The effects of growth hormone-releasing peptide-2 (GHRP-2) on the release of growth hormone and growth performance in swine.

Phung LT, Inoue H, Nou V, Lee HG, Vega RA, Matsunaga N, Hidaka S, Kuwayama H, Hidari H

Domestic animal endocrinology1 Apr 2000Cited by 6 (Europe PMC)

PMID10793268DOI10.1016/s0739-7240(00)00050-3PepBankPUB-10793268

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In castrated male swine, single intravenous GHRP‑2 injections stimulated GH release in a dose-dependent manner.
In plain wordsIn pigs, single GHRP‑2 injections into a vein raised GH release, and higher doses gave a larger rise.
Peptide
GHRP-2
Outcome
IncreaseGH release after single i.v. GHRP-2
Study
pign: not reported in source
cross-bred castrated male swine
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2, 10, 30 and 100 microg/kg BW · intravenousAs given in this study (pig).
Source sentences
Summary
The single intravenous (i. v.) injection of GHRP-2 at doses of 2, 10, 30 and 100 microg/kg body weight (BW) to cross-bred castrated male swine stimulated GH release in a dose-dependent manner, with a return to the baseline by 120 min.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of GHRP-2 (also named KP102), a new growth hormone-releasing peptide, on the release of growth hormone (GH) and growth performance were examined in swine.
Report a problemFND-1079326801
02AnimalAnimal study (in vivo)Efficacy outcome
In swine, peak GH concentrations after single intravenous GHRP‑2 injections were higher than after saline.
In plain wordsIn pigs, the peak GH level after GHRP‑2 was higher than after saline.
Peptide
GHRP-2
Outcome
IncreasePeak GH concentration after single i.v. GHRP-2
Study
pign: not reported in source
cross-bred castrated male swine
Comparator
Saline
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2, 10, 30 and 100 microg/kg BW · intravenousAs given in this study (pig).
Source sentences
Summary
The peak GH concentrations and GH areas under the response curves (GH AUCs) for 180 min after the injections of GHRP-2 were higher (P < 0.05) than those after the injection of saline.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of GHRP-2 (also named KP102), a new growth hormone-releasing peptide, on the release of growth hormone (GH) and growth performance were examined in swine.
Report a problemFND-1079326802
03AnimalAnimal study (in vivo)Efficacy outcome
In swine, GH areas under the response curve for 180 min after single intravenous GHRP‑2 injections were higher than after saline.
In plain wordsIn pigs, the total GH released over 180 minutes after GHRP‑2 was higher than after saline.
Peptide
GHRP-2
Outcome
IncreaseGH AUC after single i.v. GHRP-2
Study
pign: not reported in source
cross-bred castrated male swine
Comparator
Saline
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2, 10, 30 and 100 microg/kg BW · intravenousAs given in this study (pig).
Source sentences
Summary
The peak GH concentrations and GH areas under the response curves (GH AUCs) for 180 min after the injections of GHRP-2 were higher (P < 0.05) than those after the injection of saline.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of GHRP-2 (also named KP102), a new growth hormone-releasing peptide, on the release of growth hormone (GH) and growth performance were examined in swine.
Report a problemFND-1079326803
04AnimalAnimal study (in vivo)Efficacy outcome
In swine, the GH responses to repeated intravenous GHRP‑2 injections decreased after each injection.
In plain wordsIn pigs, the GH response became smaller after each repeated GHRP‑2 injection.
Peptide
GHRP-2
Outcome
DecreaseGH response to repeated i.v. GHRP-2
Study
pign: not reported in source
cross-bred castrated male swine
Comparator
Previous injection
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
30 microg/kg BW at 2-h intervals for 6 h · intravenousAs given in this study (pig).
Source sentences
Summary
The GH responses to repeated i.v. injections of GHRP-2 (30 microg/kg BW) at 2-h intervals for 6 h were decreased after each injection.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of GHRP-2 (also named KP102), a new growth hormone-releasing peptide, on the release of growth hormone (GH) and growth performance were examined in swine.
Report a problemFND-1079326804
05AnimalAnimal study (in vivo)Efficacy outcome
In swine, GH areas under the response curve on days 1, 10 and 30 of GHRP‑2 treatment were higher than in saline-treated swine.
In plain wordsIn pigs, daily GHRP‑2 for 30 days kept GH release higher than saline on days 1, 10 and 30.
Peptide
GHRP-2
Outcome
IncreaseGH AUC during 30 days of s.c. GHRP-2
Study
pign: not reported in source
cross-bred castrated male swine
Comparator
Saline
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
30 microg/kg BW once daily · subcutaneous · 30 daysAs given in this study (pig).
Source sentences
Summary
The GH AUCs for 300 min after the injections on d 1, 10 and 30 of treatment in GHRP-2-treated swine were higher than those in saline-treated swine.
2 context sentences(design, population, supporting numbers)
Summary · context
The chronic subcutaneous (s.c.) administration of GHRP-2 (30 microg/kg BW) once daily for 30 days consistently stimulated GH release.
Summary · context
The effects of GHRP-2 (also named KP102), a new growth hormone-releasing peptide, on the release of growth hormone (GH) and growth performance were examined in swine.
Report a problemFND-1079326805
06AnimalAnimal study (in vivo)Efficacy outcome
In swine, chronic GHRP‑2 administration caused a partial attenuation of the GH response between day 1 and day 10 of treatment.
In plain wordsIn pigs, the GH response to daily GHRP‑2 became partly weaker between day 1 and day 10.
Peptide
GHRP-2
Outcome
DecreaseAttenuation of GH response during chronic GHRP-2
Study
pign: not reported in source
cross-bred castrated male swine
Comparator
Day 1
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
30 microg/kg BW once daily · subcutaneous · 30 daysAs given in this study (pig).
Source sentences
Summary
However, chronic administration of GHRP-2 caused a partial attenuation of GH response between d 1 and 10 of treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of GHRP-2 (also named KP102), a new growth hormone-releasing peptide, on the release of growth hormone (GH) and growth performance were examined in swine.
Report a problemFND-1079326806
07AnimalAnimal study (in vivo)Efficacy outcome
In swine, chronic subcutaneous GHRP‑2 increased average daily gain by 22.35% over saline control values.
In plain wordsIn pigs, 30 days of GHRP‑2 raised daily weight gain by 22.35% compared with saline.
Peptide
GHRP-2
Outcome
IncreaseAverage daily gain with chronic GHRP-2
Study
pign: not reported in source
cross-bred castrated male swine
Comparator
Saline
Outcome group
Body weight · Metabolic and weight
Studied dose
30 microg/kg BW once daily · subcutaneous · 30 daysAs given in this study (pig).
Measurements
average daily gain increase
22.35%
versus saline
Source sentences
Summary
The chronic s.c. administration of GHRP-2 also increased average daily gain for the entire treatment period by 22.35% (P < 0.05) and feed efficiency (feed/gain) by 20.64% (P < 0.01) over the saline control values, but did not significantly affect daily feed intake.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of GHRP-2 (also named KP102), a new growth hormone-releasing peptide, on the release of growth hormone (GH) and growth performance were examined in swine.
Report a problemFND-1079326807
08AnimalAnimal study (in vivo)Efficacy outcome
In swine, chronic subcutaneous GHRP‑2 increased feed efficiency (feed/gain) by 20.64% over saline control values.
In plain wordsIn pigs, 30 days of GHRP‑2 changed feed efficiency by 20.64% compared with saline.
Peptide
GHRP-2
Outcome
IncreaseFeed efficiency (feed/gain) with chronic GHRP-2
Study
pign: not reported in source
cross-bred castrated male swine
Comparator
Saline
Outcome group
Body weight · Metabolic and weight
Studied dose
30 microg/kg BW once daily · subcutaneous · 30 daysAs given in this study (pig).
Measurements
feed efficiency (feed/gain) increase
20.64%
versus saline
Source sentences
Summary
The chronic s.c. administration of GHRP-2 also increased average daily gain for the entire treatment period by 22.35% (P < 0.05) and feed efficiency (feed/gain) by 20.64% (P < 0.01) over the saline control values, but did not significantly affect daily feed intake.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of GHRP-2 (also named KP102), a new growth hormone-releasing peptide, on the release of growth hormone (GH) and growth performance were examined in swine.
Report a problemFND-1079326808
09AnimalAnimal study (in vivo)Efficacy outcome
In swine, chronic subcutaneous GHRP‑2 did not significantly affect daily feed intake.
In plain wordsIn pigs, 30 days of GHRP‑2 did not significantly change how much they ate each day.
Peptide
GHRP-2
Outcome
No significant changeDaily feed intake with chronic GHRP-2
Study
pign: not reported in source
cross-bred castrated male swine
Comparator
Saline
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
30 microg/kg BW once daily · subcutaneous · 30 daysAs given in this study (pig).
Source sentences
Summary
The chronic s.c. administration of GHRP-2 also increased average daily gain for the entire treatment period by 22.35% (P < 0.05) and feed efficiency (feed/gain) by 20.64% (P < 0.01) over the saline control values, but did not significantly affect daily feed intake.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of GHRP-2 (also named KP102), a new growth hormone-releasing peptide, on the release of growth hormone (GH) and growth performance were examined in swine.
Report a problemFND-1079326809

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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