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Study · Not a test of the peptide alone · 2000

1 result

Effect of nicorandil upon different guinea-pig and rat isolated organ preparations in vitro.

Barcenilla A, Alamo C, Carvajal A, García-Pozo J, Velasco A

Arzneimittel-Forschung1 Apr 2000Cited by 1 (Europe PMC)

PMID10800632 (opens in a new tab)DOI10.1055/s-0031-1300212 (opens in a new tab)PepBankPUB-10800632
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In isolated rat uterus, nicorandil acted as a non-competitive antagonist of the response to oxytocin, serotonin and histamine.

    In plain wordsIn lab tests on rat uterus tissue, nicorandil reduced the response to oxytocin and other agents.

    Peptide
    Oxytocin
    Outcome
    DecreaseNicorandil effect on isolated rat uterus response to oxytocin
    Study

    ratn: not reported in source

    isolated uterus preparation
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    The drug exerts a non-competitive antagonist effect upon rat isolated uterus response to serotonin, histamine, oxytocin, and, at high concentrations, inhibits guinea-pig isolated ileum responses to acetylcholine, histamine, 4-aminopyridine and potassium.
    1 context sentence
    Summary · context
    A study of the effect of nicorandil (N-2-(hydroxyethyl)nicotinamide nitrate, CAS 65141-46-0), a potassium channel and guanylatecyclase activator, upon preparations of rat was deferens and uterus, and guinea pig ileum was performed.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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