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Study · Animal study (in vivo) · rat · 1999

2 results

Memory restoring and neuroprotective effects of the proline-containing dipeptide, GVS-111, in a photochemical stroke model.

Ostrovskaya RU, Romanova GA, Barskov IV, Shanina EV, Gudasheva TA, Victorov IV, Voronina TA, Seredenin SB

Behavioural pharmacology1 Sept 1999Cited by 23 (Europe PMC)

PMID10780261 (opens in a new tab)DOI10.1097/00008877-199909000-00013 (opens in a new tab)PepBankPUB-10780261
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with photochemical stroke, GVS-111 attenuated the passive avoidance deficit.

    In plain wordsIn rats with stroke, GVS-111 reduced the memory deficit.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreasePassive avoidance deficit
    Study

    ratn: not reported in source

    Photochemical frontal cortex stroke
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.5 mg/kg/day · intravenous · First dose 1 h after lesion, then 9 post-operative daysAs given in this study (rat).

    Source sentences

    Summary
    N-Phenylacetyl-L-prolylglycine ethyl ester (GVS-111) administered intravenously at a dose of 0.5 mg/kg/day, for the first time 1 h after ischaemic lesion and then for 9 post-operative days, with the last administration 15 min before testing, attenuated the deficit.
    1 context sentence
    Summary · context
    Local thrombosis of the frontal cortex (Fr1 and Fr3 fields), caused by combination of the intravenous photosensitive dye Rose Bengal administration with focused high-intensity illumination of the frontal bone, was shown to provoke a pronounced deficit in step-through passive avoidance performance in rats
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with photochemical stroke, GVS-111 significantly diminished infarct volume.

    In plain wordsIn rats with stroke, GVS-111 reduced the volume of damaged brain tissue.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseInfarct volume
    Study

    ratn: not reported in source

    Photochemical frontal cortex stroke
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0.5 mg/kg/day · intravenous · First dose 1 h after lesion, then 9 post-operative daysAs given in this study (rat).

    Source sentences

    Summary
    This treatment significantly diminished the volume of the infarcted area.
    1 context sentence
    Summary · context
    N-Phenylacetyl-L-prolylglycine ethyl ester (GVS-111) administered intravenously at a dose of 0.5 mg/kg/day, for the first time 1 h after ischaemic lesion and then for 9 post-operative days, with the last administration 15 min before testing, attenuated the deficit.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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