncreaseSpermatogenic recovery at week 20
    Study

    ratn: not reported in source

    Irradiated rats
    Comparator
    Irradiated-only rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    Repopulation index
    91%
    leuprolide at week 20
    Repopulation index
    < 0.6%
    irradiated controls at weeks 10 to 20

    Source sentences

    Summary
    Spermatogenic recovery was induced by both the GnRH agonist (RI = 58% at week 10; 91% at week 20) and antagonist (RI = 70% at week 13).
    3 context sentences
    Summary · context
    Treatment with a GnRH agonist (Lupron) for 10 weeks after irradiation reduced the intratesticular T concentration (ITT) to 4% of that in irradiated rats and serum FSH to undetectable levels without altering serum LH levels.
    Summary · context
    The percentage of tubules with differentiated germ cells (repopulation index, RI) was <0.6% at weeks 10 to 20 after irradiation.
    Summary · context
    We investigated the effects of GnRH analogs, different doses of testosterone (T), an androgen receptor antagonist (flutamide), and combinations of these on the recovery of spermatogenesis after irradiation.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated rats, cetrorelix induced spermatogenic recovery, with a repopulation index of 70% at week 13.

    In plain wordsIn rats, cetrorelix induced spermatogenic recovery versus irradiated controls, with a repopulation index of 70% at week 13.

    Peptide
    Cetrorelix
    Outcome
    IncreaseSpermatogenic recovery at week 13
    Study

    ratn: not reported in source

    Irradiated rats
    Comparator
    Irradiated-only rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    Repopulation index
    70%
    cetrorelix at week 13
    Repopulation index
    < 0.6%
    irradiated controls at weeks 10 to 20

    Source sentences

    Summary
    Spermatogenic recovery was induced by both the GnRH agonist (RI = 58% at week 10; 91% at week 20) and antagonist (RI = 70% at week 13).
    3 context sentences
    Summary · context
    Injection of a GnRH antagonist (Cetrorelix) at 3 weeks after irradiation suppressed LH, FSH, and ITT to <7%, 32%, and 10%, respectively, of levels in irradiated-only rats within 2 weeks; suppression was maintained for approximately 3 to 4 weeks.
    Summary · context
    The percentage of tubules with differentiated germ cells (repopulation index, RI) was <0.6% at weeks 10 to 20 after irradiation.
    Summary · context
    We investigated the effects of GnRH analogs, different doses of testosterone (T), an androgen receptor antagonist (flutamide), and combinations of these on the recovery of spermatogenesis after irradiation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 2

    27 Oct 2026, 16:37 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.